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Pharmacological properties

Secrepat forte is a combined balanced antacid drug to eliminate heartburn and stomach pain. a decrease in the severity of pain and heartburn is provided by the effects of the components that make up the drug.

Calcium carbonate acts within a few minutes after administration, neutralizing hydrochloric acid.

Due to the flotation effect, magnesium trisilicate promotes the formation on the surface of the gastric contents of an antacid film, which covers the wall of the esophagus during reflux. Aluminum salts (dihydroxyaluminium acetate and aluminum hydroxide) in the preparation of Secrepat forte have an acid-neutralizing, enveloping, adsorbing effect, maintaining a pH of about 4. Due to the buffer properties, they neutralize only excess hydrochloric acid, preserve the physiological conditions of digestion and do not lead to secondary hypersecretion of the stomach. The cytoprotective effect of aluminum salts is due to the ability to activate their own protective factors, in particular the synthesis of prostaglandins, which stimulate the secretion of mucus and bicarbonates in the gastric mucosa, which leads to the accumulation of epidermal growth factor in the zone of defect and scarring of ulcers.

In the process of neutralization, carbon dioxide is not formed, flatulence and, as a consequence, secondary hypersecretion does not occur. The drug acts locally. Only a small amount of aluminum compounds is absorbed, slightly more - magnesium compounds, which are rapidly excreted from the body with urine. Due to the neutralization of hydrochloric acid, aluminum and magnesium hydroxides are converted to chlorides and excreted from the body with feces.

Indications

Symptomatic treatment for pain and heartburn in diseases of the digestive tract: peptic ulcer of the stomach and duodenum, gastroesophageal reflux disease, dyspepsia, acute and chronic gastritis with increased or normal acid-forming stomach function. irritation of the gastric mucosa caused by smoking or errors in the diet (drinking alcohol, coffee, sweets, flour products, etc.). for prophylactic purposes - with prolonged use of NSAIDs, corticosteroids and other ulcerogenic drugs.

Application

The drug Secrepat forte is taken orally. tablets slowly dissolve or chew. adults are prescribed 1-2 tablets 4-6 times a day, the last time immediately before bedtime. the drug is recommended to be taken 1-1.5 hours after a meal. the course of treatment is 3-4 weeks. with heartburn or pain, the drug is taken in the same dose, regardless of food intake (on request). to protect the gastric mucosa from the irritating effects of ulcerogenic drugs, take 1-2 tablets of secretat forte 2 hours before they are taken. children aged 10–18 years are prescribed ½ doses for adults. The maximum daily dose for adults is 12 tablets.

Contraindications

Hypersensitivity to the drug, severe renal failure (creatinine clearance 30 ml / min); nephrolithiasis due to the formation of stones containing calcium; Alzheimers disease; hypophosphatemia; constipation, chronic diarrhea, severe abdominal pain of unspecified genesis, hypercalcemia and / or conditions leading to hypercalcemia; patient age up to 10 years.

Side effects

The drug is usually well tolerated by patients. In sekrepat fort, the possible astringent properties of aluminum and calcium are balanced with the laxative properties of magnesium. however, adverse reactions may occur.

From the immune system: hypersensitivity reactions, including rash, itching, urticaria, angioedema and anaphylaxis.

Metabolic disorders.In patients, especially those with impaired renal function, prolonged use in high doses can lead to hypermagnesemia (when using antacids containing magnesium) or hypercalcemia and alkalosis. Hypercalciuria, hyperaluminemia can also be noted.

From the gastrointestinal tract. Nausea, vomiting, stomach discomfort, diarrhea, constipation, stool discoloration may develop.

From the musculoskeletal system and connective tissue. Muscle weakness is possible, with prolonged use - osteomalacia.

Other violations. In patients with renal failure, prolonged use of aluminum and magnesium salts in high doses can lead to the development of encephalopathy, dementia, microcytic anemia or worsen the course of osteomalacia induced by dialysis.

With prolonged use of magnesium trisilicate in high doses, the formation of silicate stones in the kidneys is possible.

In case of revealing any undesirable effects or unusual reactions, a doctor’s consultation regarding the further use of the drug is necessary.

APPROPRIATE SAFETY PRECAUTIONS

Do not exceed recommended doses of the drug. The drug should not be taken simultaneously with a large amount of milk or dairy products.

If the symptoms do not disappear, partially persist or intensify after 10 days of treatment, it is necessary to conduct an examination to find out their nature and revise the treatment regimen. The course of treatment should not exceed 10 days. Patients need to see a doctor in case of weight loss, difficulty swallowing and a constant feeling of discomfort in the abdomen, digestive disorders, which appeared for the first time, changes in the course of existing digestive disorders.

Aluminum hydroxide can lead to constipation, and magnesium trisilicate hydrated can cause intestinal hypokinesia, the use of this drug in high doses can cause or complicate intestinal obstruction and intestinal obstruction, especially in patients with an increased risk of such complications, for example, patients with kidney failure or elderly people age.

Aluminum salts are generally poorly absorbed in the digestive tract, therefore, systemic effects in patients with normal renal function are rare. However, the use of the drug in high doses or long-term administration of the drug, or even the use of the drug in normal doses in patients whose diet is low in phosphorus, can lead to a decrease in the phosphate content in the body, which is accompanied by an increase in bone resorption processes and hypercalciuria with increased risk of osteomalacia (due to the binding of aluminum to phosphate).

In patients with renal failure, elevated plasma concentrations of both aluminum and magnesium may be observed. In such patients, prolonged use of aluminum and magnesium salts in high doses can lead to the development of encephalopathy, dementia, microcytic anemia or worsen the course of osteomalacia induced by dialysis.

Aluminum hydroxide can be dangerous for hemodialysis patients with porphyria.

Calcium and magnesium salts should not be used for hypercalciuria. With caution, Secrepat forte is prescribed for patients with impaired renal function, especially those on dialysis, with metabolic disorders and patients on a low-phosphate diet to reduce the risk of intoxication with aluminum, magnesium and the development of hypophosphatemia. With prolonged use of the drug, it is necessary to control the level of aluminum, magnesium and calcium in the blood plasma. Long-term use of the drug in high doses may increase the risk of kidney stones.

Patients with hereditary diseases accompanied by fructose intolerance, with malabsorption of glucose-galactose or sucrose-isomaltose deficiency should not take the drug because of the sucrose content.

Patients with diabetes should be aware that the composition of the drug includes sucrose.

During pregnancy and breastfeeding. During pregnancy, the use of the drug is possible for the intended purpose and under the supervision of a doctor if the expected benefit to the mother outweighs the potential risk to the fetus. Keep in mind the content of aluminum and magnesium ions that can affect transit in the digestive tract:

  • magnesium salts can cause diarrhea;
  • aluminum salts can cause constipation and worsen the course of constipation, often noted during pregnancy.

The presence of calcium in high doses used for a long time increases the risk of hypercalcemia with calcification of various organs, in particular the kidneys.

Avoid prolonged use and exceeding the doses of this drug.

When using the drug in pregnant women, you should avoid the constant use of milk (1 liter contains up to 1.2 g of elemental calcium), as well as dairy products to prevent excess calcium, which can lead to the so-called milk-alkaline syndrome (Burnett syndrome), which is rare , but a serious illness, and requires medical attention.

If it is necessary to prescribe the drug, breast-feeding should be discontinued for the entire period of its use.

Does not affect the ability to drive vehicles and work with other mechanisms.

Children. Used in children over the age of 10 years.

Interactions

The 2-hour interval between taking secrecat forte and the following drugs should be observed: ethambutol, chloroquine, cyclins, diflunisal, diphosphonates, fexofenadine, sodium fluoride, glucocorticosteroids (described the interaction with prednisolone and dexamethasone), indomethacin, kayexalate, ketoconazole, lansozrazide , phenothiazine antipsychotics, penicillamine, phosphorus (additives), thyroxine.

Secrepat forte reduces the absorption of certain drugs (tetracyclines, fluoroquinolones, isoniazid, naproxen, quinidine, cardiac glycosides (digoxin), histamine receptor blockers, adrenergic blockers, iron preparations).

The drug increases the absorption of levodopa, acetylsalicylic and nalidixic acid.

Thiazide diuretics reduce urinary calcium excretion and increase its level in blood plasma. Due to the increased risk of hypercalcemia with the simultaneous use of thiazide diuretics, it is necessary to regularly monitor the level of calcium in the blood plasma.

In the case of simultaneous use with phosphates, fluorine compounds, levothyroxine and Eltrombopag, a decrease in the absorption of the latter occurs.

The simultaneous use of aluminum hydroxide and citrates can lead to an increase in aluminum levels, especially in patients with renal failure.

Overdose

The drug in high doses, as well as with prolonged use (more than 4 weeks) can cause nausea, vomiting, constipation, diarrhea, loss of appetite. renal failure can also occur, especially in patients with impaired renal function, hypercalcemia, alkalosis, electrolyte disturbances (a decrease in the concentration of phosphates and an increase in the concentration of magnesium and aluminum in the blood plasma), which are most likely with chronic renal failure, muscle weakness. cases of acute overdose and symptoms of acute toxicity in humans have not been noted. if the above symptoms occur, stop taking the drug and rinse the stomach.

Storage conditions

At temperatures up to 25 ° c.

Tags: Secrepat forte