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Pharmacological properties

pessaries betadine is an antiseptic drug with a wide spectrum of antimicrobial activity against bacteria, some viruses, fungi and protozoa. Upon contact with the skin and mucous membranes, iodine is gradually released and has a bactericidal effect.

Pharmacokinetics The active substance of the drug is almost not absorbed into the systemic circulation.


Acute and chronic vaginal infections (colpitis):

  • mixed infections;
  • non-specific infections (bacterial vaginosis caused by Cardnerella vaginalis);
  • fungal infections (Candida albicans);
  • vaginal infections as a result of treatment with antibiotics and steroid drugs;
  • trichomoniasis (if necessary, combined systemic treatment should be carried out).

Preoperative prophylaxis during surgical operations in the vagina or during diagnostic procedures.


Betadine, pessaries, removed from the shell and after moisturizing with water, enter deep into the vagina in the supine position. since it is not always possible to avoid leakage of the pessary, it is recommended to wear sanitary pads (do not use tampons).

Dosage 1 vaginal pessary enter deep into the vagina in the evening before bedtime. The drug should be used daily (including during menstruation).

In case of insufficient effectiveness, the course of treatment can be extended as prescribed by the doctor, and the dose can be increased to 2 vaginal pessaries daily.

The duration of use depends on the results of therapy and is determined individually by the doctor. The course of treatment is usually 7 days.

Children. The drug is not intended for use in children.


Hypersensitivity to iodine or other components of the drug; herpetiform dermatitis of dühring; thyroid dysfunction (nodular colloid goiter, endemic goiter and hashimoto thyroiditis); hyperthyroidism; the period before and after treatment and scintigraphy with radioactive iodine in patients with thyroid carcinoma; renal failure.

Side effects

Povidone iodine is usually well tolerated. local reactions are possible, although this substance is considered less irritating.

On the part of the skin and subcutaneous tissue: local skin hypersensitivity reactions, such as contact dermatitis with the appearance of psoriasis-like red small bullous formations. Allergic reactions, including itching, redness, rash, angioedema.

From the kidneys and urinary system: impaired renal function, acute renal failure.

From the endocrine system: hyperthyroidism.

Prolonged use of povidone iodine can lead to the absorption of a large amount of iodine. In some cases, iodine-induced hyperthyroidism has been described, which has arisen as a result of prolonged use of the drug mainly in patients with existing thyroid disease.

On the part of other organs and systems, side effects were only occasionally recorded.

The drug may have a spermicidal effect, and should not be used when fertilization is desired.

In some cases, generalized acute reactions with a decrease in blood pressure and / or shortness of breath (anaphylactic reactions) are possible.

In case of any symptoms should immediately stop using the drug and be sure to consult a doctor.

special instructions

Use in general or prolonged use of povidone iodine should be avoided with:

- treatment with lithium preparations;

- liver and renal failure;

- diseases of the thyroid gland.

The use of povidone iodine can reduce the absorption of iodine by the thyroid gland, which may affect the results of some studies (thyroid scintigraphy, determination of protein-bound iodine, diagnostic procedures using radioactive iodine).When planning these procedures in the application of povidone-iodine, it is necessary to take a break of at least 1–4 weeks.

The oxidizing effect of povidone iodine can cause corrosion of metals, while plastic and synthetic materials are usually insensitive to povidone iodine. In some cases, a color change is possible, which is usually restored.

Povidone iodine is easily removed from textiles and other materials with warm water and soap. Stains that are difficult to remove should be treated with ammonia or sodium thiosulfate.

Excessive use of iodine can cause hyperthyroidism in patients with thyroid disease. The use of Betadine, a pessary, in such patients should last a minimum time. Thyroid function tests should be performed if symptoms of hyperthyroidism appear after treatment.

Betadine, pessaries, are for vaginal use only.

The brown-red color of the pessaries is an indicator of the effectiveness of the drug. Loss of color indicates a significant decrease in the effectiveness of the drug.

The oxidizing effect of povidone-iodine can lead to false-positive diagnostic tests (for example, toluidine and guaiac tests for hemoglobin and glucose in feces and urine).

Use during pregnancy or lactation. Povidone iodine does not have a teratogenic effect. The drug is contraindicated to use after the 2nd month of pregnancy and during lactation. Iodine crosses the placental barrier and can pass into breast milk. During the treatment period, it is necessary to stop breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Povidone-iodine in therapeutic doses does not affect the reaction rate when driving vehicles and working with other mechanisms.


The simultaneous use of povidone iodine and hydrogen peroxide, as well as enzyme preparations containing silver and tauloridine, or antiseptic drugs leads to a mutual decrease in effectiveness. povidone iodine should not be used with mercury preparations due to the risk of alkaline mercury iodide formation.

The drug can react with proteins and unsaturated organic complexes, so the effect of povidone iodine can be compensated by increasing its dose. Avoid prolonged use of the drug in patients receiving lithium preparations.

Due to its oxidizing properties, povidone iodine can affect the results of certain diagnostic tests, such as detecting occult blood in feces or urine, or glucose in urine.

During the use of povidone iodine, thyroid absorption of iodine may decrease, which may affect the results of some diagnostic tests (for example, thyroid scintigraphy, determination of protein-bound iodine, measurements using radioactive iodine) or may interfere with iodine, which is used to thyroid therapy.

Thyroid scintigraphy should be performed after discontinuation of long-term therapy for 1–2 weeks in order to obtain reliable results.


The following symptoms are characteristic of acute iodine intoxication: metallic taste in the mouth, increased salivation, heartburn, pain in the mouth or throat; eye irritation and swelling; skin reactions; gastrointestinal disturbances; impaired renal function, anuria; circulatory failure; laryngeal edema with secondary asphyxia, pulmonary edema, metabolic acidosis, hypernatremia, metabolic disorders.

Treatment: carry out maintenance and symptomatic therapy with control of electrolyte balance, renal and thyroid function.

Storage conditions

At a temperature not exceeding 25 ° c.

Tags: Povidone iodine