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Pharmacological properties

natamycin is a broad-spectrum polyene antibiotic that is active against pathogenic fungi, including yeast and especially candida albicans, which are most often the cause of genital tract infection. acts fungicidal, binding sterols of cell membranes, violates their integrity, causing the death of microorganisms.

The drug does not exhibit sensitizing activity. There were no cases of allergy to natamycin during treatment or during its industrial production and no development of resistance to it was noted.

Thanks to the enteric-soluble membrane, the tablet acts only in the intestine.

The drug quickly and effectively acts when infected with vaginal yeast fungi (candidiasis). Vaginal suppositories have a therapeutic effect also in the presence of vaginal discharge, inflammation and itching, including the upper, less accessible sections of the vagina. The drug quickly melts into the vagina, forming a foamy mass, which contributes to a uniform and complete distribution of the active substance over its entire surface.

Pharmacokinetics When taken orally in the form of tablets, natamycin is practically not absorbed in the digestive tract.

Current methods could not detect natamycin, used intravaginally, and its derivatives in the blood and biological fluids of the body, which indicates the absence of a systemic effect of the drug.

Natamycin is active when applied topically and is not absorbed through the skin and membranes of the mucous membranes.


  • Tablets: fungal bowel disease; vaginal suppositories: vaginitis caused by candida albicans; cream: fungal skin lesions caused by candida albicans.


Tablets. for the treatment of intestinal candidiasis, adults are prescribed 1 tablet 4 times a day. usually therapy lasts 1 week.

Children aged 3 years and over are prescribed 1 tablet 2 times a day. Due to the pharmacodynamic and pharmacokinetic properties of natamycin, the same dose is recommended for children of all ages. Typically, the duration of treatment is 1 week.

Suppositories. Used in adult women, 1 suppository for 3-6 days. Suppositories are recommended to be inserted as deep as possible into the vagina (in the supine position) once a day (at night). If it is necessary to conduct treatment for several days, the course of therapy should be completed before the onset of menstruation or treatment should be started after it ends.

The cream is applied to the affected areas of the skin 1-4 times a day daily. The duration of therapy is usually 2-3 weeks.


Hypersensitivity to the components of the drug.

Side effects


From the digestive tract: nausea and diarrhea are possible (which occur in the first days of use and disappear on their own during treatment).

Hypersensitivity reactions are possible.

Suppositories. Rarely (0.01%, 0.1%)

Skin and subcutaneous tissue: hypersensitivity reaction, burning sensation and irritation.


Organ systems Rarely (≥1 / 10,000, 1/1000)
General disorders and reactions at the injection site Hypersensitivity reactions, burning sensation, irritation

Hypersensitivity reactions: some irritation or burning sensation may occur at the site of application. If they continue, this may be due to hypersensitivity to preservatives (parahydroxybenzoates). The presence of methyl parahydroxybenzoate and propyl parahydroxybenzoate in the preparation may cause allergic reactions (possibly delayed).

special instructions

The use of natamycin in the form of tablets may be associated with the development of an acute attack of porphyria, therefore, for patients with this disease, the use of the drug is considered unsafe.

Since the tablet preparation contains lactose, it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The drug contains sucrose, which should be considered for patients with diabetes mellitus. Since sucrose is part of the drug, it should not be used in patients with rare hereditary diseases, such as fructose intolerance or sucrose-isomaltase deficiency.

During menstruation, treatment with Pimafucin® in the form of vaginal suppositories should be interrupted. During drug therapy, there is no need to avoid sexual intercourse.

During pregnancy and breastfeeding. Pimafucin® can be prescribed during pregnancy and lactation.

Children. Natamycin in the form of coated tablets is used in children over the age of 3 years; in the form of a cream - in children of all age groups; in the form of vaginal suppositories - do not use in children.

The ability to influence the reaction rate when driving vehicles and working with other mechanisms. Does not affect.


Not described.


No messages. when using vaginal suppositories, a systemic effect is practically excluded, since the drug is not absorbed through the mucous membrane.

Storage conditions

At a temperature not exceeding 25 ° c.

Tags: Natamycin