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Pharmacological properties

a combined preparation that contains vitamins, macro- and microelements that regulate metabolic processes. the pharmacological effect of the drug is due to its constituent components.

Vitamin A (retinol acetate) provides the correct growth and normal condition of bones and epithelial tissues, vision and the immune system.

Vitamin D (colecalciferol) regulates the metabolism of calcium and phosphorus.

Vitamin E (α-tocopherol acetate) prevents the oxidation of polyunsaturated fatty acids in membranes.

Vitamin B1(thiamine hydrochloride) is a necessary coenzyme in the metabolism of carbohydrates and the transmission of nerve impulses.

Vitamin B2(riboflavin) is part of the FMN and FAD (flavin mononucleotide and flavin adenine dinucleotide), mainly necessary for metabolism.

Vitamin B6(pyridoxine hydrochloride) is necessary for enzymes that take part in the metabolism, as well as for the synthesis of neurotransmitters and hemoglobin.

Vitamin B12(cyanocobalamin) functions as a coenzyme in the synthesis of nucleic acids and, together with folic acid, is involved in metabolic processes.

Nicotinamide (Vitamin PP) is part of the cofactors NAD (H) and NADP (H) and part of the glucose tolerance factor.

Pantothenic Acid (Vitamin B5) functions primarily as part of coenzyme A and is involved in the production of hormones and antibodies.

Folic acid is necessary for cell division and in metabolic processes along with vitamin B12.

Vitamin C (ascorbic acid) is necessary for the growth and normal state of bones, skin, teeth, capillary endothelium and the immune system.

Iron is essential for the functioning of hemoglobin and as part of the oxygen reservoir in the muscles.

Zinc is part of various enzymes, for example, for the synthesis and metabolism of fats and proteins.

Copper is used in metabolic reactions and in protein synthesis.

Manganese is an activator and provides various enzymatic reactions in the body.

Chromium is part of the glucose tolerance factor and is necessary for normal metabolism.

Selenium functions together with vitamin E to protect against oxidation and as an integral part of enzymes.

Iodine is an essential component of thyroid hormones.

Pharmacokinetics Not investigated.

Indications

Prevention of vitamin and mineral deficiency in adults and treatment of children over 4 years of age with insufficient intake of vitamins and minerals associated with improper nutrition and conditions, which are accompanied by an increased need for vitamins and minerals (growth period, illness, recovery period) or with malabsorption (gastrointestinal diseases, diarrhea).

Application

Used in adults and children from the age of 4 years, 1 tablet per day. apply inside with food or immediately after it. tablets should be chewed.

The duration of the course of treatment is determined individually depending on the condition of the patient.

Contraindications

Hypersensitivity to the components of the drug, hypercalcemia, hypercalciuria, renal failure, nephrolithiasis, nephritis, nephrosis, nephrosonephritis, pulmonary tuberculosis (active form), fructose intolerance, glucose-galactose malabsorption syndrome, chronic glomerulonephritis, history of sarcoidosis, history , thrombophlebitis, severe renal impairment, gout, hyperuricemia, phenylketonuria, erythremia, erythrocytosis, thromboembolism, thyrotoxicosis, chronic heart failure, active ulcerative bo a stomach and duodenal gland (due to a possible increase in the acidity of the gastric juice), concomitant use of retinoids, selenium, metabolic disorders of iron or copper.

Side effects

When used in recommended doses, the drug is usually well tolerated, however, in individuals with hypersensitivity, adverse reactions may occur.

From the immune system: allergic reactions, including anaphylactic shock, angioedema, hyperthermia;

on the part of the skin and subcutaneous tissue: skin rashes, urticaria, itching, redness of the skin, bronchospasm;

from the digestive tract: dyspeptic symptoms, nausea, vomiting, stomach pain, belching, constipation, diarrhea, increased secretion of gastric juice, heartburn;

from the nervous system: headache, dizziness, increased irritability, drowsiness;

other: visual impairment, increased sweating, urine staining in yellow is possible.

With prolonged use of the drug in high doses, irritation of the mucous membrane of the digestive tract, arrhythmia, paresthesia, hyperuricemia, decreased glucose tolerance, hyperglycemia, transient increase in activity of AcAT, LDH, alkaline phosphatase, impaired renal function, dryness and cracks in the palms and feet, loss may occur. hair, seborrheic rashes, changes in urine, an increase in calcium in the blood and urine, calcification of soft tissues, kidneys, lungs, blood vessels, a decrease in blood coagulation.

special instructions

Use with caution in case of liver damage, peptic ulcer of the stomach and duodenum in the anamnesis, gallstone disease, chronic pancreatitis, patients with neoplasms, with a history of kidney diseases, tendency to thrombosis and bleeding (hemophilia, thrombocytopenia, thrombocytopenia).

The drug can be used in the usual dose for patients with diabetes mellitus, as well as patients with intolerance to gluten and milk.

It is possible to stain urine in yellow, which is a completely harmless factor and is explained by the presence of riboflavin in the preparation.

Supervit is not recommended for use along with other multivitamins and preparations containing trace elements, since an overdose is possible.

The drug contains lactose, so it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The drug contains iodine, therefore, people with thyroid disease should consult a doctor regarding the advisability of using the drug.

Do not exceed recommended dose.

Use during pregnancy and lactation. Since safety studies of the use of the drug during pregnancy and lactation have not been conducted, it should not be used in this category of patients.

Children. The drug is used in children from the age of 4 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Studies of the effect of the drug on the ability to drive a car or other (potentially dangerous) mechanisms have not been conducted. However, the possibility of developing adverse reactions from the nervous system when using the drug (drowsiness, dizziness) should be considered.

Interactions

Vitamins a and e enhance each others action and are synergists. retinol reduces the anti-inflammatory effect of glucocorticoids. can not be taken simultaneously with nitrites and colestyramine, since they disrupt the absorption of retinol. Vitamin A should not be taken simultaneously with retinoids, since their combination is toxic.

Preparations containing iron inhibit the action of vitamin E. Vitamin E can not be used together with preparations of iron, silver, drugs that have an alkaline environment (sodium bicarbonate, trisamine), indirect anticoagulants (dicumarin, neodicumarin).Alpha-tocopherol acetate enhances the effects of steroidal anti-inflammatory drugs and NSAIDs (sodium diclofenac, ibuprofen, prednisolone).

Vitamin C enhances the action of sulfonamides (risk of crystalluria), penicillin, increases iron absorption, reduces the effectiveness of heparin and indirect anticoagulants. The absorption of vitamin C is reduced while it is used with oral contraceptives.

Vitamin B1, influencing the processes of polarization in the region of neuromuscular synapses, can weaken the curariform effect. PASK, cimetidine, potassium preparations, alcohol reduce the absorption of vitamin B12.

Vitamin B6 weakens the effect of levodopa, prevents or reduces toxic effects that occur with the use of isoniazid and other anti-TB drugs.

Folic acid reduces plasma concentrations of phenytoin, with other antiepileptic drugs, a mutual decrease in clinical effectiveness is possible.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin).

Tricyclic antidepressants, imipramine and amitriptyline inhibit the metabolism of riboflavin, especially in the tissues of the heart.

With simultaneous use with quinine, hemorrhages can intensify. Vitamin D Activity3 may decrease with simultaneous use with phenytoin or barbiturates. The drug slows down the absorption of β-adrenergic blockers and indirect anticoagulants.

In this regard, the drug is recommended to be taken before or 2 hours after taking other drugs. To prevent a decrease in the absorption of thiophosphates or sodium fluoride, it is recommended to take the drug no earlier than 1 hour after taking them.

With the simultaneous use of diuretics of the thiazide group, the risk of hypercalcemia increases. Colestyramine, laxatives (paraffin oil) reduce the absorption of vitamin D3.

With the simultaneous use of antacids containing aluminum, calcium, magnesium, there is a decrease in the absorption of iron, which is part of the drug.

Overdose

Symptoms with an overdose of the drug, it is possible to increase the manifestations of adverse reactions, bloating. with an overdose of iron, nausea, vomiting, diarrhea, abdominal pain, hematemesis, rectal bleeding, lethargy, acute vascular insufficiency are possible. hyperglycemia and acidosis may also occur.

Vitamin D overdose3 leads to a violation of the cardiovascular system and kidneys.

Treatment. If signs of an overdose appear, the use of tablets should be discontinued. It is necessary to induce vomiting, introduce a large amount of fluid into the body and follow a diet with a limited amount of vitamin D3. Further treatment is symptomatic.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.

Translation of the brain instruction

Tags: Supervit