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Pharmacological properties

Cromopharm is an antiallergic agent that prevents intracellular penetration of calcium ions, stabilizes the membranes of basophils, inhibiting their degranulation, thereby helping to prevent the release of mediators of allergic inflammation: histamine, bradykinin, leukotrienes and other biologically active substances. this mechanism of action is universal for all mucous membranes (bronchi, nose, eyes, intestines). the drug protects against the influence of specific allergens (dust, pollen) and other irritating environmental factors.

Pharmacokinetics Absorption of cromolyn sodium in the blood is negligible. The main factor in ensuring the therapeutic effect of the drug is the concentration of cromolyn sodium, which is achieved in the target organ after topical application. T½ is 80 minutes

Sodium cromoglycate is poorly soluble in lipids and therefore is not able to penetrate biological membranes, including through the BBB. Cromolyn sodium is not metabolized. The drug is excreted in equal amounts with urine and bile for 24 hours unchanged.

Indications

Prevention and treatment of acute and chronic allergic conjunctivitis, including hay conjunctivitis and spring keratoconjunctivitis.

Application

Adults and children over the age of 4 years old should be instilled 1 drop in each eye 4 times a day. in some acute cases, the drug can be instilled more often - 1 drop up to 6-8 times a day. with improvement, the frequency of instillation can be reduced.

Treatment with Cromofarm should be continued until the patient ceases to contact the allergen that caused the disease.

In seasonal allergic conjunctivitis, treatment should be started immediately after the onset of the first symptoms or used prophylactically until pollen appears.

The duration of use depends on the type and severity of the disease.

Attention! Do not screw the cap tightly before use! Before the first use, the cap of the bottle is screwed as much as possible. In this case, the spike, which is located on the inside of the cap, punctures the hole. Immediately before use, you should hold the bottle with the drug in the palm of your hand to warm it to body temperature. The cap is unscrewed, removed and, slightly pressing on the body of the bottle, the solution is instilled into the eye. After instillation of the drug, the cap is tightly screwed and the drug is stored according to the recommendations specified in the instructions.

Contraindications

Hypersensitivity to cromolyn sodium and other components of the drug, children under 4 years of age.

Side effects

From the side of the organ of vision: irritation of the mucous membrane of the eye, conjunctival hyperemia, sensation of a foreign body in the eye, lacrimation, dryness, rash on the skin around the eyes, conjunctival edema, visual impairment, blepharitis, burning sensation and tingling in the eye, passing independently through 1-3 min and not leading to pathological changes in the conjunctiva or clinically significant deviations.

In patients with hypersensitivity, hypersensitivity reactions are possible.

From the respiratory system: dyspnea.

Eye drops contain a benzalkonium chloride preservative, which can cause an adverse reaction in the form of hypersensitivity to this component and change taste sensations.

With the development of side effects, you should consult your doctor.

With prolonged use, it is necessary to regularly monitor the functional state of the liver and kidneys.

special instructions

In acute inflammation and during an exacerbation of the chronic process, the drug should be used in combination with antihistamines or corticosteroids. the patient should be warned about the need for regular use of the drug.treatment begins before contact with the allergen and continues throughout the duration of the allergen.

In case of violation of the integrity of the vial, as well as with turbidity of the solution, the drug should not be used.

When using eye drops, soft contact lenses cannot be used due to the presence of chloride in benzalkonium. Hard contact lenses should be removed from the eyes immediately before instillation of the drops and inserted no earlier than 15 minutes after application of the drug.

Use during pregnancy and lactation. Sodium cromoglycate is excreted in breast milk in an insignificant amount, therefore, when using the drug during lactation, the risk of harmful effects on young children is minimal or practically absent. However, the use of the drug during pregnancy, especially in the first trimester, or during lactation is recommended only when the expected benefit to the mother outweighs the potential risk to the fetus or child.

Children. Do not use in children under 4 years of age. Treatment with children over 4 years of age is possible only as directed by a doctor.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. For some time after instillation in the eyes, one should refrain from performing work that requires increased attention due to possible short-term visual impairment.

Interactions

Sodium cromoglycate mutually enhances the effect of other anti-allergic and anti-asthmatic drugs: β-adrenergic agonists, corticosteroids, antihistamines and theophylline.

Overdose

Cases of overdose have not been established, but with an overdose, an increase in adverse reactions is possible. symptomatic treatment.

Storage conditions

In the dark place at a temperature of 15-25 ° c.

Tags: Cromoglycate Sodium