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Composition:


active ingredients: 1 g contains: β-escin, in terms of 100% Substance - 10 mg, sodium heparin, in terms of heparin with an activity of 133 IU/mg – 0.75 mg (100 IU), epicuron 130 g, in terms of dry matter-10 mg;


excipients: isopropyl alcohol, methylparaben (methyl parahydroxybenzoate) (E 218),


propylparaben (propyl parahydroxybenzoate) (E 216), carbomer, Glycerin, 15% ammonia solution, lavender oil, purified water.


Dosage form. Gel.


Basic physical and chemical properties: gel of yellowish color, uniform consistency, with a specific smell.


Pharmacotherapeutic group.


Remedies used for varicose veins. Heparins or heparinoids for topical use. Heparin, combinations.


ATX code C05B A53.


Pharmacological properties.


Pharmacodynamics.


The drug has anti-inflammatory, decongestant and analgesic effects, improves microcirculation and tissue trophism.


Heparin is an acidic mucopolysaccharide with a relative molecular weight of approximately 16,000 Daltons. It belongs to direct-acting anticoagulants. Inhibits blood clotting by inactivating clotting factors (V, VII, IX factors and Hageman factor) and blocking thrombin biosynthesis. The drug reduces platelet aggregation, suppresses the activity of hyaluronidase, activates the process of fibrinolysis.


b-escin is an amorphous water-soluble mixture of triterpene saponin isomers obtained from horse chestnut seeds, Aesculus hippocastanum L. Angioprotective, capillary-stabilizing, decongestant, anti-inflammatory agent. The mechanism of action of b-escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes that break down proteoglycans and enhance the biosynthesis of pain and inflammatory mediators. The drug reduces the permeability and fragility of capillaries, preventing transcapillary filtration of low-molecular proteins, electrolytes and water into the intercellular space; accelerates the resorption of hematomas and reduces lymphostasis, improves venous-lymphatic circulation and increases the tone of the venous wall, which prevents venous congestion and thrombosis in varicose nodes (especially in the lower extremities), reduces peripheral edema, a feeling of heaviness, fatigue, tension and pain in the problem area.


Pharmacokinetics.


Not studied.


Clinical characteristics.


Indications.


Local treatment of acute and chronic venous insufficiency: varicose veins, superficial phlebitis and thrombophlebitis, hematomas and edema after bruises and sprains.


Contraindications.


Hypersensitivity to the components of the drug. Trophic leg ulcers, bleeding, open and/or infected wounds, hemorrhagic diathesis, Purpura, thrombocytopenia, hemophilia, tendency to bleed. Children's age.


Special security measures.


Prevent the drug from getting on the mucous membranes to avoid a burning sensation.


Interactions with other drugs and other types of interactions.


The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and nonsteroidal anti-inflammatory drugs. Ergot purpurea alkaloids, thyroxine, tetracycline, antihistamines, and nicotine reduce the effect of heparin.


Application features.


Use during pregnancy or lactation.


During pregnancy or lactation, the drug can only be used for a short time, as prescribed by a doctor and subject to reasonable indications, if the expected benefit to the mother exceeds the potential risk to the fetus or child.


Ability to influence the reaction rate when driving vehicles or other mechanisms.


It doesn't affect you.


Dosage and administration.


Apply externally to adults.


The gel is applied in a thin layer on swollen and painful areas 2-3 times a day. The course of treatment is 14 days.


Children.


The safety and efficacy of the drug in children have not been studied.


Overdose.


No symptoms of overdose were detected.


Adverse reactions.


It is usually well tolerated.

Possible phenomena of local intolerance in the form of minor itching, redness, burning, skin rashes, contact dermatitis, urticaria, angioedema, hemorrhages.

When applying the gel to large areas of the skin, systemic adverse reactions are possible.

The use of the drug may cause allergic reactions (possibly delayed) due to the presence of excipients in the composition, such as methyl parahydroxybenzoate (E 218) and propyl parahydroxybenzoate (E 216).

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