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Pharmacological properties

Medetrom is a combination of GCS with an antimicrobial agent. dexamethasone is a corticosteroids that helps prevent or reduce inflammation of the eye. tobramycin is an antimicrobial active against a wide range of microorganisms that can infect the eye.

Indications

Inflammation of the eyes in steroid-sensitive patients who are indicated for the use of corticosteroids and there is a superficial bacterial infection or a risk of developing a bacterial infection of the eye. these inflammatory processes may occur after surgery or may be caused by infection, foreign body contact with the eye, or eye injury.

Application

Medetrometer is used only for instillation into the eye.

Use in adults and children over the age of 1 year. Standard dosage: 1-2 drops in the eye every 4-6 hours. The duration of treatment is determined by the doctor.

Rules for the use of the drug. Before using the drug, wash your hands. Shake the bottle well and unscrew the cap. To tilt the head back, to pull the lower eyelid with a clean finger to form a sac between the eyelid and the eye. A drop should get there. Raise the tip of the vial to the eye. You can use a mirror. Do not touch the dropper on the eye or eyelid, or other surfaces (this may contaminate the drops). Gently press the bottle to release 1 drop of the drug. After applying the drops, release the lower eyelid, close the eye and gently press with your finger on the inner corner of the eye near the nose. This will prevent the systemic effect of the drug. If necessary, repeat the same procedure for the other eye. Immediately after use tightly screw the cap onto the bottle.

Only one vial should be used at a time.

If a drop does not get into the eye, repeat the procedure.

If a larger than necessary dose of the drug is instilled, it is necessary to rinse the eye with warm water and do not use the drug more until the next dose is instilled.

If you forgot to use the drug, you should drip a single dose as soon as you remember. But if it is time for the next dose, then you should skip the one that you forgot about and return to normal mode. Do not use a double dose.

When using other eye preparations, it is necessary to take a break of 10-15 minutes between taking them.

Contraindications

Hypersensitivity (allergic reaction) to tobramycin and / or dexamethasone or any other components of the drug;

  • untreated purulent infection of the eye;
  • viral infection of the eye (epithelial keratitis caused by the Herpes simplex virus, which is a superficial infection of the eye and is characterized by tree ulcers on the surface of the eye);
  • cowpox (smallpox), chickenpox (chickenpox) or other viral infection of the eye (except keratitis caused by Herpes zoster virus);
  • fungal diseases of the eye structures;
  • mycobacterial infections of the eye (eye tuberculosis).

Side effects

When using the drug, the following side effects are possible. within each group, side effects are presented in decreasing order of severity.

Organ systems MedDRA Side Effects
From the nervous system Dysgeusia (bitter or unusual taste in the mouth), headache, dizziness
On the part of the organ of vision Discomfort in the eye, eye pain, eye irritation, allergy with localization in the eye (hypersensitivity), increased intraocular pressure, keratitis, spot keratitis, eye hyperemia, itching of the eye, itching of the eyelid, erythema of the eyelid, blurred vision, sensation of a foreign body in the eye, conjunctival edema, dry eye, eyelid edema, increased lacrimation, glaucoma, cataracts, decreased visual acuity, mydriasis, photophobia
From the respiratory system Laryngospasm, rhinorrhea
From the gastrointestinal tract Nausea, vomiting
On the part of the skin and subcutaneous tissue Rash, swelling of the face, itching, erythema

Side effects that occurred when using combined drugs containing a steroid and antimicrobial component can be associated with either a steroid or antimicrobial component, or a combination thereof.

Medetrom contains tobramycin and dexamethasone. Side effects associated with the use of certain components that may occur when taking the drug are:

Organ systems Tobramycin 3 mg / ml Dexamethasone 1 mg / ml
From the nervous system   Headache
On the part of the organ of vision Hyperemia of the eye, eye pain, itching of the eye, discomfort in the eye, allergies with localization in the eye, swelling of the eyelid, conjunctivitis, hypersensitivity to bright light, increased lacrimation, keratitis Eye irritation, hyperemia of the eye, erythema of the eyelid, abnormal sensitivity of the eye
From the respiratory system   Nasopharyngeal drip

If systemic antibiotics of the aminoglycoside group are used in combination with topical ophthalmic use of tobramycin, the total plasma concentration should be regularly monitored.

Due to the steroid component in the presence of diseases leading to thinning of the cornea or sclera, there is a high risk of perforation, especially after prolonged use.

The development of a secondary infection was noted after the use of a combination of steroids and antimicrobial agents. Fungal infections of the cornea are especially active during prolonged use of steroids. The possibility of fungal invasion in any persistent ulceration of ro