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Pharmacological properties

Vitamin A (retinol acetate) plays a key role in the synthesis of protein enzymes and structural components of tissues, it is necessary for the formation of epithelial cells, bones and the synthesis of rhodopsin, supports the division of immunocomponent cells, the normal synthesis of immunoglobulins and other factors that protect against infections.

Vitamin E (α-tocopherol acetate) is a physiological antioxidant that protects cell membranes from damage, stimulates the synthesis of heme and many proteins.

Vitamin B1(thiamine hydrochloride) - an important coenzyme in the metabolism of carbohydrates, takes part in the functioning of the nervous system.

Vitamin B2(riboflavin) is a part of flavin coenzymes - flavin mononucleotide and flavin adenine dinucleotide, which take part in redox reactions, and is a catalyst for cellular respiration processes.

Vitamin B6(pyridoxine hydrochloride) plays an important role in the metabolism of amino acids, neurotransmitters and hemoglobin.

Vitamin B12 (cyanocobalamin) is a growth factor, necessary for the normal course of blood formation and maturation of red blood cells, takes part in the synthesis of amino acids, nucleic acids and myelin.

Nicotinamide, a component of the cofactor NAD (H) and NADP (H), part of the glucose tolerance factor, takes part in the processes of tissue respiration, carbohydrate and lipid metabolism.

Folic acid is necessary for the normal formation of blood cells; along with vitamin B12 stimulates erythropoiesis, takes part in the synthesis of amino acids, nucleic acids, in the exchange of choline.

Vitamin C (ascorbic acid) takes part in redox processes, it is necessary for the growth and formation of bones, skin, teeth, capillary endothelium and the normal functioning of the nervous and immune systems.

Rutin reduces the permeability and fragility of capillaries, takes part in redox processes, inhibits the action of hyaluronidase.

Calcium D-pantothenate is part of coenzyme A, necessary for the normal functioning of the tricarboxylic acid cycle, ATP synthesis, the production of hormones and antibodies, the synthesis of acetylcholine, the absorption of potassium, glucose, vitamin E from the intestine.

Copper - an essential trace element - takes an active part in the metabolism of iron, the synthesis of hemoglobin, the maturation of reticulocytes, and anabolic processes.

Potassium is involved in electrolyte metabolism, conducting nerve impulses.

Fitin is a complex organic compound of phosphorus containing a mixture of calcium and magnesium salts of inositol phosphoric acids; stimulates blood formation, enhances bone growth and development, improves the function of the nervous system.

Glutamic acid takes part in metabolic processes, helps neutralize and release ammonia, and stimulates the transmission of excitation in the synapses of the central nervous system.

Methionine is an essential amino acid, it is necessary for the growth and nitrogen balance of the body, takes part in the processes of transmethylation and transulfonation, prevents fatty liver cells.

Vitamins and minerals are found in Kvadevit in physiological, balanced doses that meet the needs of the human body.

The pharmacokinetics of the drug has not been studied.

Indications

The drug is indicated as a prophylactic and therapeutic agent:

  • with mental and physical exertion;
  • with hypovitaminosis, an increased need of the body for vitamins and minerals due to unbalanced nutrition, adherence to a special diet, gastrointestinal disorders;
  • during the recovery period after suffering serious illnesses, operations, injuries and stressful situations;
  • to increase the overall resistance of the body and the prevention of infectious diseases during epidemics (such as, for example, flu);
  • to stimulate the healing of wounds, burns;
  • in order to reduce toxicity and reduce the severity of side effects during antibiotic therapy, during and after chemotherapy;
  • in the complex treatment of atherosclerosis, cerebrovascular accident and cardiovascular failure.

Application

The drug is taken orally after a meal.

For preventive purposes, Kvadevit is prescribed for adults and children over the age of 14 years, 1 tablet per day, for elderly people - 1 tablet 2 times a day. The duration of the preventive course is 1-2 months.

For therapeutic purposes, apply 1 tablet 3 times a day. The course of treatment is 3-4 weeks. Repeated courses are carried out after a 3-month break.

During pregnancy and lactation, the drug is used exclusively as directed by a doctor. In the first trimester - no more than 1 tablet per day, in the second and third trimester - no more than 2 tablets per day. During breastfeeding, for prophylactic purposes, take 1 tablet per day, with treatment - 1 tablet 2 times a day.

Contraindications

Hypersensitivity to the components of the drug, severe renal impairment, gout, hyperuricemia, nephrolithiasis, erythremia, erythrocytosis, thromboembolism, active pulmonary tuberculosis, fructose intolerance, thrombophlebitis, hypervitaminosis a and e, iron or copper metabolism dysfunction, thyrotoxicosis chronic, chronic heart failure, a history of sarcoidosis, active peptic ulcer of the stomach and duodenum.

Side effects

In recommended doses, the drug is well tolerated and rarely causes side effects, which are usually associated with individual intolerance to one of the components of the drug.

On the part of the immune system: in patients with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, hyperthermia; bronchospasm in individuals with hypersensitivity to vitamins A, C, group B.

On the part of the skin and subcutaneous tissue: rashes, urticaria, itching, redness of the skin.

From the digestive tract: dyspeptic disorders, nausea, vomiting, diarrhea, epigastric pain, belching, constipation, possibly increased secretion of gastric juice.

From the side of the nervous system: headache, dizziness, increased irritability, drowsiness.

Others: urine is yellow in color, hyperhidrosis, visual impairment.

With prolonged use of the drug in high doses, irritation of the mucous membrane of the digestive tract, arrhythmia, paresthesia, hyperuricemia, transient increase in the activity of AsAT, LDH, alkaline phosphatase, decrease in glucose tolerance, hyperglycemia, impaired renal function, dryness and cracks in the hands and feet, hair loss are possible , seborrheic rashes.

special instructions

When using the drug, it is necessary to observe the dose and duration of the course of administration.

In the absence of a therapeutic effect or the appearance of adverse reactions, you should consult a doctor for advice on the further use of the drug.

It is possible to stain urine in yellow, which is a safe symptom and is explained by the presence of riboflavin in the preparation.

The drug is prescribed with caution in case of severe liver injuries, stomach and duodenal ulcers, patients with nephritis, chronic pancreatitis, cholelithiasis, with decompensation of cardiac activity, coronary heart disease, diabetes mellitus, patients with neoplasms (except in cases accompanied by megaloblastic anemia), and urine.

When using Kvadevit, as well as other multivitamin preparations, a complete protein diet is needed, which contributes to better absorption and metabolism of vitamins, especially water-soluble ones.

Kvadevit is not recommended to be prescribed together with other vitamins and preparations containing trace elements, due to a possible overdose of the latter.

Use during pregnancy and lactation. During pregnancy and lactation, the drug is taken only on the recommendation of a doctor.

The dose of vitamin A should not exceed 5000 IU for pregnant women and women planning a pregnancy.

Retinol should not be taken in high doses (over 10,000 IU) during lactation due to the threat of hypervitaminosis A in infants.

Children. This dosage form is not intended for use in children under the age of 14 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. There is no data on the effect of the drug on the ability to drive a car or work with complex mechanisms.

Interactions

The drug is not recommended to be taken simultaneously with other multivitamins, since an overdose of the latter in the body is possible.

Vitamins A and E mutually reinforce the action and are synergists. Retinol reduces the severity of the anti-inflammatory effect of glucocorticoids. You can not be taken with nitrites and colestyramine at the same time, since they disrupt the absorption of retinol.

Vitamin A cannot be prescribed with retinoids, since their combination is toxic.

Preparations containing iron inhibit the action of vitamin E. Vitamin E cannot be used together with preparations of iron, silver, drugs that have an alkaline environment (sodium bicarbonate, trisamine, etc.), indirect anticoagulants (dicumarin, neodicumarin, etc. ) Alpha-tocopherol acetate enhances the effects of steroidal and non-steroidal anti-inflammatory drugs (sodium diclofenac, ibuprofen, prednisolone, etc.).

Vitamin C enhances the action of sulfonamides (risk of crystalluria), penicillin, increases iron absorption, reduces the effectiveness of heparin and indirect anticoagulants. The absorption of vitamin C is reduced while it is used with oral contraceptives.

Vitamin B6 weakens the effect of levodopa, prevents or reduces the severity of toxic manifestations that are noted with the use of isoniazid and other anti-TB drugs.

Thiamine, affecting the polarization processes in the neuromuscular synapses, can weaken the curariform effect.

PASK, cimetidine, calcium preparations, alcohol reduce the absorption of vitamin B12.

Folic acid reduces plasma concentrations of phenytoin, with other antiepileptic drugs, a mutual decrease in clinical effectiveness is possible.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin).

Tricyclic antidepressants, imipramine and amitriptyline inhibit the metabolism of riboflavin, especially in the tissues of the heart.

Overdose

No cases of overdose of the drug quadvit have been reported. in case of an overdose, allergic reactions (itching, skin hyperemia, skin rashes) and dyspeptic symptoms (nausea, vomiting, diarrhea, epigastric pain), changes in the skin and hair, impaired liver function, headache, drowsiness, lethargy, facial hyperemia can occur irritability.

Treatment: cancel the drug, symptomatic therapy.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.

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