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Pharmacological properties

Pharmacodynamic parameters. Bifidobacteria, a component of normal human intestinal microbiota, are among the first to colonize the digestive tract of a newborn, they are the dominant intestinal bacteria in breast-fed children, and are necessary for the development of a child at an early age.

Protective and therapeutic effect of Bifidobacterium animalis subsp. lactis contained in linex®Baby is carried out in several ways: this strain limits the growth of pathogens in the gastrointestinal tract by preventing their adhesion to the intestinal wall and further colonization, as well as by competitive antagonism of food substrates, the creation of low pH values ​​in the intestinal lumen due to the production of acids, the production of hydrogen peroxide and bacteriocins with antimicrobial properties. In addition, Bifidobacterium animalis subsp. lactis activates the immune response.

Disorder of the physiological balance of intestinal microbiota due to the influence of pathogens of a viral or bacterial nature, digestive tract infections, antibiotic and chemotherapy, delay in the layout of the normal composition of intestinal microbiota during the neonatal period leads to dyspeptic disorders - the occurrence of increased gas formation in the intestines, colic, and also disorders of defecation, and dermatitis.

Due to the systematic use of Bifidobacterium animalis subsp. lactis effectively reduces the severity and frequency of manifestations of gastrointestinal disorders (diarrhea in the first place) resulting from intestinal dysbiosis; conditions are created for normal intestinal activity. Linex® Baby is used to prevent either as part of a comprehensive treatment of atopic dermatitis, or to normalize the activity of the intestinal immune system.

Pharmacokinetic parameters. After administration of Bifidobacterium animalis subsp. lactis cause a local effect in the digestive tract. The study of pharmacokinetic parameters was not carried out, since absorption into the systemic circulation does not occur. The resistance of the strain to the effects of gastric juice and bile ensures high survival of Bifidobacterium animalis subsp. lactis when passing through the upper gastrointestinal tract. Representatives of this strain form a stable adherence to intestinal mucus and, due to peristaltic contractions and the act of defecation, are slowly excreted from the body.

Indications

In children from the 1st day of life and 12 years old:

  • to normalize and maintain the activity and balance of the intestinal microbiota;
  • to prevent and as a support agent in the case of flatulence, diarrhea or other infectious pathology of the digestive tract of a viral or bacterial etiology (including that caused by rotavirus);
  • against the background of antimicrobial therapy.

Application

Children - 1 packet with meals. frequency of admission: at the age of the 1st day of life and 2 years - 1 time per day; at the age of 2-12 years - 1-2 times a day.

The contents of the package are mixed with baby food or liquid (milk, juice, water).

You can not take Linex® Baby with hot drinks.

Linex course® Baby can continue until the corresponding manifestations of the disease disappear.

Contraindications

Hypersensitivity to the active pharmaceutical ingredient or maltodextrin.

Side effects

In rare episodes, hypersensitivity reactions are possible - itching, rashes.

special instructions

In case of fever above 38 ° C, duration of diarrhea for more than 2 days, severe diarrhea with exsicosis and weight loss, mucus or blood in the stool, intense abdominal pain, if the child has a chronic pathology such as cardiovascular disease or diabetes, immunodeficiency conditions (such as HIV infection) before using the drug should consult a doctor for advice.

In children under the age of 6 years, the treatment of diarrhea should be under medical supervision.

In the treatment of diarrhea, adequate correction of the water-electrolyte balance is also necessary.

Due to the lack of relevant studies, there is no information on the effect on the reaction rate when driving vehicles or other mechanisms.

Interactions

Not installed.

Due to the sensitivity of bifidobacteria to antibiotics, taking Linex® Baby should be carried out 3 hours after the application of these funds.

Overdose

Not found.

Storage conditions

At a temperature of ≤25 ° C in the original packaging out of the reach of children.

Tags: Linex Baby