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Pharmacological properties

Soledum for children and Soledum forte - an anti-inflammatory and mucolytic drug used as adjunctive therapy for respiratory diseases.

Cineol is the main component of eucalyptus oil. It stimulates expectoration and secretion, and also has a weak hyperemic and local anesthetic effect. Clinical studies have shown increased mucociliary clearance with cineol in the therapeutic dose range. It is believed that an expectorant effect is associated with a positive effect on subjective parameters such as sputum and shortness of breath. In addition, a weak antispasmodic effect of cineol was noted. An in vitro study revealed inhibition of the synthesis of leukotriene B4 in monocytes and inhibition of other inflammatory mediators. Hyperresponsiveness of the bronchi was reduced.

Pharmacokinetics Data on cineol metabolism were obtained only in animal experiments. In rabbits, cineole is metabolized to 2- and 3-hydroxy-cineole-glucuronide. There are no data on the biological effectiveness of metabolites. Cineol in a significant amount is absorbed in the digestive tract. The drug is partially excreted with exhaled air by the lungs and partially excreted by the kidneys after hepatic metabolism. In rodents, the drug in high doses induces the induction of microsomal enzymes.

Indications

As part of a comprehensive treatment for symptoms of bronchitis and viral infections of the respiratory tract.

Concomitant therapy of chronic and inflammatory diseases of the respiratory tract (e.g., sinuses).

Application

Soledum capsules for children should be swallowed whole, washed down with a sufficient amount of liquid of moderate temperature (preferably with one glass [200 ml] of drinking water), ≈30 min before eating. patients with hypersensitivity to the stomach are recommended to use the drug Soledum during meals.

The duration of therapy depends on the nature and severity of the course of the disease.

For patients with diabetes, it should be borne in mind that one Soledum capsule for children is equivalent to 0.0013 XE.

Age Single dose Total daily dose
Children aged 8–12 years (≈25–43 kg) 1 capsule (equivalent to 100 mg of cineol) 3 capsules (equivalent to 300 mg of cineol)
Children aged 2–8 years (≈13–24 kg) 1 capsule (equivalent to 100 mg of cineol) 3 capsules (equivalent to 300 mg of cineol)

For children aged 2-12 years, take 1 capsule 3 times a day.

Due to the lack of sufficient scientific data on the use of the drug in children under the age of 8 years, treatment should be carried out under the supervision of a doctor.

Soledum forte capsules should be swallowed whole, washed down with a sufficient amount of moderate temperature liquid (preferably with one glass [200 ml] of drinking water) ≈30 min before eating. Patients with increased gastric sensitivity are recommended to use the drug Soledum forte during meals.

The duration of therapy depends on the nature and severity of the course of the disease.

Age Single dose Total daily dose
Children from 12 years old and adults 1 capsule (equivalent to 200 mg of cineol) 2–4 capsules (equivalent to 400–800 mg of cineol)

Adults should take the drug 1 capsule 3 times a day.

In case of severe disease, the dose can be increased to 1 capsule 4 times a day. With prolonged and continuous treatment, usually 1 capsule 2 times a day is usually enough.

For patients with diabetes mellitus, it should be borne in mind that 1 capsule of Soledum forte is equivalent to 0.0015 XE.

Contraindications

The drugs are contraindicated for persons with established hypersensitivity to the active substance cineol or to any of the excipients of the drug, in case of disease with whooping cough or false croup.

The drug Soledum for children is contraindicated in children under the age of 2 years. The drug Soledum forte is contraindicated in children under the age of 12 years.

Side effects

Adverse reactions are given below in accordance with the frequency of occurrence: very often (≥1 / 10), often (≥1 / 100 to 1/10), infrequently (≥1 / 1000 to 1/100), rarely (≥

Tags: Soledum® [Cineol]