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Composition


active ingredients: 1 g of cream contains Acyclovir 50 mg, hydrocortisone 10 mg;


excipients: propylene glycol, soft white paraffin, mineral oil, cetostearyl alcohol, isopropyl myristate, poloxamer, sodium lauryl sulfate, citric acid monohydrate, sodium hydroxide, concentrated hydrochloric acid, purified water.


DOSAGE FORM


Cream.


BASIC PHYSICAL AND CHEMICAL PROPERTIES:


homogeneous cream of white color in an aluminum tube.


PHARMACOTHERAPEUTIC GROUP


Antiviral agents. ATX code D06B B03.


PHARMACOLOGICAL PROPERTIES


Pharmacodynamics.


Acyclovir is an antiviral drug that is highly active in vitro against herpes simplex virus types I and II. Toxic effects on host cells are minimal. Once in cells infected with the herpes virus, acyclovir is phosphorylated to form the active compound Acyclovir triphosphate. The first stage of this process depends on the presence of virus-encoded thymidine kinase. Acyclovir triphosphate acts as an inhibitor and Substrate for viral DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes.


Hydrocortisone is a weak corticosteroid that exhibits a number of immunomodulatory effects. When applied topically, its main role is to control a variety of inflammatory skin lesions.


Cream with acyclovir and hydrocortisone, which combines the antiviral effect of Acyclovir and the anti-inflammatory effect of hydrocortisone, reduces the progression of herpetic vesicles to the formation of ulcers, and also reduces the healing time of lesions.


The exact mechanism of this is not well understood, but it is believed that it is mediated by the clearance of the virus and a decrease in the local inflammatory response on the lips, which leads to a decrease in the signs and symptoms of recurrent herpes.


Pharmacokinetics.


No clinical pharmacokinetic studies have been conducted for Acyclovir cream


and hydrocortisone.


Indications


Treatment of early signs and symptoms of recurrent herpes on the lips (herpetic vesicles) to reduce the progression of episodes of herpetic vesicles to ulceration and shorten the healing time of lesions in immunocompetent adults and children over 12 years of age.


Contraindications


Hypersensitivity to Acyclovir, valacyclovir, propylene glycol or other components of the cream.


Use for the treatment of skin lesions caused by any virus other than herpes simplex, or for the treatment of fungal, bacterial or parasitic skin infections.


SPECIAL SECURITY MEASURES


The cream should only be used to treat herpes on the lips and face. It is not recommended to apply the cream on the mucous membranes of the oral cavity, eyes and use it for the treatment of genital herpes. Avoid accidental contact of the cream with the eyes.


Patients with particularly severe and recurrent manifestations of herpes labialis need to consult a doctor. Patients with herpes should be warned against contact transmission of the virus to other people, especially in the presence of open lesions (in particular, it is necessary to wash your hands before and after using the cream). It is not recommended for people with immunodeficiency. Such patients need to consult a doctor regarding the treatment of any infection.


INTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS


No interaction was detected.


APPLICATION FEATURES


Use during pregnancy or lactation. Pregnant and breast-feeding women are recommended to use the drug only when the benefit, in the opinion of the doctor, exceeds the risk.


ABILITY TO INFLUENCE THE REACTION RATE WHEN DRIVING VEHICLES OR OTHER MECHANISMS


No data available.


DOSAGE AND ADMINISTRATION


The drug is intended for external use.


Adults and children over 12 years of age should apply the cream 5 times a day at approximately 4-hour intervals, except at night. Treatment should be started as early as possible, preferably immediately after the first symptoms or symptoms appear.


Each time, apply enough cream to cover the affected area, including the outer edges of the lesion, if any.


Treatment lasts at least 5 days. If healing does not occur, you can extend the treatment to 10 days. If the symptoms of the disease do not disappear after 10 days of treatment, the patient should consult a doctor. You should wash your hands before and after using the cream and avoid excessive rubbing or touching the affected areas with a towel to prevent exacerbation or transmission of the infection.

Tags: Zovirax Duo® [Acyclovir, Hydrocortisone]