- Available:In stock1390
- Availability date:2020-07-30
- Dosage form:Tablets
- In stock:1390 Items
mechanism of action. orgametril - a preparation for oral administration. the composition of the drug includes linestrenol (a synthetic progestogen), which has the pharmacological properties of the natural hormone progesterone.
Orgametril has a pronounced progestogen effect on the endometrium. With continuous use of the drug, both ovulation and menstruation are suppressed. Orgametril can be used in conditions whose treatment requires the use of drugs with a pronounced progestagenic effect.
Pharmacokinetics After oral administration, linestrenol is rapidly absorbed and undergoes further transformation in the liver into pharmacologically active norethisterone. The maximum levels of norethisterone in blood plasma are reached 2–4 hours after taking linestrenol. Linestrenol and its metabolites are excreted primarily in the urine and, to a lesser extent, with feces.
Polymenorrhea. menorrhagia and metrorrhagia. individual cases of primary or secondary amenorrhea and oligomenorrhea with insufficient levels of endogenous estrogen. endometriosis. benign breast tumors. individual cases of endometrial carcinoma. inhibition of ovulation, pain during ovulation and menstruation. to delay normal menstruation. as an adjunct to estrogen therapy during the period of peri- and postmenopause, in order to prevent endometrial hyperplasia.
Organametril tablets should be used internally and preferably with water or another liquid.
The missed dose should be taken as soon as possible, except when more than 24 hours have passed after skipping the pill.
|Polymenorrhea||1 tablet per day from the 14th to the 25th day of the cycle|
|Menorrhagia and metrorrhagia||2 tablets for 10 days. In most cases, bleeding stops a few days after the start of treatment. Repeat treatment for three menstrual cycles, taking 1 tablet per day from the 14th to the 25th day of each cycle. If the complaints do not disappear during or after treatment, a further examination of the patient is necessary.|
|Individual cases of primary or secondary amenorrhea and oligomenorrhea with insufficient levels of endogenous estrogen||Treatment should begin with the use of estrogen, for example, 0.02-0.05 mg of ethinyl estradiol per day for 25 days. Along with this, take 1 tablet of the drug Orgametril daily from the 14th to the 25th day of the cycle. In most cases, withdrawal bleeding begins within 3 days after discontinuation of treatment. Estrogen treatment should be resumed on the 5th day of withdrawal bleeding and prolonged until the 25th day of the cycle. Then again from the 14th to the 25th day of the cycle, apply 1 tablet of the drug Orgametril. Such treatment should be repeated for at least one more cycle.|
|Endometriosis||1-2 tablets per day for at least 6 months|
|Benign breast tumors||1 tablet per day from the 14th to the 25th day of the cycle for at least 3-4 months|
|Individual cases of endometrial carcinoma||6-10 tablets per day for a long period|
|Suppression of ovulation, pain during ovulation and menstruation||Treatment with 1 tablet per day is best started on the 1st day of the cycle, but no later than on the 5th day of the cycle. Treatment should be continued for many months (taking the drug daily, without days of admission). If, despite treatment, breakthrough bleeding occurs, the dose should be increased to 2 or 3 tablets per day for 3-5 days|
|To delay normal menstruation||Treatment with 1 tablet per day is best started 2 weeks before the expected onset of menstruation. If the course of treatment is started less than 1 week before the expected start of menstruation, the dose should be 2-3 tablets per day. In this case, a delay of more than 1 week is undesirable. If the treatment is started later, the possibility of breakthrough bleeding increases.Therefore, treatment should not be started later than 3 days before the expected start of menstruation|
|As an addition to estrogen therapy during the period of peri- and postmenopause - with the aim of preventing endometrial hyperplasia||1 tablet per day for 12-15 days per month (for example, during the first 2 weeks of each calendar month). An estrogenic drug should be taken daily, without days of admission, at the minimum effective dose.|
* The first day of the cycle is the first day of menstrual bleeding.
Hypersensitivity to the active substance or any of the excipients that make up the orgametril. pregnancy period or its probability. severe forms of liver disease, such as cholestatic jaundice or hepatitis (or a history of severe liver disease in the absence of normalization of pathologically altered indicators of liver function tests), hepatocellular tumors, rotor syndrome, and cudgel-Johnson syndrome. vaginal bleeding of unknown etiology. conditions that are affected by the use of sex steroid hormones and which first appeared or worsened during pregnancy or during treatment with sex steroid hormones, such as severe itching, cholestatic jaundice, herpes in pregnant women, porphyria and otosclerosis. venous thromboembolic disorders in the active phase.
The frequency of adverse reactions is defined as: often (10%), infrequently (1-10%) and rarely (1%).
From the side of metabolism and nutrition: rarely - weight gain; infrequently or rarely - fluid retention, increased sweating, decreased glucose tolerance and changes in lipoprotein profile.
From the nervous system