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Instruction manual

For medical use of the drug




Active ingredients, retinol (vit a), thiamine (vit b]), riboflavin (vit b2), pyridoxine (vit be), ascorbic acid (vit c), nicotinamide;

1 tablet contains retinol acetate (vitamin A) in terms of 100% substance - 1.72 mg (5000 ME), thiamine hydrochloride (vitamin B [) in terms of 100% substance - 2 mg, riboflavin (vitamin B)2) in terms of 100% substance - 2 mg, pyridoxine hydrochloride (vitamin Bb) in terms of 100% substance - 2 mg, ascorbic acid (vitamin C) in terms of 100% substance - 70 mg, nicotinamide in terms of 100% substance - 15 mg; excipients: wheat flour, starch syrup, sugar, peppermint oil, yellow wax, sunflower oil, talc :.

Dosage form.


Basic physical and chemical properties: dragees from yellow to orange, spherical in shape, with a smooth, uniform in color surface. A specific odor is allowed.

Pharmacotherapeutic group.

Vitamins multivitamin complexes without additives :.

Code ATX A11V A.

Pharmacological properties.

The pharmacological effect of the drug is determined by the properties of vitamins that make up its composition. the drug regulates metabolic processes, normalizes metabolism. Pharmacodine Amica.

Vitamin A (retinol acetate) plays a key role in the synthesis of protein enzymes and structural components of tissues, it is necessary for the formation of epithelial cells, bones and the synthesis of rhodopsin (visual pigment), supports the separation of immunocompetent cells, the synthesis of immunoglobulins and other factors that protect against infections:

Vitamin AT, (thiamine hydrochloride) - a coenzyme in the metabolism of carbohydrates, takes part in the functioning of the nervous system.

Vitamin B2 (riboflavin) is a catalyst for cellular respiration and visual perception.

Vitamin WB (pyridoxine hydrochloride) as a coenzyme takes part in protein metabolism and the synthesis of neurotransmitters.

Vitamin C (ascorbic acid) takes part in the redox processes of the body, the synthesis of hemoglobin, affects the metabolism of amino acids, accelerates the absorption of iron from the gastrointestinal tract, increases the nonspecific resistance of the body, is necessary for the growth and formation of bones, skin, teeth and normal functioning of the nervous and immune systems.

Nicotinamide takes part in the processes of tissue respiration, carbohydrate and lipid metabolism.


After oral administration, the drug is well absorbed from the small intestine into the systemic circulation, penetrates into all organs and tissues.

Clinical characteristics.


  • Prevention and treatment of hypovitaminosis; with prolonged treatment with antibiotics; to enhance the bodys resistance to infectious diseases.


Hypersensitivity to certain components of the drug, severe impaired renal function, gout, hyperuricemia, tendency to thrombosis, thrombosis, thrombophlebitis, thromboembolism, a history of sarcoidosis, nephrolithiasis, fructose intolerance, glucose-galactosyl glucose disease, malabsorption syndrome, hypertension, duodenum in the exacerbation phase (due to a possible increase in the acidity of gastric juice), violated liver dysfunction, active hepatitis, hypertension (severe forms), impaired iron or copper metabolism.

Interaction with other drugs and other types of interactions.

Hexavit is not recommended to be prescribed together with other multivitamins, since an overdose of the latter in the body is possible.

Retinol reduces the anti-inflammatory effect of glucocorticoids. Do not take simultaneously with nitrites and cholestyramine, because they disrupt the absorption of retinol.Vitamin A should not be prescribed with retinoids, since their combination is toxic.

Thiamine hydrochloride, affecting the polarization processes in the area of ​​neuromuscular synapses, can weaken the curariform effect of muscle relaxants.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). Tricyclic antidepressants, imipramine and amitriptyline inhibit the metabolism of riboflavin, especially in the tissues of the heart.

Vitamin Wb weakens the effect of levodopa and enhances the action of diuretics, prevents or reduces toxic effects that occur when taking isoniazid and other anti-TB drugs.

Vitamin C enhances the action and toxicity of sulfonamides (the possibility of crystalluria), penicillin, increases the absorption of iron, the absorption of aluminum (taken into account when treated with antacids that contain aluminum), reduces the effectiveness of heparin and indirect coagulants ;. Large doses of the drug reduce the effectiveness of tricyclic antidepressants, antipsychotics - phenothiazine derivatives, tubular reabsorption of amphetamine, and disrupt kidney excretion of mexiletine.

Ascorbic acid can be taken only 2 hours after injection of deferoxamine. Long-term use of large doses of the drug reduces the effectiveness of disulfiram treatment. Ascorbic acid increases the overall clearance of ethyl alcohol. Ascorbic acid enhances the excretion of oxalates in the urine and increases the risk of crystalluria in the treatment of salicylates.

The absorption of vitamin C is reduced with the simultaneous use with oral contraceptives, the use of fruit or vegetable juices, alkaline drink :.

When using nicotinamide with lovastatin, cases of rhabdomyolysis have been reported.

Features of the application.

When using the drug, it is necessary to adhere to the dosage and duration of the course of administration.

The drug should be used with caution in patients with acute nephritis, urolithiasis, with severe liver damage, with gastrointestinal diseases, a peptic ulcer of the stomach and duodenum in the anamnesis, coronary heart disease, with decompensation of cardiac activity, dystrophic heart diseases, and diseases of organs hematopoiesis, with disorders of iron metabolism (hemosiderosis, hemochromatosis, thalasemia), cholelithiasis, with chronic pancreatitis, allergic diseases , Idiosyncrasies, diabetes, glaucoma, hemorrhage, hypotension moderate. When using the drug, it is necessary to control blood pressure and kidney condition :.

It should be taken into account that the use of ascorbic acid in large doses can change some laboratory parameters (blood glucose, transaminases, uric acid, creatinine). The simultaneous intake of ascorbic acid with alkaline drink reduces its absorption, so you should not drink the product with alkaline mineral water. Do not take medicine with hot drinks (especially coffee), alcohol. It is not recommended to take the drug at the end of the day, since ascorbic acid has a mild stimulating effect. When using the drug, like other multivitamin preparations, a complete protein diet is necessary, which contributes to better absorption and metabolism of vitamins, especially water-soluble ones.

Women who took high doses of retinol (more than 10,000 IU) can be planning a pregnancy no sooner than after 6-12 months, because during this time there is a risk of fetal malfunction due to the high content of vitamin A in the body.

The drug is not recommended to be prescribed together with other medicines that contain vitamins, since an overdose of the latter in the body is possible :.

The drug contains sugar, which should be considered for patients with diabetes. It is possible to stain urine in yellow, which is a completely harmless factor and is explained by the presence of riboflavin in the preparation.

Use during pregnancy or lactation.

Use during pregnancy or lactation is possible only for preventive purposes after consulting a doctor with strict adherence to the recommended doses, taking into account the benefits of benefits for the mother over the potential risk to the fetus / child. to prevent the risk of teratogenic effect in the p-trimesters of pregnancy and during lactation, hexavit can be used only for prophylactic purposes, exclusively for the purpose and under the supervision of a doctor in a dose of not more than 1 tablet per day.

The dose of vitamin A should not exceed 5000 ME for pregnant women and women who are planning a pregnancy.

Do not take large doses of retinol (more than 10,000 IU) for women during lactation due to the threat of hypervitaminosis A.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

There are no data on the effect on the reaction rate when driving vehicles or other mechanisms, but drivers and operators of complex mechanisms should take into account the likelihood of side effects such as dizziness, drowsiness, and visual impairment.

Dosage and administration.

Hexavit taken orally after a meal.


Treatment: 1 tablet 3 times a day.

Prevention of hypovitaminosis: 1 tablet per day.

Grandfather with 14 children

Treatment of hypovitaminosis: 1 tablet per day.

Pregnant women and women during lactation

Prevention of hypovitaminosis: in the second and third trimesters of pregnancy, as well as during lactation, prescribe 1 tablet per day (maximum daily dose). The duration of the preventive course is determined by the doctor individually. Therapeutic doses for pregnant women and mothers who are breastfeeding should not be used.

The drug can be used within 30 days. The course of treatment is repeated 2-3 times a year. The duration of administration and the frequency of treatment courses depends on the specific indications for use, the severity and form of the pathological process, the age of the patient.


For children under 14 years of age, the use of the drug is contraindicated.


Symptoms: dyspeptic symptoms (nausea, vomiting, abdominal pain, belching, constipation, diarrhea), allergic reactions (itching, skin rashes), changes in the skin and hair, impaired liver function, drowsiness, lethargy, irritability, headache, hyperemia of the face. in such cases, the drug should be discontinued.

Treatment: symptomatic therapy, gastric lavage, sorbents.

With prolonged use of vitamin C in large doses, inhibition of the function of the insular apparatus of the pancreas, a change in the renal secretion of ascorbic and uric acids during acetylation of urine with the risk of precipitation of oxalate calculi, is possible.

Adverse Reactions

When using the drug in recommended doses, adverse reactions are very rarely possible:

  • on the part of the immune system, in people with hypersensitivity to the components of the drug, allergic reactions are possible, including anaphylactic shock, Quinckes edema, hyperthermia, rarely - bronchospasm in people with hypersensitivity to vitamins A, C, B vitamins;
  • from the cardiovascular system: arterial hypertension;
  • on the part of the skin and subcutaneous tissues: skin rashes, urticaria, itching, redness of the skin, dry skin;
  • from the gastrointestinal tract: stomach pain, belching, constipation, increased secretion of gastric juice, dyspeptic disorders, nausea, vomiting, diarrhea;
  • from the nervous system: headache, dizziness, irritability, drowsiness, sweating, sleep disturbance; hot flashes accompanied by a feeling of palpitations; fatigue, irritability;
  • on the part of the organs of vision: visual impairment, dryness of the mucous membrane of the eyes;
  • from the side of metabolism: kristashіuria, glucosuria;
  • on the part of the blood system and lymphatic system: blood coagulation disorder, erythrocyte hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency;
  • laboratory data: bleeding disorders, crystalluria, glucosuria;
  • others: urine staining yellow ’is possible.

During prolonged use of high doses, the following adverse reactions may occur:

  • from the side of metabolism: decreased glucose tolerance, hyperglycemia, impaired metabolism of zinc, copper;
  • from the nervous system: paresthesia, convulsions, anorexia;
  • from the cardiovascular system: arrhythmias, arterial hypotension;
  • on the part of the blood system and lymphatic system: erythrocytopenia, neutrophilic leukocytosis;
  • from the gastrointestinal tract: gastrointestinal disturbances, irritation of the gastric mucosa, transient increase in the activity of aspartate aminotransferase (ACT), lactate dehydrogenase (LDH), alkaline phosphatase;
  • on the part of the skin and subcutaneous tissues: hair loss, seborrheic rashes, dryness and cracks in the palms and feet, hyperpigmentation;
  • from the kidneys and urinary tract: impaired renal function, renal failure;
  • on the part of the liver and biliary tract: jaundice, fatty degeneration of the liver;
  • from the side of musculoskeletal and connective tissues: myalgia, myopathy;
  • laboratory data: electrolyte imbalance, hyperuricemia.

Shelf life.

1 year.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.


50 tablets in a container.

50 tablets in a container, 1 container in a pack.

Vacation category.

Over the counter.


Pao "vitamins."

The location of the manufacturer and his address of the location of the activity.

20300, Ukraine, Cherkasy region, Uman, st. Lenin spark, 31.


Pao "vitamins."

Location of the applicant and / or representative of the applicant.

20300, Ukraine, Cherkasy region, U.man, st. Lenin spark, 31.