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Pharmacological properties

gyno-tardiferon is a complex drug of prolonged action iron. the drug makes up for the deficiency of iron and folic acid in the body. folic acid contributes to the normal course of pregnancy, prevents the development of spontaneous abortion, is necessary for erythropoiesis and the synthesis of nucleic acids. folic acid deficiency can cause abnormal development of the spinal cord of the fetus. high safety of the drug is due to the presence of mucoproteoses in its composition.

Mucoproteosis is a natural mucopolysaccharide that protects the mucous membrane of the digestive tract from the irritating (irritating) effect of iron ions, and contributes to the delayed release of iron for 5-6 hours, which significantly increases the tolerance of the drug. Ascorbic acid, which has an antioxidant effect, increases the bioavailability of iron and promotes its absorption.

Pharmacokinetics The drug is absorbed in the duodenum and proximal small intestine. WITHmax iron in blood plasma is reached after about 7 hours and remains elevated for 24 hours after taking the drug.


Prevention and treatment of folic and iron deficiency anemia, including during pregnancy when it is impossible to receive an adequate amount of iron with food.


Inside, with a glass of water, before eating.

Adults and children over the age of 7 years: prevention of iron deficiency anemia - 1 tablet per day on an empty stomach.

Treatment for iron deficiency anemia: children over the age of 7 years - 1 tablet (in the morning), adults - 1-2 tablets per day (morning and evening).

The duration of treatment is set individually, depending on the severity of the anemia. It is recommended to continue therapy for 1-3 months (at a dose of 1 tablet in the morning before breakfast) after normalizing hemoglobin levels.


Hypersensitivity to active or other components of the drug. excess iron (hemosiderosis, hemochromatosis), other types of anemia that are not associated with iron deficiency (hemolytic anemia, aplastic anemia, siderochrestic anemia, iron-refractory anemia; lead poisoning anemia, thalassemia, etc.), esophageal stenosis and / or other obstructive gastrointestinal tract diseases; intestinal diverticulum, intestinal obstruction, regular blood transfusion, the simultaneous use of parenteral forms of iron; children under 7 years old.

Side effects

From the gastrointestinal tract: epigastric pain, abdominal pain, nausea, vomiting, stool staining black, diarrhea or constipation, flatulence, darkening of the teeth.

In people with hypersensitivity, allergic reactions of varying severity may occur (skin rash, urticaria, skin hyperemia, itching, anaphylaxis, bronchospasm, hyperthermia).

Others: hot flashes, general weakness.

Prolonged unreasonable use can lead to constipation and hemosiderosis.

special instructions

It should be borne in mind that iron deficiency anemia associated with inflammatory syndromes is resistant to treatment with iron preparations.

It is necessary to establish the etiology of anemia.

Since the product contains sucrose, it is contraindicated in case of fructose intolerance, glucose / galactose malabsorption syndrome or sucrose-isomaltase deficiency.

Castor oil, which is part of the drug, can cause disturbances in the stomach, as well as diarrhea.

When using the drug, the stool color may turn black, which may interfere with the diagnosis of chronic gastrointestinal bleeding. A test for occult blood in the stool can be false positive.

Eggs and milk, black tea, coffee, bread, raw cereals, dairy products inhibit the absorption of iron.Oral iron preparations should not be taken within 1–2 hours after eating the above foods. Do not take simultaneously with other medicines containing iron. It is used with caution in patients with leukemia, chronic liver and kidney diseases, inflammatory gastrointestinal diseases, gastric and duodenal ulcers, intestinal diseases (enteritis, ulcerative colitis, Crohns disease). Possible exacerbation of rheumatoid arthritis. To prevent constipation, the drug is washed down with a sufficient amount of liquid.

Systematic monitoring of serum iron and hemoglobin is required.

If necessary, approximately every 4 weeks, the following parameters are evaluated to determine the degree of iron deficiency, the response to treatment and the need to continue therapy: hemoglobin, red blood cell count, average red blood cell volume (MCV), average erythrocyte hemoglobin content (MCH), reticulocyte count, plasma iron level, transferrin. Determination of ferritin in blood plasma allows you to assess the level of accumulated iron; an indicator of plasma ferritin of 15 μg / l means the absence of iron stores in the body.

With prolonged use, it is necessary to control the level of vitamin B12.

The drug contains sucrose, which should be considered when used in patients with diabetes mellitus.

Children. Do not use in children under the age of 7 years.

During pregnancy and breastfeeding. Animal studies did not reveal malformations in the offspring of mice and rats who received iron preparations during pregnancy at a dose 1100 times higher than the therapeutic for humans.

Adequate studies in humans have not been carried out, however, when analyzing bibliographic data, no data on malformations in children of women who took iron supplements during pregnancy were revealed.

Iron is excreted in breast milk in an insignificant amount (about 0.25 mg / day).

During pregnancy and lactation, Gyno-Tardyferon should be taken only after consulting a doctor.

The ability to influence the reaction rate when driving vehicles and working with other mechanisms. Not installed.


With the simultaneous use of iron salts, the absorption of tetracycline, dna gyrase inhibitors (e.g. ciprofloxacin, levofloxacin, norfloxacin, ofloxacin), diphosphonate, penicillamine, levodopa, carbidopa and methyldopa, penicillin, sulfasalazine is reduced. iron salts reduce the absorption of thyroxine, zinc. iron absorption decreases with simultaneous administration with colestyramine, antacids (containing aluminum, magnesium, calcium, bismuth), as well as nutritional supplements containing calcium and magnesium. Vitamin C and Citric Acid promote iron absorption. with the simultaneous use of iron salts with NSAIDs, the irritating effect of iron on the gastrointestinal mucosa may increase. absorption of iron can slow down with simultaneous iv administration of chloramphenicol. Tardiferon should not be taken within 2-3 hours after the application of one of the above drugs. if possible, it is necessary to monitor the effectiveness of the simultaneous use of drugs using medical or laboratory diagnostic methods. antibiotics of the tetracycline group, as well as penicillin, form complex compounds with iron sulfate that reduce the absorption of iron and antibiotics. glucocorticoids can stimulate erythropoiesis. the simultaneous use of vitamin e can reduce the pharmacological effect of iron in the body of the child. simultaneous use of iron salts and allopurinol should be avoided.

Folic acid absorption is reduced while taking it with analgesics, anticonvulsants, antacids, colestyramine, sulfonamides, antibiotics, cytostatics (methotrexate), trimethoprim. With simultaneous use with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced. With the simultaneous use of folic acid reduces the effects of primidone, PASK, sulfasalazine, hormonal oral contraceptives, chloramphenicol, phenytoin, increasing its metabolism.


Subject to the recommended doses of gyno-tardiferon, the risk of excessive cumulation of iron is low. if the recommended doses are exceeded, overdose may occur.

Symptoms An acute overdose of iron can be manifested by nausea and vomiting, in severe cases, it can lead to the development of collapse and death. A lethal dose of elemental iron is considered to be 180-300 mg / kg body weight. However, for some patients, a dose of elemental iron of 30 mg / kg may be toxic.

Symptoms of acute iron poisoning can occur within 10-60 minutes or after a few hours. Possible abdominal pain, pain in the epigastric region, nausea, diarrhea with green stools and subsequently tarry, melena, vomiting with or without blood impurities, drowsiness, weakness, pallor of the skin, cold clammy sweat, acrocyanosis, cyanosis, filamentous pulse , lethargy, decreased blood pressure, palpitations, fatigue, shock and coma, confusion, symptoms of hyperventilation, hyperthermia, paresthesia, necrosis of the gastrointestinal mucosa, convulsions.

After about 4-6 hours, a period of imaginary well-being usually sets in. Later, after 12–48 hours, severe shock may develop, accompanied by Cheyne – Stokes breathing, oliguria, toxic liver failure, and coagulopathy.

In connection with the possible toxic effects of an overdose, the patient must immediately receive medical attention. Slow release of iron can slow down its absorption and thereby lengthen the period to assist. If more tablets are accidentally taken, the patient should consume raw eggs and milk, which will lead to the formation of insoluble iron compounds in the digestive tract and will contribute to its elimination from the body. Taken tablets can be removed from the stomach, causing the patient to vomit.

Specific therapy. Vomit must be checked for the presence of Gyno-Tardiferon tablets. With an insufficient number of tablets, gastric lavage should be done with 0.9% sodium chloride solution or 1% aqueous sodium carbonate solution and a laxative should be used. It is necessary to conduct an x-ray examination of the abdominal organs to determine the number of remaining tablets. If the pill removal methods used do not give the desired result, surgery may be necessary.

The best method for assessing the severity of a condition is to determine the iron content in blood plasma and the total iron binding capacity of blood plasma. If the level of iron in the blood plasma exceeds the total iron binding capacity, there is a likelihood of systemic poisoning.

The use of deferoxamine may be necessary. Chelation with deferoxamine should be given if:

  • a potentially lethal dose (180-300 mg / kg and above) was taken;
  • the concentration of iron in blood plasma is 400-500 mg / dl;
  • the concentration of iron in the blood plasma exceeds OZHSS and / or if the patient has severe symptoms of iron intoxication - coma, shock.

In acute poisoning, 5–10 g of the drug is used inside to bind iron that is not absorbed in the digestive tract (the contents of 10–20 ampoules are dissolved in drinking water). To eliminate the absorbed iron, deferoxamine is administered IM in 1-2 g every 3-12 hours.In severe cases, accompanied by the development of shock, intravenous drip of 1 g of the drug and symptomatic therapy are used.

In young children, the risk of acute iron intoxication is particularly high; life-threatening intoxication is possible when taking 1 g of iron sulfate.

If necessary, treat shock and acidosis.

For oliguria / anuria, peritoneal dialysis or hemodialysis is used.

Storage conditions

At a temperature not exceeding 25 ° C.

Tags: Iron, Folic Acid