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Pharmacological properties

Combined vaginal tablets containing antimicrobial agents and corticosteroids.

The mechanism of action of ornidazole is associated with a violation of the DNA structure of microorganisms sensitive to it. Ornidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia (Giardia intestinalis), as well as some anaerobic bacteria such as Bacteroides and Clostridium spp., Fusobacterium spp. and anaerobic cocci.

Neomycin is an antibiotic of the aminoglycoside group. Aminoglycosides are highly active against gram-negative and gram-positive bacteria. Neomycin disrupts the structure of a bacterial cell due to the synthesis of abnormal proteins.

Nystatin is a polyene antifungal antibiotic. It acts on the membrane of fungi, binding to one of its components - ergosterol, causing structural disruption and death of the fungal cell. The drug has selective toxicity to fungi, since human cells or bacteria instead of ergosterol contain cholesterol.

Prednisolone is a synthetic GCS and has a pronounced anti-inflammatory effect. Prednisolone inhibits the secretion and release of inflammatory mediators, proliferative processes in inflammatory diseases and reduces the likelihood of scarring.

With intravaginal administration, the concentration of ornidazole in the tissues of the vagina is significantly higher than that for its oral and intravenous administration, and the systemic effect is not observed.

When applied topically, neomycin and nystatin are highly active, the latter against fungi of the genus Candida.

Prednisone effectively reduces the activity of the inflammatory process.

Indications

Bacterial vaginosis and vaginitis, Trichomonas vaginitis, fungal vaginitis caused by candida albicans; vaginitis caused by a mixed infection (trichomonads, anaerobic microflora, gardnerella and yeast-like fungi); with a preventive purpose before surgery for gynecological diseases, for vaginal sanitation before childbirth or abortion, before and after the introduction of intrauterine contraceptives, diathermocoagulation of cervical erosion, before an intrauterine examination.

Application

Enter deep into the vagina, 1 tablet at night. after administration, it is recommended to be in a supine position for at least 15 minutes. the average duration of treatment is 10 days without a break during menstruation.

A vaginal tablet is placed in the applicator, immersed in warm (30–40 ° C) boiled water or isotonic sodium chloride solution for 15–30 s, after which it is carefully injected as deep as possible into the vagina (preferably in the supine position) and leave the pill in the vagina by removing it from the applicator.

Contraindications

Hypersensitivity to any of the components of the drug.

Side effects

Rarely - local irritation, hypersensitivity reactions. with the development of side effects, treatment is stopped.

special instructions

Due to the low systemic absorption of the drug, the concentration of its components in the systemic circulation is minimal, which allows it to be used during pregnancy and lactation.

Interactions

Clinically significant interactions are not described. preparations for intravaginal use can have a negative effect on latex contraceptives and contraceptives for topical use, therefore, other methods of contraception should be used during treatment with meratin combi.

Overdose

Due to the local effect of the drug, an overdose is unlikely.

Storage conditions

In a dry, dark place at a temperature of 15-25 ° C.