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diyucha rechovina: L-arginine L-aspartate;


1 ml of roschina mix L-arginine L-aspartate 200 mg;


additional ingredients: sorbitol (E 420), methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), sodium saccharin (E 954), caramel flavor, purified water.


Likarska form. Rozchin oral.


Osnovni fiziko-khimichni vlastosti: zlegka zhovtuvata ridina with a caramel smell.


Pharmacotherapeutic group. Inshi cardiologichni likarski zasobi. Amino acids.


The ATX code is C01E.


Pharmacological authorities.


Pharmacodynamics.


Tivomax® And to repair anti-toxic, cytoprotective, antioxidant, deintoxicacin, membrane-stabilizing diya. The most important role in the processes of neutralizing ammonia is the stimulation of vivedennya yogo z organizmu, posilyu deintoxicatsiynu function of the liver. Repair hepatoprotective diya, positively influencing the process of energozabezpechennya in hepatocytes.


Yak donator to nitrogen oxide Tivomax® And here is the fate of the processes of energozabezpechennya organism, zmenshu activation of the adhesion of leukocytes and platelets to the endothelium sudin, zapobigayuchy utvorennyu I rosvitku atherosclerotic plaques, turn on the process of fibrinogenesis, spermatogenesis.


Likarsky zasib repair pomirnu anabolic diya, stimuli dialynist vilochkovoi zalozi, spriya synthesis of insulin and regulation of glucose in the blood during the first hour of the fizichny navantazhennya, spriya korekcii acid-puddle rivnovagi.


Pharmacokinetics.


I didn't finish the job.


Klinichni characteristics.


Shown.


In complex therapy of ischemic heart disease, atherosclerosis of the cerebral cortex, arterial hypertension, atherosclerosis of peripheral cortex; diabetic angiopathy; treatment of acute cerebral hemorrhage; myocardiopathy, chronic heart failure; hypercholesterolemia; chronic obstructive diseases of the liver, interstitial pneumonia, idiopathic legenevoy hypertension, chronic postembolic legenevoy hypertension, acute chronic hepatitis disease etiology; pechinkovo deficiency, pechinkovo encephalopathy, caused by hyperamonia; hypoxic ta asthenic stani; imunokorekci with a reduced function of the thymus hole.


Protipokazannya.


Giperchutlivist to diyucho rechovini abo to be-like z dopomizhnih rechovin likarsky zasobu. Heavy damage to the functions of nirok.


In return for the best likarsky zasobami that inshi vidi in return.


When zastosuvannya argininu aspartate is necessary to vrahovuvati, sho sumisne zastosuvannya aminofilinu z argininom can suprovodzhuvatisya pydvishchennyamistu insulin in the blood; spironolactone z argininom-pydvishchennyam ryvnya kalyu in the blood.


Especially zastosuvannya.


Oberezhno slid zastosovuvati at porushennyah obminu elektrolitiv, zahvoryuvannyah nirok.


Zastosuvannya likarsky zasobu to the patients, who for 6 months in advance were diagnosed with myocardial infarction is not recommended, oskilki rizik pidvishchennya postinfarction mortality.


When zastosuvannya likarsky zasobu it is necessary to reach the unbalanced regime of sleep, to get rid of alcohol, to get rid of alcohol, to take a psychostimulant. Yaksho na tli priyoma likarsky zasobu zrostayut symptoms asthenii, likuvannya neobhidno vidminiti.


Patsientam zi spadkovoyu intolerant fructose not slid priymati likarsky zasib.


I have a problem with the intolerance of any tsukriv slid proconsultuvatisya z likar, before tim yak priymati tsey likarsky zasib.


Zastosuvannya u period vagitnosti abo goduvannya gruddyu.


Likarsky zasib penetrates through the placenta, so at the period of vagitnosty it is possible to get a til tod, if the korist is made for the mother, the potency of the risik for the fetus is transferred.


Dani shchodo zastosuvannya likarsky zasobu in the period of goduvannya gruddyu vidsutni.


Zdatnist vplivati na shvidkist reaktsii pri keruvannii motor transport abo inshimi mechanizmami.


Don't get involved.


Sposib zastosuvannya ta dozi.


Zastosovuvati vnutrishno pid chasodi. We will grow up with ischemic heart disease, atherosclerosis of the cerebral cortex, atherosclerosis of peripheral vessels, diabetic angiopathy-5 ml (1 g of likarsky zasobu) 3-8 times per dose. With hypercholesterolemia, the stans of the transferred acute cerebral hemorrhage, arterial hypertension – 5 ml 3-6 times per dose. With chronic obstructive diseases, legen, interstitial pneumonia, idiopathic legenevii hypertension, chronic postembolic legenevii hypertension – 5 ml 3-6 times per dose. Gostrii ta chronic hepatitis of the disease etiology, pechinkova deficiency, pechinkova encephalopathy, sprichinena giperamonii-5 ml 3-6 times per dose. With hypoxic and asthenic stans, imunokorekcii, with a reduced function of the forkworm-5 ml 4-8 times per dose. The maximum dobova dose is 8 g. Trivaliste course of likuvannya – 8-15 days; if necessary, the course of likuvannya is repeated.


Diti.


Not zastosovuvati dityam vicom until 18 rokiv.


Peredozuvannya.


Symptoms: reactsii pidvishcheno sensitivity, hypoglycemic stani.


Likuvannya. When the significance of the phenomena is apparent, it is necessary to recall the arrival of the Likarsky zasobu. Shown promivannya shlunka, priyom sorbentiv. The antidote of vidsutny. The therapy is symptomatic.


Poblichni reaktsii.


On the side of the shlunkovo-intestinal tract: rydko-vydchutya slight discomfort in the shlunku I intestines, boredom bezposeredno pislya zastosuvannya likarsky zasobu, yak znikayut samostiyno.


On the side of the immune system: reactions of hypersensitivity, including possible allergic reactions.


Likarsky zasib misti so dopomizhni rechovini, yak methyl parahydroxybenzoate, propyl parahydroxybenzoate, sho mozhe viklikati allergic reactions (mozhlivo, upovilneni), in the surrounding seizures-bronchospasm.


Termin appendages. 1.5 roku.


Termin appendages for the rosecrit of the bottle – 14 dib.


Umovi zberigannya.


Zberigati in original packaging at a temperature of no more than 25 °C. Not frozen.


Zberigati u inaccessible to children of the misci.


Packaging.


On 100 ml abo on 200 ml at the bottle; on 1 bottle with a small spoon abo with a small cup at the pachci.


Category of the vidpusku. Without a prescription.


Virobnik. PrAT "Pharmaceutical firma "Darnitsa".


Mistseznahodzhennya virobnika ta addresses mistsya provadzhennya yogo diyalnosti.


Ukraine, 02093, m. Kiev, vul. Borispilska, 13.


MANUAL


on the medical use of the drug


TIVOMAX® A


(TIVOMAX A)


Composition:


active substance: L-Arginine L-Aspartate;


1 ml of the solution contains L-arginine L-aspartate 200 mg;


excipients: sorbitol (E 420), methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), sodium saccharin (E 954), caramel flavor, purified water.


The dosage form. The solution is oral.


Basic physical and chemical properties: slightly yellowish liquid with a caramel smell.


Pharmacotherapeutic group. Other cardiological medications. Amino acids. The ATX code is C01E.


Pharmacological properties.


Pharmacodynamics.


Tivomax® And it has an antihypoxic, cytoprotective, antioxidant, detoxifying, membrane-stabilizing effect. It plays an important role in the processes of neutralizing ammonia and stimulating its excretion from the body, enhances the detoxification function of the liver. It has a hepatoprotective effect, has a positive effect on the processes of energy supply in hepatocytes.


As a nitric oxide donor, Tivomax® A participates in the processes of energy supply of the body, reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium, preventing the formation and development of atherosclerotic plaques, is involved in the processes of fibrinogenesis, spermatogenesis.


The drug has a moderate anabolic effect, stimulates the activity of the thymus gland, promotes the synthesis of insulin and regulates blood glucose during physical activity, contributes to the correction of acid-base balance.


Pharmacokinetics.


It was not investigated.


Clinical characteristics.


Indications.


In the complex therapy of coronary heart disease, atherosclerosis of the heart and brain vessels, arterial hypertension, peripheral vascular atherosclerosis; diabetic angiopathy; conditions after acute cerebral circulation disorders; myocardiopathy, chronic heart failure; hypercholesterolemia; chronic obstructive pulmonary diseases, interstitial pneumonia, idiopathic pulmonary hypertension, chronic postembolic pulmonary hypertension, acute and chronic hepatitis of various etiologies; liver failure, hepatic encephalopathy caused by hyperammonemia; hypoxic and asthenic conditions; immunocorrection with a decrease in the function of the thymus gland.


Contraindications.


Hypersensitivity to the active substance or to any of the excipients of the drug. Severe renal dysfunction.


Interaction with other drugs and other types of interactions.


When using arginine aspartate, it is necessary to take into account that the combined use of aminophylline with arginine may be accompanied by an increase in the content of insulin in the blood; spironolactone with arginine – an increase in the level of potassium in the blood.

Features of the application.


Caution should be used in cases of electrolyte metabolism disorders, kidney diseases.


The use of the drug in patients who have been diagnosed with a myocardial infarction in the previous 6 months is not recommended, since there is a risk of increased post-infarction mortality.


When using the drug, it is necessary to adhere to a balanced sleep and rest regime, give up alcohol, nicotine and psychostimulants. If the symptoms of asthenia grow against the background of taking the drug, treatment should be canceled.


Patients with hereditary fructose intolerance should not take the drug.


If intolerance to certain sugars is established, it is necessary to consult a doctor before taking this medication.


Use during pregnancy or lactation.


The drug penetrates through the placenta, so during pregnancy it can be used only when the expected benefit to the mother exceeds the potential risk to the fetus.


There are no data on the use of the drug during lactation.


The ability to influence the reaction speed when driving vehicles or other mechanisms.


It does not affect.


Method of administration and dosage.


Apply orally during meals. Adults with coronary heart disease, atherosclerosis of the heart and brain vessels, peripheral vascular atherosclerosis, diabetic angiopathy ‒ 5 ml (1 g of the drug) 3-8 times a day. With hypercholesterolemia, conditions after acute cerebral circulation disorders, arterial hypertension – 5 ml 3-6 times a day. For chronic obstructive pulmonary diseases, interstitial pneumonia, idiopathic pulmonary hypertension, chronic postembolic pulmonary hypertension – 5 ml 3-6 times a day. Acute and chronic hepatitis of various etiologies, hepatic insufficiency, hepatic encephalopathy caused by hyperammonemia – 5 ml 3-6 times a day. In hypoxic and asthenic conditions, immunocorrection, with a decrease in the function of the thymus gland – 5 ml 4-8 times a day. The maximum daily dose is 8 g. The duration of the course of treatment is 8-15 days; if necessary, the course of treatment is repeated.


Children.


Do not use for children under the age of 18.


Overdose.


Symptoms: hypersensitivity reactions, hypoglycemic conditions.


Treatment. In the presence of these phenomena, it is necessary to stop taking the drug. Gastric lavage, the intake of sorbents is indicated. There is no antidote. The therapy is symptomatic.


Adverse reactions.


From the gastrointestinal tract: rarely-a feeling of slight discomfort in the stomach and intestines, nausea immediately after using the drug, which disappear on their own.


From the immune system: hypersensitivity reactions, including possible allergic reactions. The drug contains such excipients as methyl parahydroxybenzoate, propyl parahydroxybenzoate, this can cause allergic reactions (possibly delayed), in some cases – bronchospasm.


Expiration date. 1.5 years.


The shelf life after opening the bottle is 14 days.


Storage conditions.


Store in the original packaging at a temperature not exceeding 25 °C. Do not freeze.


Keep out of the reach of children.

Tags: Tivomax [arginine]