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Pharmacological properties

Pharmacodynamic parameters. Framycetin is a broad-spectrum aminoglycoside antibiotic for topical use. exposure to framycetin disrupts the synthesis of proteins that are vital for the functioning of a bacterial cell, which leads to the death of the microorganism.

Topical therapy with framycetin creates concentrations that have a bactericidal effect, aimed at both gram-positive and gram-negative microorganisms - pathogens of upper respiratory tract infections.

Sensitivity to corynebacterium framycetin, Branhamella catarrhalis, methicillin-sensitive staphylococci, acinetobacteria (mainly Acinetobacter baumanii), E. coli, campylobacter, representatives of the genus citrobacter, Enterobacterium enterobacterium, Enterobacterium enterobacterium, Enterobacterium enterobacterium, Enterobacterium colobacterobacterium, Enterobacterium enterobacterium, Enterobacterium inferiorum), proteoses (Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri); Klebsiella, Salmonella, Shigella, Yersinia and Serration are also sensitive.

Moderately pronounced activity of framycetin against pathogens of pasteurellosis is noted.

Enterococci, streptococci, methicillin-resistant staphylococci (more hospital strains), Pseudomonas aeruginosa, Nocardia asteroides, flavobacteria, Alcaligenes denitrificans, Providencia stuartii, burkholderia, bacterium bacteria, malaria bacteria, maloperium bacteria, oxygen.

Indications

  • Diseases of the upper respiratory tract of an infectious-inflammatory nature (as part of a combination treatment): rhinitis, rhinopharyngitis, sinusitis (in case of intact paranasal sinus walls); inflammatory processes after surgery (therapy and prevention).

Application

1 injection in each nasal passage (adults - 4-6 times a day, children over the age of 1 year - 3 times a day). course - up to 10 days.

When using, observe the vertical position of the vial; the patients head should be tilted forward slightly.

Contraindications

  • Hypersensitivity to framycetin (as well as other aminoglycosides) or other components of the drug; children at the age of 1 year.

Side effects

In rare cases, allergic reactions are possible: skin itching, urticaria.

special instructions

Do not use as a means for washing the paranasal sinuses.

In a situation of prolonged use of the drug, the development of antibiotic-resistant strains of microorganisms is likely.

If there is no effect of therapy within 7 days, you should stop using the drug.

Do not use during pregnancy and lactation.

No effect on the reaction rate was noted when driving vehicles or other mechanisms.

Interactions

No data available.

It is necessary to inform the doctor if the patient uses any other topical preparations.

Overdose

Not found.

Storage conditions

At a temperature of ≤25 ° C out of the reach of children.

Tags: Isofra® [Framycetin sulfate]