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Pharmacological properties

The properties of Aevita are determined by the pharmacological effects of the fat-soluble vitamins a and e, which are part of it. the drug acts on the nuclei of target organ cells and initiates the synthesis of protein enzymes and structural elements of tissues, stimulates regeneration processes, and increases the specific and non-specific resistance of the body. Aevit normalizes metabolism, has an active antioxidant effect, restores capillary circulation, tissue and vascular permeability, and increases tissue resistance to hypoxia.

AEvit is well absorbed in the digestive tract. Further, vitamins A and E are transported to the lymph, then to the blood plasma, where they bind to specific proteins and are transported to organs and tissues. Excess vitamin A is deposited in the liver, mainly in the form of palmitic acid esters. Vitamin A is excreted in the intestines with bile and is involved in enterohepatic circulation. In the liver, it undergoes biotransformation, turning first into active metabolites, and then into inactive metabolic products secreted by the kidneys, intestines and exhaled by the lungs. Vitamin A elimination is slow - in 3 weeks, 34% of the dose taken is excreted from the body. Excess vitamin E is deposited in the tissues, creating a depot in them (especially in the liver), which maintains a normal level of vitamin E in blood plasma. In the body, vitamin E undergoes biotransformation, turning into a series of metabolites with a quinone structure. Vitamin E in an unchanged form is excreted in the bile, in the form of metabolites in the urine.

Indications

It is used for therapeutic purposes in diseases and conditions requiring long-term administration of vitamin A in high doses in combination with vitamin e: atherosclerotic vascular changes, tissue trophism disorder, obliterating endarteritis, psoriasis, lupus erythematosus, optic nerve atrophy, retinitis pigmentosa, in complex cardio therapy -vascular diseases (hypertension with signs of overload of the left ventricle, stable angina pectoris і and іі functional class).

Application

Take orally after meals daily, 1 capsule per day for 30-40 days. a second course should be carried out if necessary after 3-6 months.

Contraindications

Hypersensitivity to the drug, hypervitaminosis a and e, thyrotoxicosis, chronic glomerulonephritis, gallstone disease, decompensated heart failure, a history of sarcoidosis, chronic pancreatitis, severe cardiosclerosis, myocardial infarction.

Side effects

From the nervous system and sensory organs: fatigue, drowsiness, lethargy, irritability, headache, sleep loss.

From the gastrointestinal tract: loss of appetite, nausea, dyspeptic disorders (pain in the epigastric region, diarrhea); very rarely - vomiting.

Allergic reactions, including pruritus, rash; dry, flaky skin; increase in body temperature; hyperemia of the face.

Others: with prolonged use - hair loss, pain in the bones of the lower extremities.

With prolonged use, exacerbation of gallstone disease and chronic pancreatitis is possible. Long-term intake of vitamin A in high doses can cause the development of hypervitaminosis A.

special instructions

The drug is used with caution in patients with an increased risk of thromboembolism, severe atherosclerosis of the coronary arteries, chronic circulatory failure, with acute or chronic nephritis, cholecystitis, and severe damage to the hepatobiliary system.

The drug should not be prescribed simultaneously with other drugs, which include vitamin A and its synthetic analogues, because of the risk of hypervitaminosis A.

Vitamin A tends to accumulate and stay in the body for a long time.Women taking high-dose retinol can plan their pregnancy no earlier than 6–12 months later. This is due to the fact that during this time there is a risk of impaired fetal development under the influence of a high content of vitamin A in the body.

Use during pregnancy and lactation is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Children. The drug is not prescribed for children.

The ability to influence the reaction rate when driving vehicles and working with other mechanisms. There is no data on the effect of the drug on the ability to drive vehicles or work with complex mechanisms.

Interactions

The drug can not be prescribed simultaneously with estrogens, which increase the risk of hypervitaminosis a; nitrites and colestyramine, which interfere with the absorption of vitamin a.

Retinol palmitate reduces the anti-inflammatory effect of glucocorticoids.

The drug can not be used together with other derivatives of vitamin A because of the danger of overdose, the development of hypervitaminosis A.

Vitamin E enhances the effects of steroid drugs and NSAIDs (sodium diclofenac, ibuprofen, prednisone); reduces the toxic effect of cardiac glycosides (digoxin, digitoxin), vitamins A and D.

Overdose

A single dose of the drug in a high dose is accompanied by a sudden increase in CSF pressure (without pathological changes in the cerebrospinal fluid itself), severe headache, drowsiness, and visual impairment (diplopia). in severe cases, convulsive seizures, heart weakness develop. with prolonged use of the drug, chronic hypervitaminosis a may develop, which is manifested by lesions of the nervous system (headache, insomnia, irritability, apathy, paresthesias), general weakness, loss of appetite, fever, changes in the skin (dryness and cracked skin on the palms of the hands) and feet, the appearance of age spots, hair loss, seborrheic rashes), jaundice, changes in blood picture, pain in bones and muscles, gait disorders, enlarged liver and spleen. when used in high doses for a long time, creatinuria, an increase in the concentration of xc, tg, an increase in the activity of creatine kinase, a decrease in the concentration of thyroxine and triiodothyronine in the blood serum, an increase in the content of estrogen and androgen in the urine, a decrease in blood coagulation, and bleeding in the gastrointestinal tract are possible. in case of signs of an overdose, the drug should be discontinued. symptomatic treatment.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° c.

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