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Pharmacological properties

A combined preparation for external use, the pharmacological properties of which are due to the mutual potentiation of the therapeutic effect of each of the components. An important component is bee venom, obtained from live bees and isolated in its pure form by lyophilization. To ensure the continued effectiveness of this biological substance, bee venom is standardized and investigated during biochemical and pharmacological tests. standardized bee venom contains active ingredients that have a versatile therapeutic effect. the most important of them are mellitin, histamine, peptide MSD, hyaluronidase, phospholipase. the second component of the ointment - methyl salicylate - belongs to the group of NSAIDs. penetrates well through the skin, has an anti-inflammatory and analgesic effect, intensified due to the synergistic effect of the components of bee venom - peptide MSD and apamine. the third component, allylisothiocyanate, has a local irritant effect, causing local hyperthermia and hyperemia, which are amplified by the effects of bee venom ingredients - histamine and mellitin. Mellitin also promotes the release of the endothelial relaxing factor (edrf). Improving local blood circulation leads to improved oxygen supply to the tissues and accelerates the elimination of toxic metabolic products from the focus of inflammation, causing a sensation of pain.

Indications

Inflammatory and degenerative joint diseases (arthritis, including rheumatism, arthrosis); myalgia, pain with traumatic injuries of muscles, tendons, ligaments; neuralgia, neuritis, sciatica, lumbago, sciatica; peripheral circulatory disorders; as a warming agent in sports medicine.

Application

Adults and children over 6 years of age, depending on the size of the painful area, apply a strip of ointment 3-5 cm long, evenly distribute it with a thin layer and expect a reaction (hyperemia, sensation of heat, burning) that develops after 0.5– 1 min depending on individual sensitivity. then slowly and intensively rub the ointment into the skin. body parts treated with ointment are recommended to be kept warm. usually the drug is used daily 2-3 times a day until the symptoms disappear.

Contraindications

Hypersensitivity to the components of the drug. skin diseases, acute inflammation of the joints, renal failure. children under the age of 6 years.

Side effects

In isolated cases - allergic reactions.

special instructions

Do not allow ointment to enter the mucous membrane or open wounds.

Use during pregnancy and lactation. It is not recommended to use the ointment during pregnancy and lactation.

Children. The drug is not prescribed for children under 6 years of age due to insufficient experience with this category of patients.

The ability to influence the reaction rate when driving vehicles or working with mechanisms. Does not affect.

Interactions

Not marked.

Overdose

Symptoms: skin irritation.

Treatment. Drug withdrawal. Symptomatic Therapy

Storage conditions

At a temperature not exceeding 25 ° C.

Tags: Apizartron