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ESCUVEN gel 1%

Instruction manual

For medical use of the drug

Escuven®

Structure:

Active substance: aescin;

1 g of gel contains amorphous β-escine 10 mg;

excipients: carbomer, propylene glycol, triethanolamine, methyl paraben (E 218), ethanol 96%, purified water.

Dosage form.

Gel 1%.

Basic physical and chemical properties: colorless or with a yellowish tint, slightly opalescent, transparent uniform gel.

Pharmacotherapeutic group.

Angioprotectors. capillary stabilizing agents.

Code ATX С05С Х03.

Pharmacological properties.

Pharmacodynamics

Escin is a natural mixture of triterpene saponins obtained from horse chestnut seeds (Aesculus hippocastanum L.), which have decongestant, venotonic, and anti-inflammatory activity. In addition, escin acts at the initial stage of the inflammatory process associated with increased membrane and capillary permeability and the production of exudate in adjacent tissues.

Escin reveals anti-serotonin and antihistamine effects.

Escin inhibits the activity of prostaglandin synthetase. This enzyme is necessary for the formation of prostaglandins, which play an important role in the mechanism of inflammation.

Escin prevents the decrease in ATP content in endothelial cells and increases the activity of phospholipase A2, an enzyme responsible for the release of precursors of inflammatory mediators.

Escin reduces the activity of lysosomal enzymes that break down proteoglycans that are contained in the walls of capillaries. This increases the resistance of capillaries, reduces their permeability, thereby reducing the amount of exudate and the formation of edema.

Pharmacokinetics

Not studied.

Clinical characteristics.

Indications.

Varicose veins, leg edema and pain associated with venous insufficiency, post-traumatic hematomas and hematomas after injections and infusions.

Contraindications

Hypersensitivity to the components of the drug, skin damage (eg, burns, eczema, open wounds).

Interaction with other drugs and other types of interactions.

Unknown It is not recommended to use the gel in one area of ​​the skin together with other topical agents.

Features of the application.

Do not apply the gel to inflamed skin, open wounds and mucous membranes. Do not rub during application. if skin inflammation, thrombophlebitis, severe pain, sudden swelling of one or both legs, heart or kidney failure occurs, consult a doctor immediately. with the sudden appearance of severe symptoms of venous insufficiency (edema, discoloration of the skin, a feeling of tension and pain), especially on one limb, it is necessary to exclude venous thrombosis of the lower extremities.

The use of a gel for varicose veins does not replace other preventive or therapeutic measures (for example, wearing supportive elastic stockings, dousing with cold water).

Avoid contact with eyes and mucous membranes. Wash hands thoroughly after each gel application.

The gel contains methyl paraben (E 218), which can cause an allergic reaction (including delayed), and in exceptional cases, bronchospasm, and propylene glycol (E 1520), which can cause skin irritation.

Use during pregnancy or lactation.

Due to the lack of relevant data, Esquen® Gel should not be used during pregnancy and lactation.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Dosage and administration.

Apply the gel in a thin layer on the damaged area of ​​the skin and around it 2-3 times a day. should not be rubbed.

With varicose veins, the simultaneous use of an elastic bandage or elastic stockings is recommended.

The duration of treatment depends on the severity of the therapeutic effect. If after 14 days of therapy there is no improvement, you should consult a doctor.

Children.

The experience of using the drug in children is not enough, so it is not recommended to use it for patients of this age category.

Overdose.

No data on overdose.

Adverse Reactions

Hypersensitivity reactions are possible, including dermatitis, including allergic, skin rash, itching, erythema, burning sensation of the skin, bronchospasm. in the event of such reactions, it is necessary to stop using the drug and consult a doctor.

Shelf life.

3 years.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 ° c.

Keep out of the reach of children.

Packaging.

30 g or 50 g in tubes.

Vacation category.

Over the counter.

Manufacturer / Applicant.

LLC Ternopharm.

The location of the manufacturer and the address of the place of business.

LLC Ternopharm.

Ukraine, 46010, Ternopol, st. Factory, 4.

Tel./fax: (0352) 521–444, http://www.ternopharm.com.ua

Tags: Escin