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Pharmacological properties

mycogel is an antimycotic and antibacterial drug.

The active substance of the drug - miconazole nitrate - inhibits the biosynthesis of ergosterol and changes the lipid composition of the membrane, causing the death of the fungal cell. A pronounced antifungal effect is manifested in relation to dermatophytes (Microsporum canis, Trichophyton rubrum, Epidermophyton floccosum), fungi of the genera Candida, Cryptococcus and some others, as well as fungi of the genus Aspergillus. It shows antibacterial activity against gram-positive microorganisms (mainly staphylococci) and, to a lesser extent, gram-negative bacteria.

Pharmacokinetics Practically not absorbed through intact skin; the concentration of miconazole in blood plasma with topical application is minimal.

Indications

Lesions of the skin and nails caused by dermatophytes or candida fungi sensitive to miconazole; superinfection caused by gram-positive microorganisms.

Application

For adults and children, mycogel is applied to the affected areas of the skin with a thin layer 2 times a day, without rubbing. if necessary, use an occlusive dressing. the course of treatment depends on the effectiveness of therapy and the results of mycological tests and is 1-6 weeks; the average duration of treatment for candidiasis of the skin is 1-3 weeks, infections caused by dermatophytes - 3-4 weeks, infections with a more protracted course - 5-6 weeks. after the disappearance of the clinical symptoms of the disease, the use of mycogel must be continued for at least another 1 week. in the treatment of onychomycosis, after preliminary detachment of the affected nail plate, the gel is applied in a thin layer on the nail bed 1-2 times a day. therapy is carried out continuously for at least 3 months until the final formation of a new nail.

Contraindications

Hypersensitivity to miconazole nitrate and / or other components of the drug; skin diseases caused by herpes viruses.

Side effects

The drug in most cases is well tolerated. The following side effects are possible:

on the part of the skin and its derivatives: reactions at the site of application, including redness, irritation, burning, rash, itching, dry skin; contact dermatitis;

from the immune system: hypersensitivity reactions, including urticaria, angioedema, anaphylactic reactions.

special instructions

Avoid contact with the eyes and open wounds.

Used with caution in cases of microcirculation disorders, diabetes mellitus.

If the nails are damaged, they should be cut as short as possible.

In case of damage to the feet, it is necessary to carefully process the spaces between the toes, wear loose well-ventilated shoes and change socks daily.

With the development of an allergic reaction, you should stop taking the drug.

During pregnancy and breastfeeding. External use of the drug during pregnancy is possible, but requires special care (after consulting a doctor).

With external use of the drug during lactation, it is recommended to suspend breastfeeding during the treatment period.

Children. The drug can be used in children from birth after consulting a doctor.

There are no reports of the ability to influence the reaction rate when driving vehicles or working with other mechanisms.

Interactions

It is not recommended to use mycogel simultaneously with other ointment forms. it was noted that with systemic use, miconazole inhibits cyp 3a4 / 2c9. due to limited systemic availability in topical application, clinically significant interactions are rare. accordingly, information about a possible increase in the activity of antidiabetic drugs - sulfonylurea and phenytoin derivatives when used simultaneously with miconazole is not clinically significant.

However, patients taking oral anticoagulants such as warfarin should be careful and monitor the prothrombin index.

Overdose

Due to the lack of systemic absorption, overdose cases were not noted. symptoms of overdose may be symptoms of skin irritation, which usually disappear after discontinuation of treatment.

The drug is intended only for application to the skin, and not for oral use. If large quantities of the drug are accidentally swallowed, use the appropriate gastric emptying method.

Storage conditions

In the original packaging at a temperature of 2-8 ° C.

Tags: Miconazole