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Pharmacological properties

complex preparation of targeted metabolic action. a rationally selected composition contributes to a more pronounced targeted biological effect of the drug on increasing the resistance of the human body in adverse conditions due to the synergistic regulatory action of the components on the narrow links of cell metabolism, primarily the bioenergetic metabolism, transmethylation and transulfurization reactions.

The drug promotes the assimilation and transformation in tissues into biologically active forms of vitamins, both included in its composition, and entering the body with food.

Metovitan is an effective hepatoprotector, helps normalize intracellular metabolism in all organs, promotes detoxification of lipo- and hydroperoxides, lowers blood cholesterol, increases phospholipids, and as a result increases immunity, mental and physical capacity for work, which generally leads to an increase in the bodys resistance to action adverse environmental factors. The drug also increases appetite and normalizes digestion.

Methionine is an essential amino acid that is part of proteins, plays an important role in the synthesis of a number of biologically important compounds, activates the action of hormones, vitamins and enzymes, and neutralizes toxic products.

Vitamin E has antioxidant properties, is involved in the biosynthesis of heme and proteins, cell proliferation, other major processes of tissue metabolism, and prevents the hemolysis of red blood cells. It is necessary for the development and functioning of connective tissue, as well as for strengthening the walls of blood vessels. Inhibits FLOOR by free radicals. It activates phagocytosis and is used to maintain the correct resistance of red blood cells.

Vitamin B1 normalizes the functional activity of the nervous, cardiovascular and digestive systems.

Vitamin B3 takes part in redox reactions, regulation of biochemical processes in the body by participating in the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Zinc is one of the important trace elements that make up many enzyme systems that regulate the basic metabolic processes, namely, take part in protein synthesis and carbohydrate metabolism.

Pharmacokinetics The substances that make up Metovitan are easily absorbed in the intestines and are quickly metabolized as natural components of living cells. The drug activates protein synthesis, various metabolic reactions: transmethylation, transulfurization, deamination, decarboxylation. With urine excreted in small quantities. The activating effect caused by the introduction of the drug is prolonged, therefore, Metovitan should be taken intermittently, for example, during the week - take daily, next week - a break, etc.

Indications

For prevention and as part of the complex therapy of liver diseases: non-alcoholic and alcoholic steatohepatosis, liver damage due to the use of toxic chemicals (arsenic, chloroform, benzene) and drugs (including antibiotics). in the postoperative period and the recovery period after illness, including intoxication of various origins. in combination therapy for chronic alcoholism. with increased mental and physical stress, especially in adverse environmental conditions. to increase the bodys resistance to infectious diseases, including colds.

Application

The drug is prescribed for therapeutic purposes to adults, 1 capsule 3 times a day.

For prevention in autumn and spring, during an epidemic, the drug is recommended to take 2 capsules 1 time per day.

Capsules should be taken orally after 0.5 hours after meals in courses of 5-10 days with the same intervals.

The duration of admission is determined by the doctor individually and can be from 2 weeks to 2 months.

Contraindications

Hypersensitivity to any of the components of the drug. hepatic encephalopathy, severe hepatic failure, acute viral hepatitis. congenital homocysturia disease, in which there is a violation of homocysteine ​​remethylation to methionine.

Side effects

Adverse reactions can sometimes occur, mainly when used in high doses.

On the part of the immune system: in people with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, hyperthermia, itching, skin rash; rarely - bronchospasm in individuals with hypersensitivity to B vitamins.

On the part of the skin and subcutaneous tissues: rash, urticaria, itching, redness of the skin.

From the gastrointestinal tract: dyspeptic disorders, nausea, vomiting, diarrhea; rarely - possibly increased secretion of gastric juice.

From the nervous system: headache, dizziness, increased arousal, drowsiness.

In the event of any undesirable reaction, it is necessary to consult a doctor about the further use of the drug. After a dose reduction or temporary discontinuation of the drug, adverse reactions disappear within 2-3 days.

special instructions

The appearance of a specific smell of urine is possible, which is not a harmful factor. this is due to an increase in the concentration in the urine of sulfur-containing compounds - methionine metabolism products.

With prolonged use of the drug, it is advisable to periodically monitor the content of homocysteine ​​in the blood.

Use during pregnancy and lactation. During pregnancy and lactation, the drug is taken only on the recommendation of a doctor.

Children. The drug in this dosage form is not intended for use in children.

The ability to influence the reaction rate when driving vehicles or other mechanisms. There were no reports that the drug affects the ability to drive a car or work with other mechanisms.

Interactions

Vitamin e can not be used together with iron, silver preparations, drugs that have an alkaline environment (sodium bicarbonate, trisamine), indirect anticoagulants (dicumarin, neodicumarin). Vitamin E enhances the action of steroidal and non-steroidal anti-inflammatory drugs (sodium diclofenac, ibuprofen, prednisone), reduces the toxic effect of cardiac glycosides (digitoxin, digoxin), vitamins a and d. iron-containing drugs inhibit the effects of vitamin e.

Vitamin B1, influencing the processes of polarization in the area of ​​neuromuscular synapses, can weaken the curariform effect of muscle relaxants.

The drug reduces the severity of the negative effects on the body of toxic drugs, including paracetamol.

Do not use with other multivitamins, since an overdose of the latter is possible.

Overdose

Symptoms: arterial hypotension, tachycardia, disorientation are possible.

Treatment: gastric lavage, the appointment of activated carbon, symptomatic therapy.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.

Tags: Metovitan