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Gecoven infusion solution is indicated for hypovolemia caused by acute blood loss, in cases where the use of crystalloid alone is considered insufficient.

Structure

Active substances: hydroxyethyl starch 130 / 0.4; sodium chloride;

100 ml of the solution contains: hydroxyethyl starch 130 / 0.4 (average molecular weight 130,000, degree of molar substitution 0.4) in terms of dry substance 6.0 g, sodium chloride 0.9 g;

Excipient: water for injection.

Contraindications

Sepsis, severe liver disease; known increased individual sensitivity to hydroxyethyl starch; clinical diseases where volume overload is a potential problem, especially in the case of pulmonary edema and congestive heart failure; dehydration; existing violations of coagulation and blood coagulation; intracranial bleeding; renal failure or renal replacement therapy; severe hypernatremia or severe hyperchloremia.

It is contraindicated in patients with burns, with transplanted organs and critically ill patients because of the risk of kidney damage and death.

Mode of application

For intravenous administration only.

The daily dose and rate of infusion depend on the amount of blood loss, maintenance or restoration of hemodynamics, and hemodilution (dilution effect). Gecoven can be re-entered within a few days.

The first 10–20 ml of the drug should be administered slowly. The patient should be closely monitored due to possible anaphylactic / anaphylactoid reactions.

Application features

Pregnant women

Gecoven can be used during pregnancy only in cases where the expected benefits of treatment outweigh the possible risk to the fetus.

Children

The use of HES for adolescents from 12 years of age is confirmed by the data of relevant controlled studies of the drug in adults.

Drivers

Gecoven does not affect the reaction rate when driving or working with other mechanisms.

Overdose

As with the introduction of other plasma-replacing solutions, an overdose of Hekoven can overload the circulatory system (for example, pulmonary edema). In this case, the infusion should be stopped immediately and, if necessary, a diuretic should be administered.

Side effects

  • On the part of the blood and lymphatic system: at high doses, with the introduction of hydroxyethyl starch due to the dilution effect, clotting disorders that are dose-dependent can be observed.
  • On the part of the immune system: drugs containing hydroxyethyl starch (HES) can cause anaphylactic / anaphylactoid reactions (hypersensitivity, mild flu-like symptoms, bradycardia, tachycardia, bronchospasm, non-cardiac pulmonary edema). If hypersensitivity reactions occur, the drug should be discontinued immediately and appropriate medical and supportive measures taken until the symptoms are resolved.
  • On the part of the skin and subcutaneous tissue: prolonged administration of high doses of hydroxyethyl starch can cause itching, which is a known side effect of HES.

Interaction

Cases of Hekovens interaction with other drugs are unknown.

During administration of the drug, serum amylase levels may temporarily increase, which may affect the diagnosis of pancreatitis.

At high doses, the effects of dilution can lead to a decrease in the level of coagulation factors and other plasma proteins and a decrease in hematocrit.

Storage conditions

Store at a temperature not exceeding 25 ° C out of the reach of children.

During storage, do not allow freezing of the drug.

Shelf life is 3 years.

Tags: Hydroxyethyl Starch, Sodium Chloride