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Pharmacological properties

Due to its central role in metabolism, magnesium is an important element for the body. Magnesium is necessary to provide many energy processes in the body, it is involved in the metabolism of proteins, fats, carbohydrates, nucleic acids and in the process of neuromuscular excitation.

Numerous functions of generating or consuming energy (such as chemical reactions, transport of macro- and micronutrients, muscle contraction) depend on magnesium and, if there is a violation of magnesium supply to the body, they can be insufficiently or completely disrupted.

Magnesium activates glucose breakdown enzymes, cellular oxidation enzymes, protein synthesis enzymes, it also plays an important role in myocardial contraction processes; It is a stabilizer of fibrinogen and platelets. Magnesium deficiency is known to be one of the pathogenetic mechanisms in the development of hypertension, vasospasm, neoplastic diseases, and urolithiasis. In stressful situations, an increased amount of free ionized magnesium is excreted, and therefore an additional amount of magnesium contributes to an increase in resistance to stress. Magnesium plays a leading role in the processes of neuromuscular excitation, acting as an antagonist of calcium ions.

The total amount of magnesium in an adults body is about 20-30 g. Of this amount, approximately 50% is in the bones, 45% is in the cells and only 5% of the total can be detected in blood plasma.

The intracellular concentration of magnesium varies from 10 to 60 mmol / L, the normal value of the concentration of magnesium in blood plasma is in the range from 0.7 to 1.1 mmol / L. In blood plasma, approximately ⅔ of magnesium ions are in dissolved form and about 1/3 - binds to proteins.

When used internally, magnesium is absorbed depending on the initial magnesium content in the body. With a deficiency of magnesium in the body, it is absorbed more, and when saturated with magnesium, less. Resorption is accelerated or slowed down in accordance with the needs of the body, which is characteristic of physiologically active substances. With an equilibrium balance of magnesium and preserved kidney function, despite high doses of magnesium, there is no increased accumulation of magnesium in excess of the normal limit.

After absorption in the intestine, magnesium is excreted mainly by the kidneys. Undigested magnesium is excreted along with feces.

Indications

The drug magnesium fortissimum biolectrum is indicated for the treatment and prevention of magnesium deficiency in the body in those cases when it is a cause of disturbances in muscle activity (neuromuscular disorders, cramps), chronic physical and mental fatigue, irritability, myalgia, and intense physical and mental stress during pregnancy.

With hypomagnesemia, which arose as a result of prolonged smoking and alcohol abuse, prolonged use of laxatives, contraceptives, some diuretics or osmotic diuresis in patients with diabetes mellitus with constant hyperglycemia.

Application

Adults and children over the age of 15 are prescribed 1 effervescent tablet 1 time per day.

The tablet must be dissolved in a glass of water, the resulting solution to drink.

The duration of treatment depends on the reasons underlying the deficiency of magnesium in the body, and is determined individually by the doctor.

Contraindications

Hypersensitivity to any component of the drug.

Impaired renal function; conduction disorders in the heart (high grade AV block), which can lead to bradycardia. Hypermagnesemia, hyperkalemia, severe myasthenia gravis, exicosis, chronic urinary tract infections, calcium-magnesium-phosphate-ammonium diathesis.

Side effects

At higher doses, soft stools are possible, which are not dangerous and disappear after a dose reduction.with prolonged use of the drug in high doses, a feeling of fatigue may develop. in this case, the doctor must decide on the feasibility of further intake of magnesium.

special instructions

1 effervescent tablet contains 4.65 mmol (107 mg) of sodium. this should be considered for patients on a low sodium (low sodium) diet.

1 effervescent tablet contains 2.51 mmol (98 mg) of potassium. This should be considered for patients with limited renal function, as well as for patients on a low potassium diet.

Use during pregnancy and lactation. During pregnancy, there is no risk when using the drug. Taking the drug during lactation is recommended after consultation with the doctor and according to his prescription.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect.

Children. The drug is not recommended for use in children under the age of 15 years.

Interactions

Magnesium, which is part of the drug, can interfere with the absorption of iron, sodium fluoride, tetracycline. in such cases, between doses of the magnesium fortissimum biolectrum preparation and iron, sodium fluoride, and tetracycline preparations, it is necessary to observe an interval of 3-4 hours while taking preparations containing aluminum (for example, antacids), aluminum absorption can be increased.

Magnesium preparations enhance the action of antiarrhythmic and antihypertensive drugs, as well as drugs that inhibit the central nervous system; simultaneous administration with amphetamine, ephedrine, quinidine, quinine is not recommended.

Overdose

When taking magnesium salts inside, hypermagnesemia occurs only with renal failure. in such patients, the intake of magnesium salts is contraindicated.

Symptoms of intoxication. High concentrations of magnesium cause relaxation of skeletal muscles (the concentration of magnesium in the blood plasma is 5.5 mmol / l). Higher concentrations of magnesium ions (10–20 mmol / L) prolong the conduction period in the heart, and even higher concentrations lead to cardiac arrest in diastole.

Intoxication treatment. In / in the introduction of calcium instantly leads to the suppression of the described symptoms, since there is an antagonism between these ions.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° c.

Exclusive Distributor: Naturfarm, ul. Lesnaya, 30a, Kiev, Pushcha-Voditsa, 04075; phone: (044) 401-81-03.

Supplier: Alpen Pharma AG (Switzerland).

Tags: Magnesium Carbonate, Magnesium Oxide