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Pharmacological properties

Neocardil contains standardized extracts of leaves and flowers of hawthorn, ginkgo leaves and pueraria root, the main components of which are flavonoids (quercetin, hyperin, hyperoside, vitexin), isoflavones, organic acids, carotenoids, pectins, triterpene and flavon glycosides, choline. the pharmacological effect of the drug is due to the effects of the complex of active substances that make up its composition.

Hawthorn fruit extract has a mild cardiotonic, antianginal, antioxidant, antiarrhythmic, antiplatelet and antispasmodic effect. It improves blood supply and the functional state of the myocardium, contractile and pumping functions of the heart muscle, increases the sensitivity of the myocardium to cardiac glycosides, reduces high blood pressure and normalizes heart rate.

Due to the content of ginkgo biloba leaf extract, the drug improves cerebral blood flow and the supply of brain tissue with oxygen and glucose. It has antihypoxic and antioxidant effects, affects the rheological properties of blood and microcirculation, prevents platelet aggregation, improves blood circulation in the limbs. It normalizes metabolic processes, has a neuroprotective, antihypoxic and antioxidant effect. The drug improves sensory and cognitive function of the brain, prevents the deterioration of mental activity. Pueraria extract has an anti-atherosclerotic effect, eliminates spasm of coronary and cerebral vessels, reduces blood viscosity, helps prevent vascular thrombosis and diabetic complications.

Indications

Neurocirculatory dystonia, as part of the complex therapy of chronic coronary heart disease (angina pectoris, arrhythmias), ag.

Violation of cerebral circulation and brain function of various origins, which is manifested by a deterioration in memory, attention and mental activity, dizziness, sensation of tinnitus, isolation and anxiety, headache and sleep disturbances.

Disturbances of peripheral blood circulation and blood microcirculation in the extremities, including limb arteriopathy, diabetic angiopathy, Raynauds syndrome.

Sensorineural disorders (dizziness, sensation of tinnitus and ringing, hypoacusia, involuntary macular degeneration, diabetic retinopathy).

Vegetovascular manifestations of menopausal syndrome.

Application

Adults should take neocardil 1 capsule 2 times a day, in the morning and in the evening, or once in the morning the entire daily dose.

The drug can be used regardless of food. Capsules should be swallowed with water. The term of treatment is determined by the doctor. The therapeutic effect is usually observed after 1 month. In the absence of positive changes in clinical symptoms or if it worsens within 6 weeks of treatment, you should consult a doctor. The average duration of treatment is 3 months.

Contraindications

Individual hypersensitivity to the components of the drug. severe arterial hypotension and bradycardia.

Side effects

From the digestive system: digestive disorders, dyspepsia, diarrhea, abdominal pain, nausea, vomiting.

From the immune system: hypersensitivity reactions, including numbness of the tongue, lips and cheeks; swelling of the neck, face, arms and legs; tides; sensation of heat throughout the body; feeling of lack of air; dyspnea; angioedema, urticaria.

On the part of the skin: skin inflammation, redness, swelling, rash, itching, eczema.

From the nervous system: headache, drowsiness, dizziness, weakness, tinnitus, syncope (including vasovagal).

On the part of the cardiovascular system: discomfort in the heart area (sensation of constriction of the chest), cardiac arrhythmias (slowing or acceleration of the heart rhythm), arterial hypotension.

If signs of hypersensitivity appear, interrupt the course of treatment and consult a doctor.

special instructions

Before use, consult a doctor.

It is recommended to carefully observe patients who are simultaneously taking drugs that are metabolized by cytochrome P450 3A4. There is no evidence of abuse of ginkgo biloba (EGb 761). Based on the pharmacological characteristics of the drug, ginkgo biloba (EGb 761) has no potential for abuse.

The drug contains lactose. Patients with rare hereditary disorders of lactase deficiency, galactosemia or glucose-galactose malabsorption syndrome should not use this drug.

Use during pregnancy and lactation. There is no data on the use of the drug during pregnancy and lactation, so Neocardil is not used during these periods.

Children. There is no experience with the use of the drug in children, so Neocardil is not used in pediatric practice.

The ability to influence the reaction rate when driving vehicles or other mechanisms. In rare cases, a temporary worsening of the reaction due to drowsiness is possible.

Interactions

Clinical studies of interactions with ginkgo biloba (egb 761) have demonstrated its ability to potentiate or inhibit cytochrome p450 isoenzymes. midazolam concentration level changed after concomitant use of ginkgo biloba (egb 761), which suggests the presence of interaction through cyp 3a4. therefore, drugs that are mainly metabolized via cyp 3a4 and have a narrow therapeutic index should be used with caution.

Hawthorn preparations enhance the effect of quinidine, procainamide, cardiac glycosides. It is not recommended to use hawthorn preparations simultaneously with alkaloids salts due to the formation of sediment.

The drug potentiates the action of antiarrhythmic drugs, enhances the effects of sleeping pills, sedatives, antihypertensive drugs. Do not use the drug with cisapride.

Overdose

Perhaps the occurrence of bradycardia, requiring discontinuation of the drug.

Storage conditions

In the original packaging, at a temperature not exceeding 25 ° C.

Tags: Neocardil