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Pharmacological properties

Enterospazmil - a combined drug that includes the neatropin antispasmodic drug phloroglucinol dihydrate and Simethicone, prevents the accumulation of gases in the intestines.

After oral administration, phloroglucinol is rapidly absorbed and metabolized during the first passage through the liver, excreted in the form of metabolites mainly in the urine. Time to reach Cmax in blood plasma Tmax - 1 h, at a value of Cmax 2.74 mg / ml T½ is 2 hours. Systemic bioavailability after oral administration is 30%. Clinical studies confirm the relaxing effect of the smooth muscles of the digestive tract. Floroglucinol dihydrate slows down the excessive motility of the colon and colon, which typically occurs in response to food intake in patients with functional intestinal disorders.

Simethicone is a non-toxic, inert, silicon-based surfactant that inhibits formation and contributes to the destruction of gas bubbles. Due to a decrease in the surface tension of the liquid, Enterospasmil causes gas bubbles to form in the gastrointestinal tract, which leads to the dispersion and release of the gas physiologically.

Simethicone prevents the formation of image defects that arise due to gas bubbles during ultrasound or x-ray examinations.

It is not absorbed in the body, after passing through the digestive tract it is excreted unchanged.


Spasms of smooth muscles, including those accompanied by pain of varying intensity, and flatulence of various etiologies: bloating in functional gastrointestinal diseases, dyspepsia, aerophagy, remheld syndrome, postoperative period, gastritis, cardio and / or pylorospasm, enteritis, colitis, functional diarrhea, spastic colitis with constipation, irritable bowel syndrome, cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis; diseases of the urinary tract and gynecological diseases accompanied by smooth muscle spasms and flatulence.

As an aid to x-ray, ultrasound and instrumental examination of the abdominal cavity and small pelvis.


The drug is taken before meals, and if necessary, when painful sensations appear, washed down with a small amount of water. the duration of treatment is determined individually and depends on the presence and duration of the symptoms of the disease.

Children aged 6 to 12 years: take 1 capsule 3 times a day.

Adults and children over the age of 12 years: with functional gastrointestinal diseases, with diseases of the biliary tract, with diseases of the urinary tract and gynecological diseases - 2 capsules 3 times a day.

To prepare for x-ray and / or ultrasound, it is recommended to take 1 capsule 2 times a day and 1 capsule in the morning on the day of the study one day before the study.

The maximum daily dose is 6 capsules, which corresponds to 480 mg of phloroglucinol dihydrate and 750 mg of Simethicone.


Hypersensitivity to phloroglucinol dihydrate, Simethicone or other components of the drug. intestinal obstruction, obstructive conditions of the digestive tract.

Side effects

In some cases, the use of the drug may cause skin allergic reactions (skin rashes, itching), bronchospasm.

special instructions

Use during pregnancy and lactation. the drug should not be prescribed in the i trimester of pregnancy. to use the drug in the ii – iii trimester of pregnancy, consult a doctor.

For the period of breastfeeding, the use of the drug should be discontinued.

Children. The drug is used in children over the age of 6 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect.


Avoid the interaction of fluroglucinol with strong analgesics, such as morphine or its derivatives, due to a possible spasmodic effect.


To date, cases of overdose are unknown.

Storage conditions

At a temperature not exceeding 25 ° C. do not freeze.

Tags: Enterospasmil