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Pharmacological properties

Pharmacodynamic parameters. the active pharmaceutical ingredients of the combination drug Tergynan have a multifaceted local therapeutic effect in the inflammatory process in the vaginal mucosa of various etiologies, maintaining its integrity and physiological range of pH values ​​of the vaginal environment.

The aminoglycoside antibiotic neomycin binds to the 30S subunit of the bacterial ribosome, as a result of which the bacterium cannot synthesize proteins that are vital for its growth. Neomycin also inhibits bacterial DNA polymerase. Neomycin is active against pyogenic vaginal microflora. Also sensitive to nystatin are Brahamella catarrhalis and hemophilus bacillus, acinetobacteria, corynebacteria, pathogens of listeriosis, methicillin-sensitive staphylococcus bacteria, the birth bacteria cytrobacter (C. freundii, C. koseri), enterobacter, campylobacter, small intestine bacilli, P. lanella P. vulgaris), serrations, Providencia rettgeri, Salmonella, Shigella, Yersinia and Pasteurella.

A member of the 5-nitroimidazole group, ternidazole has a bactericidal effect directed at microorganisms capable of reducing the nitro group. Under the influence of the restored form of ternidazole, the synthesis of DNA and proteins of the microorganism is disrupted, the processes of cellular respiration are inhibited. Ternidazole is active against anaerobes (including Gardnerella vaginalis) and Trichomonas vaginalis.

The polyene antifungal drug nystatin has both fungistatic and fungicidal effects in vitro against a wide range of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata. Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to ergosterols of the cell membrane of susceptible species, which leads to a change in its permeability and subsequent loss of potassium, as well as other intracellular components and, as a result, the death of the microorganism.

Prednisone is a synthetic GCS used as an anti-inflammatory agent. Prednisolone inhibits leukocyte infiltration at the site of inflammation, inhibits the effects of mediators of the inflammatory response and suppresses the humoral immune response. The anti-inflammatory effect of GCS is associated with phospholipase A inhibiting2 lipocortin proteins that control the biosynthesis of such powerful inflammatory mediators as prostaglandins and leukotrienes. Prednisolone reduces the severity of the inflammatory reaction, limiting the dilatation of capillaries and the permeability of the vascular wall. Prednisolone is an agonist of corticosteroids receptors: the corticosteroids receptor-ligand complex translocates to the cell nucleus, where it binds to elements of the glucocorticoid response in the region of the promoter of the target genes. A DNA-bound receptor then interacts with major transcription factors, causing an increase or decrease in the expression of specific target genes, including suppression of expression of interleukin 2.

Pharmacokinetic parameters. Not investigated.

Indications

Therapy for inflammation of the vaginal mucosa caused by microorganisms that are sensitive to the drug. this pathology includes vaginitis of bacterial etiology (pyogenic banal microflora); desquamative, caused by the action of opportunistic microorganisms; caused by trichomonas vaginalis; candidal etiology; mixed etiology (yeast-like fungi, anaerobes and trichomonas vaginalis).

Application

Intravaginally for adults 1-2 times a day, 1 vaginal tablet (before use, wash your hands gently and moisten the tablet with water for 2-3 seconds). enter at the most convenient depth in the supine position with bent legs, maintain a horizontal position for about 15 minutes after the procedure.

The course of therapy (during menstruation is not interrupted) is an average of 10 days.The established mycotic etiology of vaginitis requires an increase in the duration of the course to 20 days. Against the background of drug therapy, it is necessary to adhere to the rules of personal hygiene and beware, if possible, of the effects of adverse factors.

Contraindications

Hypersensitivity to the components of the drug.

It should not be combined with acetylsalicylic acid in a specific dosage.

Side effects

  • Hypersensitivity; allergic dermatitis, itching, rashes, urticaria; local reactions (irritation, tingling sensation), erosion, swelling and burning sensation in the vagina, hyperemia, pain, itching in the vulva and vagina.

special instructions

In order to prevent reinfection, the patients sexual partner should be simultaneously treated.

There is a possibility of insignificant absorption of any component of the drug.

Hypersensitivity in the case of topical use of antibiotics can be a confirmation of the unjustified use of them (or other related compounds).

The duration of therapy should be limited to reduce the likelihood of developing resistant strains or superinfection with them.

Do not use in childhood.

In the presence of indications, it is possible to use under medical supervision in pregnant women and during lactation.

The ability to drive vehicles or work with other mechanisms is not affected.

Interactions

It is undesirable to combine with the intake of acetylsalicylic acid in a daily dose of 3 g or more (or 1 g or more per reception).

With caution, they are used with anticonvulsants, inducers of the synthesis of liver metabolism enzymes; isoniazid; rifampicin; drugs that reduce the level of potassium in the blood; digitalis preparations; drugs that can cause arrhythmias like torsades de pointes.

Increased attention is required when combined with cyclosporine, acetylsalicylic acid (daily dose of 3 g or ≥500 mg per dose) and other NSAIDs, antibiotics of the fluoroquinolone group.

Overdose

No information.

Storage conditions

At a temperature of ≤25 ° C in the original packaging out of the reach of children.

Tags: Tergynan