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Braxon injection solution is indicated for severe infectious diseases caused by microorganisms that are sensitive to the drug:

  • infectious diseases of the central nervous system, including meningitis, septicemia and sepsis of newborns;
  • infectious diseases of the abdominal cavity, including peritonitis,
  • complicated and recurrent urinary tract infections such as pyelonephritis and cystitis
  • infectious diseases of the lower respiratory tract, including pneumonia, bronchopneumonia and acute bronchitis, lung abscess;
  • diseases of the skin, bones and soft tissues, including burns.

Structure

Active substance: tobramycin;

1 ml of tobramycin (in the form of sulfate) - 40 mg;

Excipients: sodium edetate, sodium sulfite anhydrous, water for injection.

Contraindications

Hypersensitivity to tobramycin or other aminoglycoside antibiotics.

Neuritis of the auditory nerve, severe chronic renal failure.

Mode of application

The drug is used intramuscularly (i / m) or intravenously (i / v) drip. For IM use, the appropriate dose is administered directly from the ampoule.

For iv administration, the solution is diluted in 100-200 ml of 0.9% sodium chloride solution or 5% glucose solution, administered for 20-60 minutes.

Application features

Pregnant women

It should be prescribed to pregnant women only in cases where the potential benefit significantly exceeds the potential risk.

Children

Apply from the first days of life.

Drivers

The drug is used in a hospital setting.

Overdose

Symptoms: toxic reactions (hearing loss, ataxia, dizziness, urination disorder, thirst, loss of appetite, nausea, vomiting, tinnitus or a feeling of stuffy ears, nephronecrosis - increased urea concentration, hypercreatininemia, proteinuria, oliguria), respiratory muscles paralysis.

Treatment of patients with normal renal function is carried out by fluid infusion and forced diuresis; patients with impaired renal function - hemodialysis or peritoneal dialysis. In case of neuromuscular blockade - anticholinesterase drugs, calcium salts during respiratory arrest - mechanical ventilation, other symptomatic and supportive therapy.

Side effects

  • From the digestive system: nausea, vomiting, diarrhea, impaired liver function (increased activity of hepatic transaminases, lactate dehydrogenase, hyperbilirubinemia).
  • From the hemopoietic organs: anemia, leukopenia, granulocytopenia, thrombocytopenia, leukocytosis.
  • From the side of the nervous system: headache, neurotoxic effect (nervous tic, paresthesia, epileptic seizures); neuromuscular blockade (difficulty breathing, drowsiness, weakness).
  • From the sensory organs: ototoxicity (partial or complete bilateral deafness, ringing, hum or a feeling of stuffiness in the ears), vestibular and labyrinth disorders (impaired coordination, dizziness, nausea, vomiting, imbalance).
  • From the urinary system: nephrotoxicity (oliguria, cylindruria, proteinuria, a significant increase or decrease in the frequency of urination, polyuria, the appearance of signs of renal failure - increased concentrations of creatinine and urea nitrogen, thirst, decreased appetite, nausea, vomiting).
  • Allergic reactions: itching, flushing of the skin, rash, fever, angioedema, eosinophilia.

Interaction

Tobramycin enhances the action of non-depolarizing muscle relaxants.

Reduces the effect of anti-myasthenic drugs.

Aminoglycosides, cephalosporins, vancomycin, polymyxin, diuretics increase the risk of oto- and nephrotoxicity.

Beta-lactam antibiotics weaken the effect.

Intravenous administration of indomethacin reduces the renal clearance of tobramycin,increasing the concentration in the blood and increases the half-life (T 1/2) (may require correction of the dosage regimen).

Methoxyflurane increases the risk of adverse reactions.

Medicines for inhalation general anesthesia (halogen-containing carbohydrates), narcotic analgesics, transfusion of large volumes of blood with citrate preservatives as anticoagulants, drugs that block neuromuscular transmission, increase neuromuscular blockade.

Storage conditions

Store at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life is 2 years.

Tags: Tobramycin