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Aminosteril N-Hepa infusion solution is used for parenteral administration of amino acids in severe hepatic impairment (liver failure) with / without impaired brain function (encephalopathy), for the treatment of hepatic coma.

Structure

active substances: 1 liter of solution contains:

  • L-isoleucine - 10.4 g / l.
  • L-leucine - 13.09 g / l.
  • L-lysine monoacetate - 9.71 g / l.
  • (L-lysine) - 6.88 g / l.
  • L-methionine - 1.1 g / l.
  • N-acetyl-L-cysteine ​​- 0.7 g / l.
  • (L-cysteine) - 0.52 g / l.
  • L-phenylalanine - 0.88 g / l.
  • L-threonine - 4.4 g / l.
  • L-tryptophan - 0.7 g / l.
  • L-valine - 10.08 g / l.
  • L-arginine - 10.72 g / l.
  • L-histidine - 2.80 g / l.
  • Aminoacetic acid - 5.82 g / l.
  • L-alanine - 4.64 g / l.
  • L-Proline - 5.73 g / l.
  • L-serine - 2.24 g / l.
  • Glacial acetic acid - 4.42 g / l.

Excipients: water for injection.

  • The total amino acid content is 80 g / l.
  • The total nitrogen content is 12.9 g / l.

Contraindications

  • Disruption of amino acid metabolism.
  • Overhydration.
  • Hyponatremia.
  • Hypokalemia.
  • Renal failure.
  • Severe heart failure.

Mode of application

The drug is used only for infusion.

Enter 1 - 1.25 ml per 1 kg of body weight per hour, which is 0.08 - 0.1 g of amino acids per 1 kg of body weight per hour.

Maximum rate of administration: 1.25 ml per 1 kg of body weight per hour, which is 0.1 g of amino acids per 1 kg of body weight per hour.

The maximum daily dose of 1.5 g of amino acids per 1 kg of body weight, equal to 18.75 ml per 1 kg of body weight or 1300 ml per 70 kg of body weight.

Aminosteril N-Hepa is used as long as there remains a need for parenteral nutrition and treatment.

Application features

Pregnant women

During pregnancy and lactation, the drug can be used only when the expected benefit to the mother outweighs the potential risk to the fetus or child.

Children

There are no data on the use of the drug in children, therefore it is not recommended to prescribe it to this age category of patients.

Drivers

During treatment, care must be taken when driving vehicles and working with mechanisms.

Overdose

Very rapid infusion into peripheral veins can cause vein irritation (ensure proper osmolarity). Very fast infusion can cause vomiting. In these cases, the infusion should be stopped immediately. Continued infusion at the correct rate is possible.

There is no data on the toxic effects of amino acids for parenteral nutrition. Since amino acids are physiological components, their toxicity cannot be predicted.

Side effects

Intravenous administration of the drug can lead to overproduction of hydrochloric acid and the development of peptic ulcer, exacerbation of erosive and ulcerative lesions of the gastrointestinal tract, exacerbation of peptic ulcer of the stomach and duodenum.

Allergic reactions to the protein components of the drug (hyperemia, itching) are possible.

Interaction

Amino acid solutions are not recommended as a basis for the introduction of other drugs. This can lead to various physicochemical reactions and the formation of toxic products. Due to the high risk of microbial contamination, the amino acid solution should not be mixed with other drugs. If it is necessary to add carbohydrates, fat emulsions, electrolytes, vitamins, microelements for complete parenteral nutrition, sterility, mixing quality and compatibility should be carefully monitored. Aminosteril N-Hep should not be stored after adding other components.

Storage conditions

Store in a dark place at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life is 3 years.

Tags: Parenteral amino acids