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Pharmacological properties

Venitan®, gel, contains β-escin. escin is a natural mixture of triterpene saponins derived from horse chestnut seeds (aesculus hippocastanum l.), which have decongestant, venotonic, and anti-inflammatory activity. In addition, escin acts at the initial stage of the inflammatory process, which is associated with increased membrane and capillary permeability and the production of exudate in adjacent tissues.

Escin has an anti-serotonin and antihistamine effect.

Escin inhibits the activity of prostaglandinsynthetase. This enzyme is necessary for the formation of prostaglandins, which play an important role in the mechanism of inflammation.

Escin prevents the decrease in ATP content in endothelial cells and increases the activity of phospholipase A2, an enzyme that is responsible for the release of precursors of inflammatory mediators.

Escin reduces the activity of lysosomal enzymes that break down proteoglycans in the walls of capillaries. This increases the resistance of capillaries, reduces their permeability, thus reducing the amount of exudate and the formation of edema.

Venitan Forte®. Combined angioprotective agent for external use containing β-escin, an extract from horse chestnut seeds, and heparin, a direct-acting anticoagulant.

Escin is a natural mixture of triterpene saponins, which are obtained from horse chestnut seeds (Aesculus hippocastanum L.), which have decongestant, venotonic, and anti-inflammatory activity. In addition, escin acts at the initial stage of the inflammatory process, which is associated with increased membrane and capillary permeability and the production of exudate in adjacent tissues.

Escin has an anti-serotonin and antihistamine effect.

Escin inhibits the activity of prostaglandinsynthetase. This enzyme is necessary for the formation of prostaglandins, which play an important role in the mechanism of inflammation.

Escin prevents the decrease in ATP content in endothelial cells and increases the activity of phospholipase A2, an enzyme that is responsible for the release of precursors of inflammatory mediators.

Escin reduces the activity of lysosomal enzymes that break down proteoglycans in the walls of capillaries. This increases the resistance of capillaries, reduces their permeability, thereby reducing the amount of exudate and the formation of edema.

Heparin blocks thrombin biosynthesis, prevents the formation of fibrin from fibrinogen, has an antithrombotic, antiexudative and moderate anti-inflammatory effect when applied topically.

The drug helps to improve metabolism at the place of use, accelerates the epithelization of the skin with trophic ulcers of the lower leg, and is used externally as an emollient.

According to WHO recommendations, the level of detected Venitan Forte gel effectiveness can be classified as type Ib (level A).

Pharmacokinetics Venitan Forte®. Due to the limited degree of absorption of the medicinal substances that make up the gel, they do not have a systemic effect.

Indications

Venitan®. phlebeurysm; swelling of the legs and pain associated with venous insufficiency; post-traumatic hematomas and hematomas after iv injections and infusions.

Venitan Forte®. Symptomatic treatment for venous diseases such as superficial thrombosis, thrombophlebitis, phlebitis after iv injection and infusion, post-thrombotic syndrome, varicose veins in the legs, trophic ulcers of the leg.

Applied externally for closed injuries, such as hematomas, injuries from shock.

Used for the prevention and treatment of scars on the skin (postoperative and other origin).

Application

Apply a thin layer of cream / gel on the damaged area of ​​the skin and around it 2-3 times a day. do not rub.

The lower extremities are massaged in the direction from bottom to top. With trophic ulcers of the lower leg, gel only lubricates the edges of the ulcer, where blood circulation is impaired. You should not immediately apply all the necessary amount of gel, it is applied gradually, in small portions. With inflammatory diseases of the veins, the gel is not rubbed.

Cautions. With varicose veins on the legs, the simultaneous use of an elastic bandage or elastic stockings is recommended.

The duration of treatment depends on the severity of the therapeutic effect. If there is no improvement after 14 days of therapy, you should consult a doctor.

Venitan Forte®. Therapy can be continued for up to 8 weeks or until symptoms are less severe.

Contraindications

Venitan®. hypersensitivity to the components of the drug, skin damage (e.g. burns, eczema, open wounds).

Venitan Forte®. Hypersensitivity to the components of the drug; trophic bleeding leg ulcers; open and / or infected wounds; hemorrhagic diathesis; purpura; thrombocytopenia; hemophilia; tendency to bleeding; skin lesions (burns, eczema).

Side effects

Hypersensitivity reactions are possible, including dermatitis, including allergic, skin irritation and swelling, skin rashes, urticaria, pruritus, erythema, skin burning, bronchospasm. angioedema, hemorrhage, the appearance of small pustules, vesicles or blisters that quickly pass after drug withdrawal are possible. when applied to large areas of the skin, systemic adverse reactions may develop. in the event of such reactions, it is necessary to stop using the drug and consult a doctor.

special instructions

Do not apply gel on inflamed skin, open wounds and mucous membranes. Do not rub during application. if skin inflammation, thrombophlebitis, severe pain, sudden swelling of one or both legs, heart or kidney failure occur, consult a doctor immediately. with the sudden appearance of severe symptoms of venous insufficiency (edema, discoloration of the skin, a feeling of tension and pain), especially on one limb, venous thrombosis of the lower extremities is not excluded.

The use of the gel for varicose veins does not replace other preventive or therapeutic measures (for example, wearing supportive elastic stockings, dousing with cold water).

Avoid contact with the eyes and mucous membranes. Wash hands thoroughly after each gel application.

Venitan®. The gel contains methyl parahydroxybenzoate (E218), which can cause an allergic reaction (including delayed), and in exceptional cases - bronchospasm, and propylene glycol, which can cause skin irritation.

Venitan Forte®. The gel contains sodium methylparaben (E219), which can cause an allergic reaction (including delayed), and in exceptional cases - bronchospasm, and propylene glycol (E1520), which can cause skin irritation.

Use during pregnancy or lactation. Due to lack of data, the gel should not be used during pregnancy or lactation.

Children. The experience of using the drug in children (under 18 years old) is not enough, therefore it is not recommended to use it in patients of this age category.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Does not affect.

Interactions

Unknown. it is not recommended to use the gel on one skin area together with other topical agents, for example, with preparations containing tetracycline, hydrocortisone, salicylic acid, and anticoagulants. the use of heparin can help prolong the prothrombin time in patients taking oral anticoagulants.

Digitalis, tetracyclines, nicotine, antihistamines weaken the effectiveness of the gel.

Overdose

There are no reports of overdose. due to accidental oral administration of the gel, a child may experience nausea or vomiting. in this case, it is necessary to rinse the stomach, and if necessary, prescribe symptomatic therapy. the effect of heparin can be neutralized with protamine sulfate.

Storage conditions

At a temperature not exceeding 25 ° c.

Tags: Venitan® [Heparin, escin]