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Pharmacological properties

chondroitin sulfate has a chondroprotective, chondrostimulating, regenerating, anti-inflammatory and analgesic effect. improves phosphorus-calcium metabolism in cartilage, inhibits enzymes that disrupt the structure and function of articular cartilage, inhibits the degeneration of cartilage. stimulates the synthesis of glucosaminoglycans, normalizes the metabolism of hyaline cartilage, promotes the regeneration of cartilage surfaces and articular bags. with external use, the drug slows the progression of osteoarthritis, reduces inflammation and pain in the affected joints.

Menthol has a local irritating, analgesic, distracting, antiseptic, soothing effect. The effect is mainly due to reflex reactions associated with irritation of sensitive nerve endings: irritation of the skin receptors stimulates the formation and release of endogenous biologically active substances (enkephalins, endorphins, peptides, kinins) involved in the regulation of pain, vascular permeability and other processes that provide painkiller and distracting action. Annoying (distracting) effect helps to reduce pain. The menthol effect develops quickly and is accompanied by a feeling of warmth. Skin-visceral reflexes improve trophic tissue (corresponding to the innervation zones).

Pharmacokinetics The pharmacokinetics of chondroitin sulfate during cutaneous use has not been studied.

With cutaneous application of drug Cmax in blood plasma is reached after 3-4 hours, in synovial fluid - after 4-5 hours after application.

Bioavailability is 13%. It is excreted by the kidneys within 24 hours.

Indications

Degenerative-dystrophic diseases of the joints and spine (mainly localized forms): osteoarthrosis, osteochondrosis.

Application

The drug is used externally. apply the ointment 2-3 times a day with a thin layer on the skin in the affected area, easily rubbing until completely absorbed. after rubbing the ointment, a warming dressing can be applied to enhance the effect.

The duration of the course of treatment is determined individually depending on the effectiveness and tolerability of therapy and, as a rule, is 2-3 weeks. If necessary, repeat the course.

Contraindications

Individual hypersensitivity to the components of the drug. thrombophlebitis, tendency to bleeding, acute inflammatory processes at the site of application of the drug.

Side effects

Skin allergic reactions: itching, hyperemia, burning, rash, which may occur at the site of application.

special instructions

When rubbed into the skin, it causes a slight sensation of cold, then warmth, a slight burning sensation and tingling sensation.

The drug should be applied only to intact skin areas, it is necessary to avoid getting the drug on open wounds, in the eyes and on the mucous membranes.

Use during pregnancy and lactation. The safety and effectiveness of the drug during pregnancy and lactation have not been established, therefore, the drug can only be used if, in the opinion of the doctor, the benefits of the application outweigh the risk.

Children. The drug should not be used to treat children due to lack of sufficient clinical experience.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect.

Interactions

With the cutaneous use of the drug, its interaction with other drugs has not been established.

Overdose

Cases of drug overdose are not described. there are cases of hypersensitivity that require discontinuation of the drug and symptomatic therapy.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° c.

Tags: Levomenthol, Chondroitin Sulfate