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Pharmacological properties

Purified preparation from the leaves of May lily of the valley and its varieties. acts similarly to digitoxin and strophanthin; gives a longer effect. the mechanism of action is due to inhibition of na + / k + -phase in the cell membrane. with heart failure increases stroke and minute volume of the heart, improves ventricular emptying, which leads to a decrease in heart size and a decrease in oxygen demand of the myocardium.

Indications

Acute and chronic circulatory failure stage II and III, paroxysmal tachycardia, tachysystolic form of atrial fibrillation.

Application

In / in slowly 0.5-1 ml of 0.06% solution in 20 ml of 40% glucose solution. the highest single dose for adults is 1 ml, daily - 2 ml.

Contraindications

Glycoside intoxication, ventricular tachycardia, degree II and III av blockade, severe bradycardia, hypercalcemia, hypokalemia, isolated mitral stenosis, hypertrophic obstructive cardiomyopathy, carotid sinus syndrome, aortic thoracic aneurysm, wpw myocardial infarction, acute myocardial infarction.

Side effects

Mainly due to its overdose or increased patient sensitivity to cardiac glycosides; rarely - allergic reactions.