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ALZMERAT Injection 250 mg

Instruction manual

For medical use of the drug

Alzmerat

(alzhmerat)

Structure:

Active ingredient: choline alfoscerate;

1 ml of the solution contains choline alfoscerate 250 mg;

excipient: water for injection.

Dosage form.

Injection.

Basic physical and chemical properties: colorless or yellowish transparent liquid.

Pharmacotherapeutic group.

Means that affect the nervous system. parasympathomimetics. choline alfoscerate. code atx n07a x02.

Pharmacological properties.

Alzmerate is a drug that belongs to the group of central cholinomimetics with a primary effect on the central nervous system. Alzmerate as a choline carrier and the previous phosphatidylcholine agent has the potential ability to prevent and correct biochemical damage, which is of particular importance among pathogenic factors of the psycho-organic involution syndrome, that is, it can affect the reduced cholinergic tone and the altered phospholipid composition of the membranes of nerve cells. 40.5% of the drug consists of a metabolically protected choline. metabolic protection provides the release of choline in the brain. Alzmerate has a positive effect on memory functions and cognitive abilities, as well as on indicators of emotional state and behavior, the deterioration of which was caused by the development of involutional brain pathology.

The mechanism of action is based on the fact that when choline enters the body, alfoscerate breaks down under the action of enzymes on choline and glycerophosphate: choline takes part in the biosynthesis of acetylcholine, one of the main mediators of nervous excitation; glycerophosphate is a precursor of phospholipids (phosphatidylcholine) of the neural membrane. Thus, Alzmerat improves transmission of nerve impulses in cholinergic neurons; positively affects the plasticity of neuronal membranes and receptor function. Alzmerat improves cerebral blood flow, enhances metabolic processes in the brain, activates the structure of the reticular formation of the brain and restores consciousness in traumatic brain damage.

Pharmacokinetics When administered, on average about 88% of the dose is absorbed. The drug accumulates mainly in the brain (45% of the concentration of the drug in the blood), lungs and liver. Withdrawal of the drug occurs mainly through the lungs in the form of carbon dioxide (CO2) Only 15% is excreted in urine and bile.

Clinical characteristics.

Indications.

An acute period of severe traumatic brain injury with a predominantly stem damage level (impaired consciousness, coma, focal hemispheric symptoms, symptoms of damage to the brain stem).

Degenerative-involutional brain psycho-organic syndromes or secondary consequences of cerebrovascular insufficiency, that is, primary and secondary mental disorders in the elderly, which are characterized by impaired memory, confusion, disorientation, decreased motivation and initiative, decreased ability to concentrate; changes in the emotional sphere and the sphere of behavior: emotional instability, irritability, indifference to the environment; pseudomelancholy in the elderly.

Contraindications

Hypersensitivity to the drug or to its components.

During pregnancy and breastfeeding.

Psychotic syndrome, with severe psychomotor agitation.

Interaction with other drugs and other types of interactions.

Clinically significant interaction of the drug with other drugs has not been established.

Features of the application.

Use during pregnancy or lactation.

The drug is contraindicated during pregnancy and during lactation.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

The drug does not affect driving and working with other mechanisms.

Dosage and administration.

In acute conditions, alzmerate is administered intramuscularly or intravenously (slowly) in 1 g (1 ampoule) for 15 to 20 days. then, after stabilization of the patients condition, they switch to the dosage form of the drug in capsules.

Children.

There is no experience with the use of alzmerate in children.

Overdose.

In case of an overdose of choline with alfoscerate, which can be manifested by nausea, the dose of the drug should be reduced. symptomatic therapy.

Adverse Reactions

As a rule, the drug is well tolerated even with prolonged use. nausea (which is mainly the result of secondary dopaminergic activation) is possible, abdominal pain and short-term confusion are very rare. in this case, it is necessary to reduce the dose of the drug.

Possible reactions at the injection site. During the first days or weeks of treatment, such manifestations of adverse reactions may occur: anxiety, agitation, insomnia. These symptoms are temporary and do not require discontinuation of treatment, but a temporary dose reduction is possible.

Hypersensitivity reactions are possible, including rash, itching, urticaria, angioedema, and redness of the skin.

Shelf life.

3 years.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Incompatibility.

It should not be used in the same container with other medicines.

Packaging.

4 ml per ampoule; 5, 10 or 100 ampoules in a pack, or 5 ampoules in a blister; 1 or 2 blisters in a pack.

Vacation category.

On prescription.

Manufacturer.

Private joint-stock company "lekkhim-kharkov".

The location of the manufacturer and his address of the place of business.

Ukraine, 61115, Kharkiv region, Kharkiv city, Severin Pototsky street, 36.

Tags: Choline alfoscerate