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Pharmacological properties

the active ingredient of livolin forte is 35% lecithin containing phospholipids, which are a highly purified fraction of phosphatidylcholine. the determining component of this fraction is dilinoleoylphosphatidylcholine. These phospholipids in their chemical structure are similar to endogenous membrane phospholipids, which surpass them in functional properties due to the high content of polyunsaturated fatty acids, especially linoleic acid. phospholipids are the main structural elements of cell membranes and cell organelles. they take part in the differentiation, division and regeneration of cells.

The functional significance of phospholipids is based on their amphiphilic properties, which make it possible to regulate the permeability of the cell membrane. Phospholipids improve membrane function, in particular ion exchange, intracellular respiration, biological oxidation, affect the binding of internal respiration enzymes in mitochondria, as well as oxidative phosphorylation in cell energy metabolism. Under physiological conditions, the synthesis of phospholipids covers the normal needs of hepatocytes, which contain a sufficient amount of phospholipids. It is known that the structures of cell membranes and enzyme systems in liver diseases undergo pathological changes. The biosynthesis of phospholipids is impaired, and their lack leads to dysfunction of the cell membrane. These processes are especially pronounced in mitochondria, which are approximately 30% composed of phospholipids. In the mitochondria, important metabolic processes occur, among which the most important is oxidative phosphorylation. Due to the lack of phospholipids, lipid metabolism is disrupted, which leads to fatty degeneration of the liver. Due to its pharmacological properties, the drug normalizes these disorders, promotes the regeneration of subcellular and plasma membranes, reactivates broken membrane-bound enzyme systems and receptors, increases the detoxification ability of the liver and thus normalizes its function.

Pharmacokinetics When taken orally, 90% of the drug is absorbed in the small intestine. The main amount is cleaved under the influence of phospholipase-A to 1-acyl-lyso-phosphatidylcholine, 50% of which is immediately re-acylated into polyunsaturated phosphatidylcholine even during absorption in the small intestine. Polyunsaturated phosphatidylcholine enters the bloodstream through the lymphatic tract and then, mainly in combination with HDL, is transported to the liver. The maximum concentration of phosphatidylcholine in blood plasma after 6-24 hours after administration is an average of 20% of the oral dose. The half-life for the choline component is 66 hours, for saturated fatty acids - 32 hours.

In human kinetics studies, 5% of each of the introduced H isotopes3 and C14 stood out with feces.

Indications

Fatty liver degeneration (including liver damage in diabetes mellitus), acute and chronic hepatitis, pre- and postoperative treatment for surgical interventions on the liver and biliary tract, toxic liver damage; gestosis of pregnant women, radiation syndrome.

Application

In adults and adolescents, the dose is 1 capsule 3 times a day with meals, without chewing, with a small amount of water. recommend the use of the drug for at least 3 months.

Contraindications

Hypersensitivity to the components of the drug, intrahepatic cholestasis, children under 12 years old.

Side effects

In isolated cases, discomfort in the epigastric region is possible.

special instructions

The drug can be used during pregnancy according to indications. there are no data on the use during breastfeeding.

Interactions

Not described.

Overdose

There are no reports of cases of drug overdose.

Storage conditions

In a dry, dark place at temperatures up to 25 ° C.

Tags: Livolin forte