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Pharmacological properties

Tetrizoline, when applied topically, stimulates the α-adrenergic receptors of the sympathetic nervous system, which causes vasoconstriction with a decrease in tissue edema; reduces the severity of burning, irritation, itching, soreness and lacrimation.

The vasoconstrictor effect develops several minutes after instillation into the eye and lasts up to 4 hours.

Tetrizoline is practically not absorbed when applied topically in therapeutic doses.


Symptomatic treatment for edema and secondary hyperemia due to moderate irritating effects on the conjunctiva of smoke, dust, chlorinated water, an allergic reaction, nonspecific or catarrhal conjunctivitis.


Do not screw the cap tightly before use!

Screw the cap as far as possible before first use. In this case, the spike, which is located on the inside of the cap, punctures the hole in the bottle. Immediately before use, you should hold the bottle in the palm of your hand to warm it to body temperature.

Unscrew the cap, remove it, and, having slightly pressed on the body of the bottle, put the solution into the eyes (conjunctival cavity).

In order to avoid spontaneous leakage of the solution during storage after instillation of the drug, screw the cap tightly so that the spike that is on the inside of the cap closes the hole in the bottle. Store the drug in accordance with the recommendations specified in the STORAGE CONDITIONS section (in an upright position).

Vial is for topical use only.

Adults and children over the age of 6 years are instilled with 1-2 drops in the conjunctival sac of the affected eye (s) 2 or 3 times a day.

For children under the age of 6, the drug is used only under the supervision of a doctor.

Continuous use of the drug is recommended no more than 72 hours in a row.


  • Hypersensitivity to tetrizolin or other components of the drug, angle-closure glaucoma, epidermal-endothelial dystrophy of the cornea, age up to 2 years.

Side effects

Systemic effects are usually not observed.

After the use of the drug Vial, isolated side effects are noted: a burning sensation, pain, irritation of the conjunctiva, reactive hyperemia, in rare cases, mydriasis.

Sometimes sympathomimetic effects may occur (increased and rapid heartbeat, increased blood pressure, narrowing of blood vessels).

Individual intolerance to the drug is possible.

special instructions

Vial should only be used with mild eye irritation.

Before applying the drops, children aged 2 to 6 years need to consult a doctor.

If signs of eye irritation persist for 48 hours, discontinue use of the drug. If irritation or redness is associated with serious diseases of the organ of vision (e.g. infection, foreign body or chemical trauma to the cornea), then the patient is also advised to consult a doctor. If intense pain in the eyes, headache, rapid loss of vision, sudden appearance of spots that “float” in front of the eyes, redness of the eyes, pain in the eyes when doubled in the eyes or in the eyes begins to double, you should immediately consult a doctor.

It is necessary to avoid prolonged use of the drug and overdose, especially in children.

Contact lenses should be removed before instilling the drug, given the possibility of reducing their transparency.

Very frequent use of the drug can cause redness of the eyes.

Patients with severe cardiovascular diseases (IHD, AH), pheochromocytoma, metabolic disorders (hyperthyroidism, diabetes mellitus), as well as patients using MAO inhibitors or other drugs that can increase blood pressure, should be prescribed the drug only in those cases when the potential benefit exceeds the potential risk.

Vial can be used in combination with other eye drops no earlier than 15 minutes after instillation of the drug.

Use during pregnancy or lactation. Given the insignificant possibility of the development of general reactions, it is possible to use the drug during pregnancy or breastfeeding only when, in the opinion of the doctor, the expected benefit for the mother outweighs the possible risk to the fetus / child.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Sometimes after the use of the drug, pupil dilates and blurred vision occurs, in such cases, driving or working with other mechanisms is recommended after restoring the clarity of vision.

Children. Contraindicated in children under 2 years of age.


Do not mix vial eye drops with any other drops. tetrizoline is incompatible with MAO inhibitors.

Direct contact with soft contact lenses should be avoided, given the risk of impaired transparency.


When used according to the instructions, an overdose of eye drops is not possible.

An overdose due to swallowing or excessive use of the drug can cause bradycardia, drowsiness, arterial hypotension, lethargy, and a decrease in body temperature. In addition, when drops are swallowed, apnea, CNS depression and coma can occur.

Symptomatic and supportive therapy is performed. In the treatment of overdose or when swallowing the drug, activated charcoal is used and the stomach is washed. The specific antidote is unknown.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

Tags: Tetrahydrozoline