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Injection solution in a pre-filled Aranesp syringe is indicated for:

  • Treating symptomatic anemia associated with chronic renal failure (CRF) in adults and children over 11 years of age.
  • Treating symptomatic anemia in adult cancer patients with non-myeloid malignancies who are receiving chemotherapy.

Structure

Active ingredient: Darbepoetin Alfa;

Each prefilled syringe contains Darbepoetin Alfa - 30 μg in 0.3 ml (100 μg / ml).

Excipients: sodium chloride, sodium dihydrogen phosphate monohydrate, sodium phosphate anhydrous, polysorbate 80, water for injection.

Contraindications

Hypersensitivity to darbepoetin alfa, r-HuEPO or to any of the excipients.

Arterial hypertension, which is not amenable to adequate drug control.

Mode of application

Treatment takes place only under the supervision of a doctor with experience in treating the above indications.

Aranesp is supplied ready to use in pre-filled syringes. Instructions for use, handling and disposal are provided in the section.

Application features

Pregnant women

Not assigned.

Children

Aranesp can be prescribed to children from 11 years old.

Drivers

Does not affect.

Overdose

Even at very high serum levels, no symptoms of overdose were observed.

In case of polycythemia Aranesp should be temporarily discontinued. In the presence of clinical indications, phlebotomy can be performed.

Side effects

Severe allergic reactions have been reported, including anaphylactic reactions, angioedema, allergic bronchospasm, skin rash and urticaria, which have been associated with Darbepoetin Alfa.

Interaction

The clinical results obtained so far do not indicate any interaction of Aranesp with other substances. However, there is a potential for interaction with drugs that bind to a high degree to red blood cells, for example, cyclosporin, tacrolimus. If darbepoetin alfa is used simultaneously with any of these drugs, you should monitor the levels of these drugs in the blood and adjust the dose with an increase in hemoglobin concentration.

Storage conditions

Store in the refrigerator (2 ° C - 8 ° C). Do not freeze.

Store in the original packaging to protect from light.

Keep out of the reach of children.

Shelf life is 2 years.

Tags: Aranesp®