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Pharmacological properties

spiramycin is an antibiotic of the macrolide group that has a bactericidal effect.

The spectrum of antimicrobial activity. The critical concentration, which allows to differentiate sensitive species of microorganisms from species with intermediate sensitivity, is 1 mg / l; and species with intermediate sensitivity from resistant - 4 mg / L. The prevalence of acquired resistance among certain types of microorganisms may vary depending on geographic location and a specific period. Therefore, it is useful to have local information on the prevalence of resistance, especially in the treatment of severe infections. The data provided only allow us to assess the likelihood of sensitivity of a bacterial strain to this antibiotic. The prevalence of bacterial resistance to spiramycin in France is shown in the table.

Category The prevalence of acquired resistance in France (10%),%
Sensitive species
Gram-positive aerobes  
Bacillus cereus  
Corynebacterium diphtheriae  
Enterococci  
Rhodococcus equi  
Methicillin-sensitive strains of Staphylococcus spp.  
Methicillin-resistant strains of Staphylococcus spp. * 50–70
Group B Streptococcus 70–80
Unclassified Streptococcus spp. 30–40
Streptococcus pneumoniae 35–70
Streptococcus pyogenes 16–31
Gram-negative aerobes  
Bordetella pertussis  
Branhamella catarrhalis  
Campylobacter spp.  
Legionella pneumophila  
Moraxella spp.  
Gram-negative anaerobes  
Actinomyces spp.  
Bacteroides spp.  
Eubacterium spp. 30–60%
Mobiluncus spp.  
Peptostreptococcus spp.  
Porphyromonas spp. 30–40%
Prevotella spp.  
Propionibacterium acnes  
Various  
Borrelia burgdorferi  
Chlamydia spp.  
Coxiella burnetii  
Leptospira spp.  
Mycoplasma pneumoniae  
Treponema pallidum  
Moderately sensitive species

(intermediate level of sensitivity in vitro)

Gram-negative aerobes  
Neisseria gonorrhoeae  
Gram-negative anaerobes  
Clostridium perfringens  
Various  
Ureaplasma urealyticum  
Resistant Views
Gram-positive aerobes  
Corynebacterium jeikeium  
Nocardia asteroides  
Gram-negative aerobes  
Acinetobacter spp.  
Enterobacteriaceae  
Haemophilus spp.  
Pseudomonas spp.  
Gram-negative anaerobes  
Fusobacterium spp.  
Various  
Mycoplasma hominis  

* The prevalence of methicillin resistance is characteristic of inpatient departments of hospitals.

Spiramycin activity against Toxoplasma gondii was demonstrated in vitro and in vivo.

Farmak

Tags: Spiramycin