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Pharmacological properties

Complivit - a multivitamin preparation. the effect of the drug is determined by the properties of water-soluble B vitamins and vitamin C, which are part of it and are components of enzyme systems; actively affect various functions of the body: they regulate energy and metabolic processes in the body, normalize the functioning of organs and systems, accelerate tissue regeneration processes, increase the bodys ability to work under mental and physical stress, and increase the bodys resistance to infectious diseases, adaptation to stress.

Vitamin B1 normalizes the functional activity of the nervous, cardiovascular and digestive systems.

Vitamin B2 plays an important role in protein, fat and carbohydrate metabolism, participates in maintaining normal visual acuity, normalizes skin functions.

Vitamin B6 necessary for the regeneration of the skin and liver cells, restoration of the nervous system, improves fat metabolism in atherosclerosis.

Folic acid, in addition to antianemic effects during pregnancy, protects the fetus from the effects of teratogenic factors, participates in the exchange and synthesis of amino and nucleic acids.

Vitamin PP is a specific antipellagric agent that improves carbohydrate metabolism.

Calcium pantothenate plays an important role in oxidation processes, is involved in carbohydrate and fat metabolism, in the synthesis of acetylcholine, which is involved in the transmission of nerve impulses.

Vitamin B12 affects the normal maturation of all body cells, especially blood and liver cells, has a beneficial effect on the functioning of the nervous system and liver.

Vitamin C plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, normal capillary permeability, the formation of steroid hormones and constituents of connective tissue, and helps increase the bodys resistance to infectious diseases.

Pharmacokinetics The drug is well absorbed in the digestive tract, its metabolic products are excreted from the body mainly with feces and urine.

Indications

Treatment of hypo- and vitamin deficiencies caused by insufficient intake or increased need for vitamins: irregular and uniform nutrition; improving metabolism and general condition of all age groups; period of increased mental and physical stress; pregnancy or lactation; period of active sports; stress chronic diseases; recovery period after serious illnesses, after antibiotic and chemotherapy, before and after surgery; in the complex treatment of patients with atherosclerosis, coronary heart disease and liver diseases.

Application

Complivit is taken orally with food, washed down with enough water. adults and adolescents over the age of 14 are prescribed 1-2 capsules 1 time per day, the course of treatment is 20 days. if necessary, repeat the course after 2 months (after consultation with a doctor).

Contraindications

Increased individual sensitivity to any components of the drug, thromboembolism, tendency to thrombosis, thrombophlebitis, erythremia, erythrocytosis, severe kidney disease, gastric and duodenal ulcers, severe hepatic impairment, active hepatitis, neoplasms (except in cases accompanied by megaloblastic) (severe forms), gout, hyperuricemia, nephrolithiasis, impaired iron and copper metabolism, hypercalcemia.

Side effects

On the part of the immune system: reactions of increasing sensitivity to the components of the drug, including anaphylactic shock, bronchospasm, and angioedema, are possible.

From the side of metabolism and digestion: hypercalcemia.

From the cardiovascular system: AH.

From the hematopoietic system: erythrocyte hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency, impaired blood coagulation.

From the nervous system: headache, dizziness, sleep disturbances, increased irritability, fatigue.

From the side of the organ of vision: visual impairment, dry skin / mucous membrane of the eye.

From the digestive tract: dyspepsia, nausea, vomiting, belching, pain in the stomach, constipation, diarrhea, increased secretion of gastric juice.

On the part of the skin and subcutaneous tissue: rash, urticaria, itching, redness.

From the kidneys and urinary tract: discoloration of urine, hypercalciuria, crystalluria, glucosuria.

General disorders and violations of the conditions of admission: hyperthermia, irritability, hyperhidrosis, hot flashes, which may be accompanied by a feeling of palpitations.

During prolonged use of high doses, the following adverse reactions may occur.

From the side of metabolism and digestion: hyperuricemia, impaired glucose tolerance, hyperglycemia, impaired metabolism of zinc, copper.

From the nervous system: paresthesia, convulsions, anorexia.

From the cardiovascular system: arrhythmias, arterial hypotension.

From the hemopoietic system: erythrocytopenia, neutrophilic leukocytosis.

From the digestive tract: gastrointestinal disturbances.

On the part of the skin and subcutaneous tissue: hair loss, seborrhea, hyperpigmentation.

From the kidneys and urinary tract: renal failure.

From the hepatobiliary system: jaundice, fatty liver.

From the musculoskeletal system: myalgia, myopathy.

Laboratory indicators: a temporary increase in the level of AcAT, alkaline phosphatase, LDH, an increase in the level of uric acid in the blood, a violation of the electrolyte balance.

special instructions

The drug contains lactose, so it should not be used in patients with hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome. it is not recommended to use with other multivitamin complexes in order to avoid overdose and the development of adverse reactions.

It is possible to stain urine in yellow, which is a completely harmless factor and is explained by the presence of riboflavin in the preparation.

The drug should be taken with caution in patients with diabetes mellitus, dystrophic heart diseases, diseases of the blood forming organs, impaired iron metabolism (hemosiderosis, hemochromatosis, thalassemia), gastrointestinal diseases, glaucoma, hemorrhages, moderate hypotension. When using the drug, it is necessary to control blood pressure and the condition of the kidneys. It should be taken into account that the use of ascorbic acid in high doses can change some laboratory parameters (blood glucose, transaminases, uric acid, creatinine). The simultaneous intake of ascorbic acid with alkaline drink reduces its absorption, therefore, the drug should not be washed down with alkaline mineral water. Do not take medicine with hot drinks (especially coffee), alcohol. It is not recommended to take the drug at the end of the day, since ascorbic acid has a mild stimulating effect. Do not exceed recommended dose.

Use during pregnancy and lactation. Take only as directed by your doctor. During pregnancy, the use of excessive doses of ascorbic acid can lead to the development of its deficiency and dependence in the fetus. Ascorbic acid passes into breast milk.

Children. The drug in this dosage form should not be used in children under the age of 14 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. There are no references to the fact that the drug can have a negative effect when driving or working with complex equipment.

Interactions

When short-acting sulfanilamides are used with ascorbic acid, the risk of crystalluria increases. with simultaneous use it enhances the effect of penicillin, increases the absorption of iron, reduces the effectiveness of heparin and indirect anticoagulants, enhances the absorption of aluminum (take into account with simultaneous treatment with antacids containing aluminum). absorption of vitamin C decreases with simultaneous use with oral contraceptives, the use of fruit or vegetable juices, alkaline drink. ascorbic acid can be taken only 2 hours after injection of deferoxamine. prolonged use of high doses of ascorbic acid reduces the effectiveness of disulfiram treatment. high doses of the drug reduce the effectiveness of tricyclic antidepressants, antipsychotics - phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt kidney excretion of mexiletine.

Ascorbic acid increases the overall clearance of ethyl alcohol. Preparations of the quinolone series, calcium chloride, salicylates, tetracyclines, corticosteroids with prolonged use reduce the reserves of ascorbic acid in the body. Ascorbic acid enhances the excretion of oxalates in the urine and increases the risk of crystalluria in the treatment of salicylates. Folic acid reduces plasma concentrations of phenytoin. The simultaneous use with antithrombotic drugs leads to an increased risk of bleeding, with antihypertensive drugs - increased arterial hypotension, with lipid-lowering drugs - increased risk of their toxic effects, with antidiabetic drugs - reduced hypoglycemic effect of the latter, with methyldopa or β-adrenergic blockers - a significant reduction HELL with probenecid - a decrease in the effect of probenecid.

Vitamin B6 weakens the effect of levodopa, prevents the occurrence or reduces the toxic manifestations of isoniazid and other anti-TB drugs.

Ethyl alcohol, PASK, cimetidine, calcium preparations reduce the absorption of vitamin B12. Caution is prescribed for patients with angina pectoris, with unstable angina pectoris and acute myocardial infarction, which receive nitrates, calcium channel antagonists and β-adrenergic blockers. When using nicotinic acid with lovastatin, cases of rhabdomyolysis have been reported.

Thiamine hydrochloride, affecting the polarization processes in the area of ​​neuromuscular synapses, can weaken the curariform effect of muscle relaxants.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). Tricyclic antidepressants, imipramine and amitriptyline inhibit the metabolism of riboflavin, especially in the tissues of the heart.

Overdose

Ascorbic acid is a water-soluble vitamin, its excessive amount is excreted in the urine. however, prolonged use of vitamin C in high doses may inhibit the function of the insular apparatus of the pancreas, which requires monitoring the state of the latter. an overdose can lead to changes in the renal secretion of ascorbic and uric acids during acetylation of urine with the risk of precipitation of oxalate calculi.

In case of an overdose of the drug, dyspeptic symptoms (nausea, vomiting, diarrhea, epigastric pain), allergic reactions (itching, skin rash), changes in the skin and hair, impaired liver function, headache, drowsiness, lethargy, facial flushing, irritability can be observed . In such cases, the drug is stopped. Therapy is symptomatic.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.

Tags: Complivit