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STRUCTURE


active ingredient: glucose;


1 ml of glucose monohydrate 50 mg (based on 100% substance) excipients: water for injection.


DOSAGE FORM


Solution for infusions.


BASIC PHYSICAL AND CHEMICAL PROPERTIES:


colorless or slightly yellowish transparent liquid.


PHARMACOLOGICAL GROUP


Blood substitutes and perfusion solutions. ATX code V05SH01.


PHARMACOLOGICAL PROPERTIES


Pharmacological properties


A 5% glucose solution is isotonic in the blood plasma and, when administered intravenously, replenishes the volume of circulating blood, when it is lost, it is a source of nutrient material, and also contributes to the elimination of poison from the body. Glucose provides a substrate for replenishing energy consumption. With intravenous injections, it activates metabolic processes, improves the antitoxic function of the liver, increases the contractile activity of the myocardium, dilates blood vessels, and increases diuresis.


Pharmacokinetics.


After administration, it is rapidly distributed in the tissues of the body. It is excreted by the kidneys.


INDICATIONS


Hyper-and isotonic dehydration;

in children, to prevent violations of the water-electrolyte balance during surgical interventions

, intoxication;

hypoglycemia

as a solvent of other compatible drug solutions.

CONTRAINDICATIONS


5% glucose solution is contraindicated in patients with:


hyperglycemia;

hypersensitivity to glucose.

The drug should not be administered simultaneously with blood preparations.


INTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS


When used concomitantly with thiazide diuretics and furosemide, their ability to affect serum glucose levels should be taken into account. Insulin promotes the entry of glucose into the peripheral tissues. Glucose solution reduces the toxic effect of pyrazinamide on the liver. The introduction of a large volume of glucose solution contributes to the development of hypokalemia, which increases the toxicity of simultaneously used digitalis preparations. Glucose solution is incompatible with aminophiline, soluble barbiturates, hydrocortisone, kanamycin, soluble sulfonamides, cyanocobalamin.


APPLICATION FEATURES


The drug should be used very carefully in patients with intracranial and intracranial hemorrhages.


With prolonged use of the drug, it is necessary to control the level of sugar in the blood.


In order to prevent the occurrence of hypoosmolarity of the plasma, a glucose solution of 5% can be combined with the introduction of an isotonic solution of sodium chloride.


When large doses are administered, if necessary, insulin is prescribed under the skin at the rate of 1 UNIT per 4-5 g of glucose.


The contents of the bottle can only be used for one patient. After breaking the tightness of the bottle or container, the unused part of the contents of the bottle or container should be discarded.


USE DURING PREGNANCY OR LACTATION


The drug can be used according to the indications.


ABILITY TO INFLUENCE THE REACTION SPEED WHEN DRIVING VEHICLES OR OTHER MECHANISMS


Data are not available due to the exclusive use of the drug in a hospital setting.


METHOD OF ADMINISTRATION AND DOSAGE


The drug is used intravenously by drip. The dose for adults is up to 1500 ml per day. The maximum daily dose for adults is 2000 ml. If necessary, the maximum rate of administration for adults is 150 drops per minute (500 ml / h).


CHILDREN


The dose for children depends on the age, body weight, condition of the patient and laboratory parameters.


OVERDOSE


Increased manifestations of adverse reactions.


Possible development of hyperglycemia and hypotonic hyperhydration. In the case of an overdose of the drug, symptomatic treatment and administration of conventional insulin preparations are prescribed.


ADVERSE REACTIONS


Violation of the electrolyte balance and general reactions of the body that occur during massive infusions


hypokalemia

hypophosphatemia;

hypomagnesemia;

hyponatremia

hypervolemia;

hyperglycemia;

allergic reactions (hyperthermia, skin rash, angioedema, shock).

From the gastrointestinal tract:


very rarely - nausea of central origin.

In case of adverse reactions, the administration of the solution should be stopped, the patient's condition should be evaluated and help should be provided.


EXPIRATION DATE


3 years.


STORAGE CONDITIONS


Keep out of the reach of children at a temperature not exceeding 25 ° C. Store in the original packaging.


INCOMPATIBILITY


Glucose solution is incompatible with aminophiline, soluble barbiturates, erythromycin, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, cyanocobalamin.


Do not use in the same system at the same time or before or after blood transfusion due to the possibility of pseudoagglutination.

Tags: Glucose