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Composition:


active ingredient: chlorhexidine gluconate;


1 pessary contains chlorhexidine gluconate (20 %) 85.2 mg, in terms of 100% chlorhexidine 16 mg;


excipients: macrogol 1500, macrogol 400.


Dosage form. Pessaries.


Basic physical and chemical properties: white or white pessaries with a yellowish tinge of color, marbling of the surface is allowed. An air rod or funnel-shaped depression is allowed on the cut.


Pharmacotherapeutic group.


Antimicrobial and antiseptic agents used in gynecology. ATX code G01A X.


Pharmacological properties.


Pharmacodynamics. Chlorhexidine gluconate has a rapid and pronounced effect on Gram-positive and Gram-negative bacteria: Treponema pallidum, chlamydia spp., Ureaplasma spp., Neisseria dopoghoeae, Trichomonas vaginalis. Some strains of Pseudomonas spp are weakly sensitive to the drug., Proteus spp. Acid-resistant forms of bacteria, bacterial spores, fungi, and viruses are not sensitive to the drug.


Pharmacokinetics. When used intravaginally, it is practically not absorbed, and has no systemic effect.


Clinical characteristics.


Indications.


For the Prevention of sexually transmitted diseases (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis) and infectious and inflammatory complications in obstetrics and gynecology (before surgical treatment of gynecological diseases, before childbirth and abortion, before and after the installation of an intrauterine device, before and after diathermocoagulation of the cervix, before intra-uterine studies).


For the treatment of bacterial vaginosis, colpitis, cervical erosion.


Contraindications.


Individual hypersensitivity to the components of the drug.


Interactions with other drugs and other types of interactions.


Chlorhexidine should not be used together with detergents that contain anionic group (saponins, sodium lauryl sulfate, sodium carboxymethylcellulose), as well as with soap. The presence of soap can inactivate chlorhexidine, so the remaining soap must be thoroughly washed off before using the drug. Toilet of the external genitalia does not affect the effectiveness and tolerability of suppositories, because the drug is used intravaginally. Concomitant use with iodine is not recommended.


Application features.


Exposure to hypochlorite bleach on fabrics that have previously been in contact with a product containing chlorhexidine can contribute to the appearance of brown spots on the fabric.


Use during pregnancy or lactation. Not contraindicated.


Ability to influence the reaction rate when driving vehicles or other mechanisms. It doesn't affect you.


Dosage and administration.


The drug is used intravaginally. Before use, the pessary is released from the contour packaging.


Treatment: apply 1 pessary 1-2 times a day for 7-10 days, depending on the nature of the disease. If necessary, it is possible to extend the course of treatment for up to 20 days.


Prevention of sexually transmitted diseases: apply once for 1 pessary no later than 2 hours after sexual intercourse.


Pregnancy. Taking into account the severity of the infectious process, data from bacteriological studies, the phenomenon of the threat of termination of pregnancy, the drug is used 1 pessary 1 or 2 times a day as monotherapy or as part of complex therapy. The duration of application is from 5 to 10 days.


When breastfeeding, the drug is used in the usual recommended doses.


Children.


The drug is not used in children.


Overdose.


Overdose and toxic effects were not detected when using the drug.


Adverse reactions.


Possible allergic reactions, itching at the site of administration of pessary.


Possible burning and irritation at the pessary injection site.

Tags: Chlorhexidine