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Pharmacological properties

ornidazole. the mechanism of action of ornidazole is associated with a violation of the structure of DNA in microorganisms sensitive to it. the drug easily penetrates into the microbial cell and, binding to dna, disrupts the replication process. Ornidazole is active against trichomonas vaginalis, entamoeba histolytica, giardia lamblia (giardia intestinalis), as well as some anaerobic bacteria such as bacteroides and clostridium spp., fusobacterium spp., and anaerobic cocci.

Miconazole Miconazole is an antifungal drug intended for topical treatment of vulvovaginal candidiasis (moniliasis), active only against Candidal vulvovaginatis.

Neomycin. Neomycin is an antibiotic that belongs to the group of aminoglycosides. Aminoglycosides have high activity against gram-negative, as well as effective against gram-positive bacteria. Penetrates into the structure of a bacterial cell due to the production of abnormal proteins. These proteins block the formation of proteins necessary for bacterial viability.

Prednisolone is a synthetic corticosteroid used to reduce the severity of inflammation symptoms. Prednisone inhibits the secretion and release of inflammatory mediators and proliferative processes in inflammatory diseases and reduces the likelihood of scarring.

Pharmacokinetics Despite the local use of the drug, systemic absorption is possible, especially with inflammation of the vagina. A systemic action of the components is not expected, but possible minor systemic absorption should be considered.

The concentration of ornidazole in the tissues of the vagina significantly exceeds the concentration achieved with its oral and / in use.

Systemic absorption of miconazole in topical application is limited. It has selective toxicity for yeast fungi of the genus Candida.

Neomycin almost does not penetrate the body through intact skin. It penetrates the structure of a bacterial cell due to the production of abnormal proteins. These proteins block the synthesis of proteins necessary for the survival of bacteria.

Prednisolone reduces the symptoms of inflammation, including hyperemia.

Indications

Treatment of combined gynecological diseases, in particular bacterial vaginosis and vaginitis (caused by candida albicans), mixed infections (caused by trichomonads, anaerobic infection, including gardnerella and yeast-like fungi).

Prevention of gynecological diseases before surgical treatment.

Vaginal sanitation: before childbirth or abortion, before and after the introduction of intrauterine contraceptives, before and after diathermocoagulation of cervical erosion, before intrauterine examinations.

Application

The drug is administered deep into the vagina 1 tablet at night. after administration should be at least 15 minutes do not interrupt treatment during menstruation. continued use of tablets even when all symptoms of the disease have disappeared.

The average duration of treatment with the drug is 8 days. If after an 8-day course of therapy the symptoms do not disappear, then treatment should be repeated.

Order of administration: place the vaginal tablet in the applicator.

Immerse the applicator with the tablet in warm (30–40 ° C) boiled water for several seconds. Carefully insert the applicator with the tablet as deep as possible into the vagina (preferably in the supine position).

Leave the tablet in the vagina, removing it from the applicator, then wash the applicator with warm, soapy water, rinse and dry.

Contraindications

Hypersensitivity to active substances, other imidazole derivatives and other components of the drug.

Systemic and local infectious diseases before the appointment of specific therapy.

Side effects

The drug is well tolerated by all patients.

Spasm and headache, irritation, itching, burning, pain, erosion rarely occur; systemic effects: with topical administration, slight absorption of the components of the drug is possible. When systemic effects of corticosteroids occur, it is possible to slow the healing of wounds and cracks, atrophy of the mucous membrane.

Very rarely - allergic reactions, including rash, itching, urticaria.

In case of development of hypersensitivity reactions or irritation, discontinue use of the drug.

special instructions

The drug should be used with caution under the constant supervision of specialists in patients who simultaneously use systemic corticosteroids in case of osteoporosis, heart failure, heart failure, with existing or history of serious emotional disorders, tuberculosis, diabetes mellitus, glaucoma, myopathy caused by the use of corticosteroids, liver failure , epilepsy, peptic ulcer, hypothyroidism, recent myocardial infarction.

Use with caution in patients with severe pseudoparalytic myasthenia gravis, nonspecific colitis, diverticulitis, and recent intestinal anastomoses.

Despite the local use of the drug, systemic absorption is possible, especially with inflammation of the vagina.

Adverse reactions can be minimized by using the drug for the shortest period of treatment and under constant monitoring.

The drug contains lactose, therefore, patients with galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use Neotrizol.

Use during pregnancy and lactation. When deciding on the use of the drug in pregnant women, the benefit / risk ratio should be weighed. Since corticosteroids in small amounts can pass into breast milk, possible signs of inhibition of adrenal function should be monitored.

Children. The drug is not used in children.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug does not affect the reaction rate when driving vehicles or working with other mechanisms.

Interactions

No clinically significant interactions with other drugs have been identified. however, possible systemic absorption of the drug should be taken into account, especially in the presence of inflammation.

Overdose

In connection with the local action of the drug, an overdose was not noted, an increase in the manifestations of adverse reactions is possible. symptomatic treatment.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.

Tags: Neotrizol