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Pharmacological properties

Hepabene is a combined herbal preparation containing the extract of medicinal haze and dry extract of the fruit of milk thistle. The extract of the smoky medicinal contains the fumarin alkaloid, which has a choleretic effect, normalizes the secretion of bile, and reduces the tone of the sphincter of Oddi.

Milk thistle fruit extract contains silymarin, a bioflavonoid that includes the isomers silibinin, silidianin, and silicristine. Silymarin has a hepatoprotective effect in acute and chronic intoxications, exhibits membrane-stabilizing properties and helps restore liver cells.

Pharmacokinetics After oral administration, silymarin is mainly eliminated with bile and is subject to enterohepatic circulation.

Indications

Treatment of patients with biliary dyskinesia (including after cholecystectomy) and with concomitant chronic liver diseases.

Application

Hepabene capsules are taken after meals. the capsule should be swallowed whole, without chewing, and washed down with a sufficient amount of liquid.

Adults are advised to take Hepabene 1 capsule 3 times a day.

For night pain, an additional dose of 1 capsule is recommended before bedtime. If necessary, the daily dose of the drug is increased to a maximum of 6 capsules (2 capsules 3 times a day).

The course of treatment is determined by the doctor individually, depending on the nature and course of the disease.

Contraindications

Hypersensitivity to active substances or other plants from the family Asteraceae or to any of the components of the drug; acute inflammatory diseases of the liver and biliary tract; acute hepatitis and cholangitis; acute poisoning of various etiologies; cholelithiasis; bile duct obstruction.

Side effects

From the digestive system: nausea, vomiting, dyspepsia, heartburn, diarrhea;

from the urinary system: increased urine output;

from the immune system: allergic reactions (including skin rash, itching, shortness of breath);

vascular disorders: hot flashes;

on the part of the skin and subcutaneous tissue: increased alopecia;

others: increased severity of existing vestibular disorders.

special instructions

In elderly patients, dose adjustment is not required.

In view of the possible estrogen-like effect of silymarin at maximum high doses, it should be used with caution in patients with hormonal disorders (endometriosis, uterine fibroids, carcinoma of the breast, ovary and uterus, carcinoma of the prostate gland). In these cases, consultation with a doctor is required.

In the event of jaundice, it is necessary to consult a doctor for correcting therapy.

Use during pregnancy and lactation is not recommended.

Children. There is no clinical experience with the application.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect. Patients with existing vestibular disorders should take the drug with caution when driving vehicles or working with other mechanisms.

Interactions

With the simultaneous administration of drugs containing silymarin, and oral contraceptives or drugs used for estrogen replacement therapy, a decrease in the effectiveness of the latter is possible. the drug can enhance the effects of drugs such as diazepam, alprazolam, ketoconazole, lovastatin, vinblastine, fexofenadine, clopidogrel, warfarin due to inhibition of the cytochrome p450 system.

Overdose

Overdose cases are not noted. with an overdose, diarrhea, abdominal pain are possible. in case of an overdose, stop taking the drug. symptomatic treatment.

Storage conditions

In the original packaging for protection against moisture at a temperature not exceeding 25 ° C.

Medicinal product information for healthcare professionals.

Tags: Hepabene