$14.40
In stock
Guaranteed refund or reship if you haven't received your order
Secure and encrypted payment processing
We ship to over 40 countries including the USA, UK, Europe, Australia and Japan

Composition:

active ingredients:


100 g of the preparation contains: horse chestnut seed extract dry standardized (Hippocastani seminis extractum siccum normatum) (5-7: 1) (extractant: ethanol 60% (V/V))- 4.725 G, thiamine hydrochloride - 0.5 g;


excipients:

ethanol 96%; purified water; lactose, monohydrate; colloidal anhydrous silicon dioxide.


Dosage form

Oral Drops, solution.


Basic physical and chemical properties:

clear or slightly cloudy liquid from yellow to reddish-brown in color with a characteristic smell. Sediment may form during storage.


Pharmacotherapeutic group

Capillary stabilizing agents. PBX code C05C X.


Pharmacological properties

Pharmacodynamics


Angioprotective, capillary-stabilizing, decongestant, anti-inflammatory agent. The mechanism of action of escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes, which reduces the breakdown of mucopolysaccharides and improves trophic processes in the walls of venous vessels and surrounding connective tissue. The drug reduces pathologically increased vascular-tissue permeability, preventing transcapillary filtration of low-molecular proteins, electrolytes and water into the intercellular space, increases the tone of the venous Wall, eliminates venous congestion (especially in the lower extremities), reduces peripheral edema, reduces the feeling of heaviness in the legs, fatigue, tension, itching, pain.


Pharmacokinetics


When taken orally, escin is rapidly absorbed, mainly from the duodenum. It is subject to a pronounced effect of the first passage through the liver. In tissue fluid and blood plasma, escin binds to proteins (approximately 84 %) and cholesterol. It is metabolized in the liver. It is excreted in the urine and bile in the form of metabolites.


Thiamine hydrochloride in the body is converted to active thiamine diphosphate, participates in carbohydrate and energy metabolism, and is a coenzyme of many enzyme reactions.


Clinical characteristics

Indications.


Chronic venous insufficiency:


- edema;


- cramps of the calf muscles;


- itching, as well as pain and heaviness in the legs;


- varicose veins.


Post-thrombotic syndrome.


Trophic changes in the veins of the lower extremities, such as ulcers of the lower leg.


Hemorrhoids.


Prevention and treatment of post-traumatic and postoperative edema and hematomas.


Contraindications.


Hypersensitivity to the components of the drug. Kidney failure, allergic diseases.


Special security measures


If you experience unusual symptoms or pain in your legs, you should stop using the drug and consult a doctor.


It is necessary to adhere to non-invasive methods of treatment prescribed by the doctor (applying compresses, wearing supportive elastic stockings, dousing with cold water).


When using the drug, renal function should be monitored.


Interactions with other drugs and other types of interactions.


The drug may enhance the effect of antithrombotic agents. Cephalosporin antibiotics increase the concentration of free escin in the blood and the risk of side effects. Concomitant use of the drug with aminoglycoside antibiotics should be avoided due to the increased toxic effect of aminoglycosides on the kidneys.


Thiosemicarbazone and 5-fluorouranil, as well as simultaneous infusion of solutions containing sulfites, inhibit thiamine activity.


Application features.


The use of thiamine in high doses may distort the results when determining theophylline in blood serum by spectrophotometric method and urobilinogen using Ehrlich reagent.


This medicine contains lactose. In this regard, if you have an established intolerance to certain sugars, consult your doctor before taking this medicine.


This medicine contains 116.9 mg of 96% ethanol (alcohol) in 15 drops (1 dose) of the drug.


Harmful to patients with alcoholism. Caution should be exercised when used in patients with liver diseases and patients with epilepsy.


Use during pregnancy or lactation.


The drug is not recommended for use during pregnancy or lactation due to insufficient data on the safety of its use in this category of patients.


Ability to influence the reaction rate when driving vehicles or other mechanisms.


It doesn't affect you.


Dosage and administration.


It is recommended to take 12-15 drops 3 times a day before meals, with a small amount of liquid. The course of treatment is from 2 weeks to 2-3 months.


Due to the possible presence of sediment of plant origin, it is recommended to shake the drug before use.


Children.Do not use in children.


Overdose.


No overdose cases have been reported. Possible increase in side effects. Symptoms of poisoning observed after taking a large amount of horse chestnut seed extract: a feeling of anxiety, severe diarrhea, vomiting, mydriasis, drowsiness, delirium, possible death as a result of respiratory paralysis after 24-48 hours.


Treatment: symptomatic. If a large amount of horse chestnut seed extract has been taken and there is no vomiting, gastric lavage is recommended (for example,


0.02% solution of potassium permanganate), taking activated carbon.


Adverse reactions.


From the cardiovascular system: tachycardia, rapid heartbeat, hypotension.


Nervous system disorders: headache, dizziness.


From the digestive tract: dyspeptic phenomena, epigastric pain, nausea, diarrhea, vomiting.


Immune system disorders:hypersensitivity reactions, including urticaria, rash, itching, heat sensation, angioedema, shock.


In the case of high doses of the drug, nephrotoxic reactions and thrombosis are possible.


Expiration date. 2 years.


Storage conditions.


Store in the original packaging at a temperature not exceeding 25 °C.


Do not freeze.


Keep out of reach of children.

Tags: Thiamine Hydrochloride, Horse Chestnut Fruit Extract