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Pharmacological properties

the transulose preparation has a laxative effect by two different mechanisms, since it contains two active substances - dehydrogenated micronized lactulose, soft white paraffin and mineral oil.

Lactulose increases hydration and increases intestinal contents due to the osmotic effect. White soft paraffin and mineral oil are a mechanical laxative, as they lubricate and soften the contents of the intestines. The action begins 6-8 hours after oral administration of the drug.

Pharmacokinetics Lactulose is a synthetic disaccharide. It is not absorbed and does not change when passing through the upper part of the digestive tract. In the large intestine, under the influence of local microflora, it is transformed into organic acids (lactic and acetic), which are excreted in the feces. Mineral oil is not absorbed in the digestive tract.

Indications

Symptomatic treatment for constipation.

Application

The doctor sets the dose individually.

The recommended daily dose is 1-3 scoops 1 time per day, in the evening.

The drug should not be taken by patients in a supine position or immediately before bedtime.

The duration of treatment is no more than 8 days.

In case of diarrhea, the dose of the drug should be reduced. If diarrhea continues, treatment with Transulose should be discontinued.

Contraindications

Hypersensitivity to active substances or any excipient. organic inflammatory diseases of the large intestine (ulcerative colitis, Crohns disease); toxic megacolon, gastrointestinal obstruction or partial intestinal obstruction syndrome, perforation or risk of perforation of the digestive organs, abdominal pain of unknown origin. phenylketonuria (since the drug contains aspartame (E951). galactosemia. childhood.

Side effects

Bloating, abdominal pain, diarrhea, electrolyte imbalance due to diarrhea. these symptoms can occur at the beginning of treatment and disappear when selecting an individual dose of the drug.

Rarely - itching, pain in the anal area and a slight decrease in body weight. The use of mineral oils increases the risk of developing anal infiltrate and sometimes causes irritation in the perianal region.

special instructions

If you skip taking the drug, you should not take a double dose to compensate for the missed one. after discontinuation of the drug, withdrawal syndrome does not develop.

It is not recommended to treat constipation for a long time (8 days) without a doctors recommendation. In case of chronic constipation, as well as with constipation that is not associated with lifestyle changes, or accompanied by pain, fever, bloating, the drug should be used after consulting a doctor.

Treatment includes:

  • an increase in the diet of vegetable fiber and drinks;
  • physical activity and normalization of the number of bowel movements;
  • the drug can be prescribed to patients with diabetes mellitus, since glucose is not included in its composition.

Since diarrhea caused by lactulose can lead to an electrolyte imbalance, it is recommended to use this medicine with caution to patients at risk of developing electrolyte imbalances (for example, patients with impaired renal or hepatic function or those undergoing concomitant treatment with diuretics).

Caution should be used in patients with bed rest and in patients with swallowing disorders, since there is a risk of aspiration of mineral oils in the bronchi and the development of fatty pneumonia.

A doctor’s consultation is recommended if there are painful symptoms in the abdomen of uncertain origin before starting treatment.

Patients with lactose intolerance should use the drug with caution.

The drug contains lactose, galactose and a small amount of fructose. Therefore, patients with rare hereditary galactose or fructose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take this drug.

Use during pregnancy and lactation. Pregnancy. The use of the drug during this period is possible only on the recommendation of a doctor. During the intake of mineral oil, the absorption of fat-soluble vitamins (A, D, E, K) in the mothers body may decrease, which is a potential risk of bleeding in the newborn.

Lactulose: although only some clinical data have been published, the very widespread use of lactulose during pregnancy was not dangerous. In studies conducted on animals, no teratogenic effects were detected.

Mineral oil: there are no clinical data or animal studies.

Lactation. Due to its pharmacokinetic properties, the active substances of the drug are not absorbed in the intestine. Breastfeeding is possible when the mother is taking this drug.

Fertility. No effects are expected since the systemic effect of lactulose is negligible.

Children. Not recommended for use in children.

The ability to influence the reaction rate when driving vehicles or working with mechanisms. There is no data.

Interactions

Long-term intake of mineral oil and white soft paraffin can reduce the absorption of fat-soluble vitamins (a, d, e, k).

Overdose

Symptoms: diarrhea.

Treatment: suspend the drug or reduce the dose of the drug. Due to significant fluid loss associated with diarrhea or vomiting, correction of electrolyte imbalance may be required.

Storage conditions

At a temperature not exceeding 30 ° c.

Tags: Transulose