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Femiclin tablets vaginal 10 mg

Instruction manual

For medical use of the drug


Active substance: dequalinium chloride;

1 vaginal tablet contains 10 mg of dequalinium chloride;

excipients: lactose, monohydrate; microcrystalline cellulose; magnesium stearate.

Dosage form.

Vaginal tablets.

Basic physical and chemical properties: oblong-shaped tablets, with a biconvex surface, white or almost white.

Pharmacotherapeutic group.

Antimicrobial and antiseptic agents used in gynecology, with the exception of combinations with corticosteroids. quinoline derivatives. Dequalin.

ATX code G01A C05.

Pharmacological properties.


Femiclin contains dequalinium chloride, a quaternary ammonium compound with a wide spectrum of antimicrobial activity against various gram-positive and gram-negative bacteria, fungi, and protozoa unicellular organisms (Trichomonas vaginalis). The activity of dequalinium chloride in vitro was established against the microorganisms that are significant for the vaginal site. This activity is expressed as the minimum inhibitory concentration (MIC).

  MIC (mg / L)   MIC (mg / L)
Gram-positive bacteria Gram-negative bacteria
Streptococci group B 2 – 8 Fusobacteria 32 – 64
Staphylococcus aureus 0,2 – 10 Gardnerella vaginalis 2,0 – 256
Streptococci Group A 0,25 – 20 E. coli 1 – 400
Listeria sp. 4 – 32 Serratia sp. 3,1 – 400
Peptostreptococci 1 – 32 Klebsiella sp. 3,1 – 400
Streptococci group D 0,2 – 64 Pseudomonas sp. 5 – 400
Mushrooms Bacteroides sp./Prevotella sp. 64 – 512
Candida tropicalis 0,2 – 50 Proteus sp. 20 — 1024
Candida albicans 0,2 – 200 The simplest unicellular organisms
Candida glabrata 0,2 – 256 Trichomonas vaginalis 28,8 – 400
Candy krusei 128

After dissolving a vaginal tablet, Femiclin (10 mg of dequalinium chloride) in approximately 2.5–5 ml of vaginal fluid, the concentration of dequalinium chloride in it is 4000–2000 mg / l, which is higher than MIC90 for all pathogenic microorganisms tested. No development of microorganism resistance to dequalin chloride has been reported. As with other surfactants, the main mechanism of action of dequalinium chloride is based on increased cell permeability and subsequent loss of enzyme activity, which leads to cell death. Dequalinium chloride in vaginal tablets exerts its action locally in the vagina. A noticeable decrease in secretions and inflammation usually occurs after 24–72 hours.


Since vaginal absorption is negligible, there is no data on the pharmacokinetics of dequalinium chloride in humans.

Clinical characteristics.


  • Vaginal infections of bacterial and fungal origin (e.g. bacterial vaginosis and candidiasis). trichomoniasis. rehabilitation before gynecological operations and childbirth.


  • Hypersensitivity to the active substance or to any of the excipients. ulcers of the epithelium of the vagina and cervix. childhood.

Interaction with other drugs and other types of interactions.

Interactions with other drugs are unknown.

If necessary, the simultaneous use of any medications should consult with your doctor.

Femiclin is incompatible with soap and other anionic surfactants.

Features of the application.