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- Availability date:2020-07-30
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Phthalyl sulfathiazole (2- (para-phthalylaminobenzenesulfamido) thiazole) is a sulfanilamide preparation that has a bacteriostatic effect, the mechanism of which is due to a violation of the synthesis of microorganisms of their growth factors - folic and dihydrofolic acids. it is slowly absorbed from the digestive tract when ingested, the main amount of the drug is retained in the intestine, where the active (sulfonamide) part of the molecule is gradually cleaved. the thus obtained high concentration of the drug in the intestine, taking into account the specific bacteriostatic activity against the intestinal flora, determines the high efficiency of phthalyl sulfathiazole in intestinal infections. the drug is low toxic.
Acute dysentery, chronic dysentery in the acute phase, colitis, including ulcerative, enterocolitis, gastroenteritis, intestinal surgery (to prevent purulent complications), amoebic dysentery and paratyphoid infection (as an adjuvant).
Inside. in the acute form of dysentery, adults are prescribed on the 1st – 2nd day - 6 g / day (every 4 hours for 1 g), on the 3rd – 4th day - 4 g / day (every 6 hours on 1 g), on the 5-6th day - 3 g / day (every 8 hours for 1 g). the course dose is 25-30 g. 5-6 days after the 1st course of treatment, the 2nd course is carried out: 1-2nd day - 1 g after 4 hours (at night after 8 hours), only 5 g per day; 3-4th day - 1 g after 4 hours (do not prescribe at night), only 3 g per day. total dose for the 2nd course - 21 g; with a mild illness, it can be reduced to 18 g. Higher doses for adults inside: single - 2 g, daily - 7 g. For children under 3 years of age, the drug is prescribed at a rate of 0.2 g / kg per day; the daily dose during the day is divided into 3 equal parts taken during wakefulness. in the specified dose, the drug is taken within 7 days. children older than 3 years (depending on age) are prescribed 0.4-0.75 g per reception 4 times a day.
For other diseases, the drug is prescribed to adults in the first 2-3 days, 1-2 g every 4-6 hours, in the next 2-3 days - in half the dose. Children are prescribed on the 1st day at the rate of 0.1 g / kg per day. The drug is taken in equal doses every 4 hours with a break at night. In the following days, 0.2–0.5 g is prescribed every 6–8 hours.
Hypersensitivity to the drug, bazedova disease, blood diseases, acute hepatitis.
With caution, patients with nephrosis and nephritis are prescribed.
Depending on the nature of the disease, the drug can be used in combination with antibiotics. at the same time as phthalazole-darnitsa, it is advisable to prescribe well-absorbing sulfonamides - sulfadimesin, etazole and other phthalazole-darnitsa incompatible with salicylates, pask, diphenin (increased toxicity of phthalylsulfathiazole), oxacillin (decreased activity of oxacillin), nitrofogeminemia and increased risk of nitrofogeminemia (anhydrofurane) (nitrofogeminemia) drugs of female and male sex hormones (suppression of the function of the sex glands), calcium chloride and vitamin K (decrease in blood coagulation).
In a dry place.