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Pharmacological properties

combination preparation consisting of 2 components. chlorhexidine has an antibacterial effect by non-specific binding to phospholipids of the bacterial cell membrane, where chlorhexidine inhibits the activity of dehydrogenase and atphase and disrupts the membrane permeability to potassium, nucleotides and amino acids.

Chlorhexidine acts as a bacteriostatic drug in low concentrations (20 mg / l) and as a bactericidal drug in high concentrations. Its action is directed mainly against gram-positive microorganisms and Candida albicans and to a lesser extent against gram-negative microorganisms. Chlorhexidine is especially effective against Streptococcus mutans, Streptococcus salvarius, Escherichia coli, Selenomonas, anaerobic bacteria and Candida albicans. Less effective against Streptococcus sanquis, Proteus, Pseudomonas, Klebsiella and Veillonella species.

Ascorbic acid reduces inflammation and swelling of the mucous membrane of the mouth and nasopharynx, enhances the immune response and acts as a cofactor in the synthesis of collagen and tissue regeneration.

Pharmacokinetics Chlorhexidine is practically not absorbed through the mucous membrane and skin. During resorption, chlorhexidine is gradually excreted from the tablets into saliva and binds to the mucous membrane of the oral cavity and tongue, after which it again enters the saliva, where its antibacterial effect is manifested. Chlorhexidine can enter the digestive tract with saliva, but its absorption from the digestive tract is very low. Chlorhexidine is slightly metabolized in the liver and excreted in the bile through the intestines. Typically, 90% of chlorhexidine taken is excreted unchanged with feces.

The concentration of chlorhexidine in body fluids is measured by high performance liquid chromatography with a sensitivity of up to 1 mg / l.

Ascorbic acid is well absorbed in the digestive tract. The degree of its binding to plasma proteins is approximately 25%. Ascorbic acid is metabolized to dihydroascorbic and oxalic acids, excreted mainly in the urine.

Indications

Local treatment of symptoms of inflammation of the mucous membrane of the throat and larynx.

Application

In adults and children over the age of 12 years: dissolve 1 tablet 4 times a day (every 6 hours).

The tablet should be taken after eating and brushing your teeth.

It is recommended that you do not rinse your mouth and do not drink plenty of fluids for 2 hours after taking the tablets.

Contraindications

Hypersensitivity to chlorhexidine or other components of the drug.

Side effects

Allergic reactions are possible, including nasal congestion, skin rash, peeling of the oral mucosa, and edema of the parotid glands. note a change in taste, an increase in plaque, discolouration (brown spots) on teeth, fillings and dentures, irritation or inflammation of the oral mucosa, irritation of the gastric mucosa and diarrhea.

The drug contains Ponso 4R dye (E124), which can cause allergic reactions in people with hypersensitivity.

special instructions

The use of the drug may temporarily slightly change the taste, but within 4 hours after taking the drug, the taste perception is fully restored. taking the drug is recommended after eating.

Farington should not be taken for more than 14 days, on average, apply within 5-7 days.

Due to the fact that the preparation contains sugar, it should be used with caution in patients with diabetes mellitus and in patients with a tendency to caries.

Long-term use of Farington may cause a slight temporary change in the color of the teeth and tongue, but these phenomena disappear after discontinuation of the drug or a doctor’s consultation may be necessary to eliminate them.

Sometimes patients with diseases of the gastrointestinal tract and / or liver may experience nausea, vomiting, and burping. If these symptoms appear, the drug should be discontinued.

Use during pregnancy and lactation.Studies on the effects of chlorhexidine on pregnant women have not been conducted. In animal studies using doses of chlorhexidine many times higher than what a person could take, an embryotoxic effect has not been established. However, a pregnant woman should consult a doctor before taking the drug.

The penetration of chlorhexidine into breast milk has not been studied. Ascorbic acid is excreted in milk. A woman who is breastfeeding should consult a doctor before taking Farington.

Children. The drug is recommended for use in children over the age of 12 years.

Influence on the ability to drive vehicles or work with other mechanisms. The drug is completely safe and does not affect the psychophysical ability of vehicles or to work with complex mechanisms.

Interactions

There are no reports of interactions with other drugs.

Overdose

The drug is practically not absorbed in the digestive tract, so its overdose is unlikely. in case of a possible overdose of the drug, symptomatic treatment is indicated.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° c.

Tags: Ascorbic acid, Chlorhexidine