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Pharmacological properties

a preparation of natural origin, obtained according to the original technology from the aerial part of the plant tribulus terrestris l. the preparation contains predominantly steroidal saponins of the furostanol type, among which protodioscin predominates. the mechanism of action of the drug is due to this component.

Protodioscin is metabolized in the body to dehydroepiandrosterone (DHEA), which has a beneficial effect on cell membrane permeability, erectile function, cholesterol metabolism and immunity. Other active furostanol saponins, which are part of the extract of the plant Tribulus terrestris L., probably modulate the effect of protodioscin.

Tribestan has a general tonic effect and stimulates some functions of the reproductive system. In men, it restores and improves libido and erection. It has a stimulating effect on spermatogenesis, increasing the number of sperm and their motility, increases testosterone levels. In women, Tribestan also improves libido, stimulates ovulation. Favorably affects vasomotor manifestations with natural and post-castration climacteric syndrome as a result of its balancing effect on hormonal activity.

Results from healthy volunteers show that Tribestan affects the level of hormones in the pituitary-gonadal axis in blood plasma without significantly changing the levels of adrenal hormones and ACTH.

Tribestan has a lipid-lowering effect, and in patients with dyslipoproteinemia significantly reduces total cholesterol and LDL, without affecting the levels of TG and HDL in plasma.

Tribestan has antihypertensive and diuretic effects.

Pharmacokinetics The active substance protodioscin is rapidly excreted from blood plasma - already within the 3rd hour its concentration is negligible. Excreted mainly with bile. The low percentage of excretion of unchanged protodioscin compared with the dose taken confirms the assumption that it is intensely biotransformed in the body.


For the prevention and treatment (monotherapy and complex) of the reproductive system disorders in men and women. with erectile dysfunction for men - to enhance libido, strength and duration of an erection. as monotherapy or in the complex treatment of certain forms of infertility in men: infertility based on idiopathic oligoastenoteratospermia (decrease in the quantity and quality of sperm in the excreted sperm); infertility in the absence of improved sperm indices within 1 year after surgery for varicocele; immunologically determined infertility.

Women with menopause and postcastration syndrome with identified neurovegetative and neuropsychic manifestations; with endocrine ovarian infertility. In case of impaired fat metabolism (dyslipoproteinemia) to reduce total cholesterol and LDL.


The tablets are taken orally after meals.

With a decrease in libido, impotence and infertility. In men with reduced libido, impotence and infertility, a dosage of 1-2 tablets 3 times a day is recommended. The duration of treatment is at least 90 days. The course of treatment can be repeated until a positive therapeutic effect is obtained.

In women with endocrine infertility, a dosage of 1-2 tablets 3 times a day from the 1st to the 12th day of the menstrual cycle is recommended. This course can be repeated periodically until pregnancy.

Dyslipoproteinemia. 2 tablets 3 times a day. The duration of treatment is at least 3 months.

Menopause and postcastration syndrome in women. 1-2 tablets 3 times a day for 60–90 days. After improvement, they gradually switch to a maintenance dose - 2 tablets per day for 1–2 years.


Tribestan is contraindicated in:

  • hypersensitivity to the components of the drug;
  • severe cardiovascular and renal diseases;
  • prostate adenoma.

Side effects

Hypersensitivity reactions are possible. when taken before meals, the drug may be irritating to the gastric mucosa.

special instructions

In the treatment of women with menopausal syndrome, the transition from a therapeutic to a maintenance dose should be gradual. after a sharp decrease or cancellation of the effective dose of the drug, a reappearance of a complex of climacteric symptoms is possible.

During pregnancy and breastfeeding. The potential risk to humans is unknown. In the absence of clinical studies in pregnant women, the drug Tribestan during pregnancy and lactation is contraindicated. When pregnancy is established, the drug should be discontinued.

Children. It is not recommended to use the drug in children under the age of 18 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect.


The simultaneous use of the drug tribestan with drugs that stimulate ovulation leads to a mutual enhancement of their effects.

The combined use of Tribestan with diuretics can enhance the effects of the latter and potentiate the hypotensive effect of antihypertensive drugs.


To date, there have been no cases of overdose of the drug tribestan. when taking a large amount of the drug, symptomatic treatment is indicated.

Storage conditions

In the original packaging for protection against moisture at a temperature not exceeding 25 ° C.

Tags: Tribestan